Cantoblanco Workshops on Biology
INITIATION OF ANTIGEN RECEPTOR SIGNALING
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Workshop
organized by Balbino Alarc—n, Mark M. Davis, and Arthur Weiss
October, 20-22, 2008, Campus of the Universidad Aut—noma de Madrid,
Spain
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Although it has been
already 24 years since the T cell antigen receptor (TCR) was molecularly
characterized, and almost 20 years since the subunit composition of the
equivalent receptor in B cells (BCR) was deciphered, there are still
important unanswered questions about the intramolecular mechanisms that allow
these receptors to distinguish between self and non-self, especially with
regard to the activation of intracellular signaling pathways. One of the
major obstacles to understand how TCR and BCR initiate the activation process
is that the structures of the complete TCR and BCR complexes are unknown.
This makes it very difficult to gain knowledge on the changes produced among
the subunits that compose the TCR and BCR after triggering of the receptors
by ligands of different quality. Overcoming this hurdle asks for a
multi-disciplinary approach to the study of the earliest signaling
mechanisms. Special attention will be paid on structural aspects,
with the participation of crystallographers and electron microscopists, on
the organization and function of the immune synapse, and on proteomics
of the TCR signalosome. One of the aims of the Workshop will be to
contrast sometimes conflicting hypothesis about how the signaling process is
initiated. This should favor an open discussion about these
mechanisms, with a focus on the most recent data that will be presented in
the Workshop. There will be researchers in the study of the TCR and the BCR
to favor a comparison between both receptors. Nevertheless,
the last goal of the Workshop will be to provide a
format for the exchange of ideas and information, to discuss the latest
research findings and methodological advances, and to foster interactions. |
Speakers include:
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Balbino
Alarc—n CBMSO, Madrid (Spain) Cosima T. Baldari. University of Siena, Siena (Italy) Centro de Investigación del Cancer, Salamanca (Spain) Arup
K. Chakraborty MIT, Cambridge, MA (USA) Mark
M. Davis Stanford Univ. School of Medicine, Stanford,
CA (USA) Michael
Dustin NYU School of Medicine, New York, NY (USA) K.
Christopher Garcia Stanford Univ. School of Medicine, Stanford,
CA (USA) Nicholas
R. Gascoigne The Scripps Research Institute, La Jolla, CA
(USA) John
W. Kappler Howard Hughes Medical Institute, Denver, CO
(USA) Gary
Koretzky Abramson Family Cancer Res. Inst.,
Philadelphia, PA (USA) Tomohiro
Kurosaki RIKEN Research Center, Yokohama (Japan) Bernard
Malissen Centre dÕImmunologie de Marseille Luminy ,
Marseille (France) Mario
Mellado CNB, Madrid (Spain) |
Ed
Palmer University Hospital Susan
K. Pierce NIAID, Rockville, MD (USA) Harvard Medical School, Boston, MA (USA) Michael
Reth Max-Plank-Inst. of Immunology, Freiburg
(Germany) Jamie Rossjohn MONASH
Univeristy, Victoria, VIC (Australia) Takashi Saito RIKEN Research Center, Yokohama (Japan) Lawrence E. Samelson National
Cancer Institute, Bethesda, MD (USA) Francisco S‡nchez-Madrid Hospital de la Princesa-UAM,
Madrid (Spain) Wofgang Schamel Max-Plank-Inst. of Immunology, Freiburg
(Germany) JosŽ M. Valpuesta CNB, Madrid (Spain) Anton Van der Merwe University of
Oxford Arthur Weiss University of
California, San Francisco, CA (USA) Rose Zamoyska National
Inst. for Medical Res., London (UK) |
Participants: No registration fee is required
but prospective participants must apply by registering at http://www2.cbm.uam.es/antigen/registrationform.htm.
To
be admitted as participants, applicants need to send a short biographical
sketch with the publication list from your CV. Preference will be given to
those who provide an abstract for a poster/short talk (see below).
Short Talks & Posters: Abstracts submitted for
posters will be judged for thematic content to determine if they are appropriate
for short talks. Please submit a one page abstract by E-mail to registration-antigen@cbm.uam.es
along with a short CV including a publication list.
The final deadline is: August 11, 2008. You will
be notified if you have been selected as participant as well as for a short
talk.
For directions please go to: http://www.uam.es/presentacion/campus/defaulting.html
Sponsored by
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