bioweb: molecular modelling group / grupo de modelado molecular

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Eduardo López-Viñas

Dr. Eduardo López-Viñas.
(Madrid -Spain-. 1973)
Investigador Doctor. Biomol-Informatics / CBMSO.

Centro de Biología Molecular "Severo Ochoa".
C/ Nicolás Cabrera, 1.
Campus UAM. Cantoblanco, 28049 Madrid. Spain.
Tel: (+34) 91-196-4662   Fax: (+34) 91-196-4420
e-mail: edulovi@cbm.uam.es
URL: http://www.cbm.uam.es/bioweb

Academic degrees / Títulos académicos
    1999. B.Sc. Biological Sciences / Diplomado en Biología (Universidad de Alcalá de Henares, Madrid).
    2001. M. Sc. Biological Sciences / Licenciado en Biología (Universidad de Alcalá de Henares, Madrid).
    2004. Advanced Studies Degree in Biochemistry and Molecular Biology /
               Diploma de Estudios Avanzados en Bioquímica y Biología Molecular. (Universidad Autónoma de Madrid).
    2008. Ph.D. Biochemistry and Molecular Biology / Doctor en Bioquímica y Biología Molecular. (Universidad Autónoma de Madrid).
Career / Trayectoria profesional.
    1997. Under graduate student / Estudiante de licenciatura. (Universidad de Alcalá de Henares, Madrid).
    2001. Ph.D. student / estudiante de doctorado. Dpt. Bioquímica y Biología Molecular. U. Autónoma Madrid..
    2006. Specialized Tech. / Titulado Superior. Centro de Biología Molecular "Severo Ochoa". CSIC.
    2008. Postdoctoral Scientist / Investigador Posdoctoral CIBER/CSIC. Centro de Biología Molecular "Severo Ochoa". CSIC.
    2009. Torres-Quevedo Contract - Ministry of Science and Innovation / Contrato Torres-Quevedo del Ministerio de Ciencia e Innovación.
    2009-. Head of Drug Discovery. Molecular Modelling Group / Biomol-Informatics. Contract for Research and Development on Bioinformatics between Biomol-Informatics SL and Fundación "Severo Ochoa"
Participation in research projects / Participación en proyectos de investigación
  • "Bio-PARTNeR: Protein interaction network". Fundación Ramón Areces. 2002 - 2005. (Principal Inv: Paulino Gómez-Puertas).
  • "GenomeSpace: Sequence to structure". Intramural CAB. 2003 - 2004. (Principal Inv: Paulino Gómez-Puertas).
  • "Molecular basis of the anti-obesity properties of C75 compound". Fundacion Puleva. Research Prize 2004. (Principal Inv: Fausto G. Hegardt, Univ. Barcelona).
  • "Bioinformatics: Protein-protein and protein-ligand interactions. Modelling human CPTI function". Plan Nacional I+D+I. 2004 - 2007. Ref: SAF2004-06843. (Coord: Fausto G. Hegardt, Univ. Barcelona; Principal Inv: Paulino Gómez-Puertas).
  • "Bioinformatics: Structure and function of human CPTI". F.I.S. CIBER 2006: Fisiopatología de la Obesidad y Nutrición. Ref: CB06/03/0026. (Inv. Principal: Fausto G. Hegardt, Univ. Barcelona).
  • "BIOSINCEL. Synthetic biology of cellular division: reconstruction of the bacterial division proto-ring". CSIC: Proyectos Intramurales de Frontera 2006. Ref: 200620F0022. (Coord: Miguel Vicente, CNB-CSIC; Principal Inv: Paulino Gómez-Puertas).
  • "COMBACT-CM. New targets to combat pathogenic bacteria". Comunidad de Madrid, I+D Biociencias 2006. Ref: S-BIO-0260-2006. (Coord: Miguel Vicente, CNB-CSIC; Principal Inv: Paulino Gómez-Puertas).
  • "Molecular bases of action of carnitine palmitoyltransferases as regulators of fat oxidation and their role on insulin resistance, type II diabetes and the hypothalamic appetite regulation". Plan Nacional I+D+I 2007. Eje-C Consolider. Ref: SAF2007-61926. (Coord. Consolider: Fausto G. Hegardt, Univ. Barcelona).
  • 2009-2012. "DIVINOCELL. Exploiting Gram-negative cell division targets in the test tube to obtain antimicrobial compounds". FP7 collaborative project FP7-HEALTH-F3-2009-223431. (Biomol-Informatics).
  • 2011-2014. "DIGEN-1K: Experimental development of a Genetic Diagnostics Method using Next Generation Sequencing". Plan Nacional I+D+I Ref.: INNPACTO IPT-2011-0964-900000. (Principal Inv.: Paulino Gómez-Puertas).
Participation in R&D contracts / Participación en contratos de I+D. Publications / Publicaciones (PubMed)
(A: article/artículo; R: review/revisión; C: book chapter/capítulo de libro; O: other/otros)

 2012:
 
24(A).-
 Martín-García, F., Mendieta-Moreno, J.I., López-Viñas, E., *Gómez-Puertas, P. & *Mendieta, J. (* Co-last authors) (2012). The Role of Gln(61) in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study. Biophysical Journal 102, 152-157.  [PubMed]  [PDF]  [Supp. Inf. PDF]  [Supp. video. AVI]  [Supp. video. AVI -HD-]

 2011:
 
23(A).-
 Hurtado, C., Bustos, M.J., Granja, A.G., de León, P., Sabina, P., López-Vinas, E., Gómez-Puertas, P., Revilla, Y. & Carrascosa, A.L. (2011). The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens. Archives of Virology 156, 219-234.  [PubMed]  [PDF]

 2010:
 
22(A).-
 Pié, J., Gil-Rodríguez, M.C., Ciero, M., López-Viñas, E., Ribate, M.P., Arnedo, M., Deardorff, M.A., Puisac, B., Legarreta, J., de Karam, J.C., Rubio, E., Bueno, I., Baldellou, A., Calvo, M.T., Casals, N., Olivares, J.L., Losada, A., Hegardt, F.G., Krantz, I.D., Gómez-Puertas, P. & Ramos F.J. (2010). Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome. American Journal of Medical Genetics. Part A. 152A, 924-929.  [PubMed]  [PDF]  [Suppl.Material. PDF]

 2009:
 
21(A).-
 Barbas, A., Matos, R.G., Amblar, M., López-Viñas, E., Gómez-Puertas, P. & Arraiano, C.M. (2009). Determination of key residues for catalysis and RNA-cleavage specificity: one mutation turns RNase II into a "super"-enzyme. Journal of Biological Chemistry 284, 20486-20498.  [PubMed]  [PDF]
20(A).-
 Mendieta, J., Rico, A.I., López-Viñas, E., Vicente, M., Mingorance, J. & Gómez-Puertas, P. (2009). Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin. Journal of Molecular Biology 390, 17-25.  [PubMed]  [PDF]
19(A).-
 Menao, S., López-Viñas, E., Mir, C., Puisac, B., Gratacós, E., Arnedo, M., Carrasco, P., Moreno, S., Ramos, M., Gil, M.C., Pié, A., Ribes, A., Pérez-Cerda, C., Ugarte, M., Clayton, P.T., Korman, S.H., Serra, D., Asins, G., Ramos, F.J., Gómez-Puertas, P., Hegardt, F.G., Casals, N. & Pié, J. (2009). Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria. Human Mutation 30, E520-9.  [PubMed]  [PDF]
18(A).-
 Mera, P., Bentebibel, A., López-Viñas, E., Cordente, A.G., Gurunathan, C., Sebastián, D., Ariza, X., Gómez-Puertas, P., Asins, G., Serra, D., García, J. & Hegardt, F.G. (2009). C75 is Converted to C75-CoA in the Hypothalamus, where it Inhibits Carnitine Palmitoyltransferase 1 and Decreases Food Intake and Body Weight. Biochemical Pharmacology 77, 1084-1095.  [PubMed]  [PDF]

 2008:
 
17(A).-
 Cuellar, J., Martin-Benito, J., Scheres, S.H.W., Sousa, R., Moro, F., Lopez-Viñas, E., Gomez-Puertas, P., Muga, A., Carrascosa, J.L. & Valpuesta, J.M. (2008). The structure of a CCT:Hsc70NBD complex suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nature Structural & Molecular Biology 15, 858-864.  [PubMed]  [PDF]  [Suppl.Info-PDF]
16(A).-
 Barbas, A., Matos, R.G., Amblar, M., López-Viñas, E., Gómez-Puertas, P. & Arraiano, C.M. (2008). New insights into the mechanism of RNA degradation by ribonuclease II: identification of the residue responsible for setting the RNase II end-product. Journal of Biological Chemistry 283, 13070-13076.  [PubMed]  [PDF]
15(A).-
 Llorente, M.T., Taylor, I.A., López-Viñas, E., Gómez-Puertas, P., Calder, L.J., García-Barreno, B. & Melero, J.A. (2008). Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase co-factors. PROTEINS: Structure, Function and Bioinformatics 72, 946-958.  [PubMed]  [PDF]
14(A).-
 López-Viñas, E.*, Atrian, S.*, Gomez-Puertas, P., Chabás, A., Vilageliu, L. & Grinberg, D. (2008). An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions. Relevance for Gaucher disease. PROTEINS: Structure, Function and Bioinformatics 70, 882-891.  [PubMed]  [PDF]
(* Co-first authors)

2007:
 
13(A).-
 Blas-Galindo, E., Cava, F., López-Viñas, E., Mendieta, J. & Berenguer, J. (2007). Use of a dominant rpsL allele conferring streptomycin dependence for positive and negative selection in Thermus thermophilus. Applied and Environmental Microbiology 73, 5138-5145.  [PubMed]  [PDF]  [Suppl. Mat.]
12(R).-
 Pié J., López-Viñas, E., Puisac, B., Menao, S., Pié A., Casale, C., Ramos, F., Hegardt, F.G., Gómez-Puertas, P. & Casals, N. (2007). Molecular genetics of HMG-CoA lyase deficiency. Molecular Genetics and Metabolism 92, 198-209.  [PubMed]  [PDF] (cover paper / artículo de portada).
11(A).-
 López-Viñas, E., Bentebibel, A., Gurunathan, C., Morillas, M., De Arriaga, D., Serra, D., Asins, G., Hegardt, F. & Gómez-Puertas, P. (2007). Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. Journal of Biological Chemistry 282, 18212-18224.  [PubMed]  [PDF]
10(A).-
 Carrasco, P., Menao, S., Lopez-Viñas, E., Santpere, G., Clotet, J., Sierra, A.Y., Gratacos, E., Puisac, B., Gomez-Puertas, P., Hegardt, F.G., Pie, J. & Casals, N. (2007). C-Terminal End and Aminoacid Lys48 in HMG-Coa Lyase Are Involved in Substrate Binding and Enzyme Activity. Molecular Genetics and Metabolism 91, 120-127.  [PubMed]  [PDF] (cover paper / artículo de portada).

  2006:
 
9(A).-
 Cordente, A.G., Lopez-Viñas, E., Vazquez, M.I., Gomez-Puertas, P., Asins, G., Serra, D. & Hegardt, F.G. (2006). Mutagenesis of specific amino acids converts carnitine  acetyltransferase into carnitine palmitoyltransferase. Biochemistry45,6133-6141.  [PubMed]  [PDF]
8(A).-
 Bentebibel, A., Sebastian, D., Herrero, L., Lopez-Viñas, E., Serra, D., Asins, G., Gomez-Puertas, P. & Hegardt, F.G. (2006).  Novel effect of C75 on Carnitine Palmitoyltransferase I activity and palmitate oxidation. Biochemistry 45, 4339-4350.  [PubMed]  [PDF]
7(A).-
 Mir, C., Lopez-Viñas, E., Aledo, R., Puisac, B., Rizzo, C., Dionisi-Vici, C., Deodato, F., Pie, J., Gomez-Puertas, P., Hegardt, F.G. & Casals, N. (2006).  A single residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase -Review. Journal of Inherited Metabolic Disease 29, 64-70.  [PubMed]  [PDF]
6(R).-
 Ortiz, A.R., Gomez-Puertas, P., Leo-Macias, A., Lopez-Romero, P., Lopez-Viñas, E., Morreale, A., Murcia, M., & Wang, K. (2006) Computational approaches to model ligand selectivity in drug design. Current Topics in Medicinal Chemistry 6, 41-55.  [PubMed]  [PDF]

  2005:
 
5(O).-
 Lopez-Viñas, E. & Gomez-Puertas, P. (2005) -Scientific divulgation-. Bioinformatica, la informacion al servicio de la ciencia (Bioinformatics, information in the service of science). Journal of the Official College of Physicists of Spain: Fisica y Sociedad 16, 46-50. [PDF]
4(A).-
 Puisac, B., Lopez-Viñas, E., Moreno, S., Mir, C., Perez-Cerda, C., Menao, S., Lluch, D., Pie, A., Gomez-Puertas, P., Casals, N., Ugarte, M., Hegardt, F.G. & Pie, J. (2005). Skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL. Biophysical Chemistry 115, 241-245.  [PubMed]  [PDF]

  2004:
 
3(A).-
 Cordente, A.G., Lopez-Viñas, E., Vazquez, M.I., Swiegers, J.H., Pretorius, I.S., Gomez-Puertas, P., Hegardt, F.G., Asins, G. & Serra, D. (2004). Redesign of carnitine acetyltransferase specificity by protein engineering. Modification of methionine564 broadens the specificity to longer acyl-CoAs as substrates. Journal of Biological Chemistry 279, 33899-33908.  [PubMed]  [PDF]
2(C).-
 Lopez-Viñas, E. & Gomez-Puertas, P. (2004). Sequence and structural alignments of eukaryotic and procaryotic cytoskeletal proteins. Chapter for "Molecules in time and space: Bacterial shape, division and phylogeny." M. Vicente, J. Tamames, A. Valencia & J. Mingorance (Eds.) Kluwer Academic/Plenum Publishers. 
1(A).-
 Morillas, M., Lopez-Viñas, E., Valencia, A., Serra, D., Gomez-Puertas, P., Hegardt, F.G. & Asins, G. (2004). Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochemical Journal 379, 777-784.  [PubMed]  [PDF]

Meetings / Congresos

  • López-Viñas, E., Bastolla, U. & Gómez-Puertas, P (2003). ProtFinder: An algorithm for Protein Structure Prediction. XXVI c. de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). La Coruña.
  • López-Viñas, E., Bastolla, U. & Gómez-Puertas, P (2003). ProtFinder: An algorithm for Protein Structure Prediction. IV Jornadas de Bioinformática, La Coruña.
  • López-Viñas, E. & Gómez-Puertas, P (2003). Obtención de información evolutiva a partir del análisis de secuencias. I Feria Internacional de Biotecnología, Mundo BIOTECH.-2003. Madrid.
  • López-Viñas, E. & Gómez-Puertas, P. (2003). FtsA & FtsZ families of proteins. Bioinformatic analysis of sequences and structures.Workshop on "Manufacturing Bacteria: Design, Production and Assembly of Cell Division Components" Fundación Juan March. Madrid.
  • Morillas, M., López-Viñas, E., Valencia, A., Serra, D., Gómez-Puertas, P., Hegardt, F. G. & Asins, G. (2003). Modelo estructural de la Carnitina Palmitoiltransferasa I basado en el cristal de la Carnitina Acetiltransferasa. XXVI C. de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). La Coruña.
  • López-Viñas, E., Cordente, G., Morillas, M., Hegardt, F.G & Gómez-Puertas, P. (2004). Bioinformatic analysis of functional characteristics of enzymatic active centres using both sequence and structure information. An application to the carnitine/choline acyltransferases protein family. V Jornadas de Bioinformática. Barcelona.
  • Moreno, S., Lopez-Viñas, E., Puisac, B., Casals, N., Menao, S., Triñanes, E., Alcalde, I., Pie, A, Gomez-Puertas, P., Hegardt, F.G. & Pie, J. (2004). Location of the missense mutation E37K at the structural (beta-alpha)8 TIM barrel model of HMG-CoA lyase. BIFI 2004. Biology after the Genome: a Physical View. Zaragoza.
  • Puisac, B., Lopez-Viñas, E., Moreno, S., Casals, N., Menao, S., Fernandez, M., Ramos, M., Gomez-Puertas, P., Hegardt, F.G. & Pie, J. (2004). The skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produce the loss of beta sheets 1 and 2 at the proposed (beta-alpha)8 TIM barrel model of HL. BIFI 2004. Biology after the Genome: a Physical View. Zaragoza.
  • López-Viñas, E. & Gómez-Puertas, P (2004). Bioinformática: Integración de datos de secuencia y estructura para el estudio de la función de las proteínas. II Feria Internacional de Biotecnología, Mundo BIOTECH.-2004. Madrid. (COMUNICACIÓN ORAL)
  • López-Viñas, E. & Gómez-Puertas, P. (2004). Use of "in silico" docking techniques to predict novel protein-ligand and protein-protein interactions. Micro-MATRIX workshop on strategies to address antimicrobial resistance through the exploitation of microbial genomics. Castillo de Magalia, Las Navas, Ávila. (COMUNICACIÓN ORAL).
  • Deplanche, M., Meyer, G., López-Viñas, E., Gómez-Puertas, P., Moulignie, M., Counor, D., Eleouët, J.-F. & Baranowski, E. (2005) Rôle intermédiaire d'une lignée cellulaire de hamster dans l'adaptation du virus respiratoire syncytial bovin aux cellules épithéliales humaines. MicrobioToul 2005. Toulouse (France).
  • Mendieta, J., López-Viñas, E. & Gómez-Puertas, P. (2007). Molecular Dynamics Simulations of Bacterial FtsZ Polymerization. 32nd FEBS Congress: Molecular Machines. Wien (Austria).
  • López-Viñas, E., Mendieta, J. & Gómez-Puertas, P. (2007). Structural and Functional Bioinformatic Model for Inhibition of Human Carnitine-palmitoyltransferase 1. 32nd FEBS Congress: Molecular Machines. Wien (Austria).
  • López-Viñas, E., Mendieta, J., Serra, D., Asins, G., Hegardt, F.G. & P. Gómez-Puertas. (2007) Modelo Bioinformático Estructural y Funcional de la Inhibición de la Carnitina-palmitoiltransferasa 1 Humana. 1st International Symposium CIBERobn. Santiago de Compostela. (COMUNICACIÓN ORAL)
  • Hurtado, C., Bustos, M.J., Granja, A.G., López-Viñas, E., Gómez-Puertas, P., Revilla, Y. & Carrascosa, A.L. (2007) La lectina del VPPA presenta una estructura similar a la de los receptores inhibitorios de células NK y modula la expresión de antígenos de histocompatibilidad. IX Congreso Nacional de Virología. Zaragoza. (COMUNICACIÓN ORAL).
  • Mendieta, J., López-Viñas, E. & Gómez-Puertas, P. (2008). Molecular Dynamics Simulations of Bacterial FtsZ Polymerization. VIII Jornadas de Bioinformática. Valencia.
  • López-Viñas, E., Mendieta, J. & Gómez-Puertas, P. (2008). Structural and Functional Bioinformatic Model for Inhibition of Human Carnitine-palmitoyltransferase 1. VIII Jornadas de Bioinformática. Valencia. (COMUNICACIÓN ORAL)
  • Martín-García, F., Rico, AI., López-Viñas, E., Vicente, M., Mingorance, J., Gómez-Puertas, P. & Mendieta, J. (2009). Molecular Dynamics Simulations of Bacterial FtsZ Polymerization. Frontiers of Prokaryotic Cell Biology. EMBO workshop. Oxford (UK)
  • 8th European Biophysics Congres. 2011 Budapest (Hungary).
  • XIth Spanish Simposium on Bioinformatics (JBI2012). 2012. Barcelona (Spain).
TEACHING / DOCENCIA

Undergraduate courses / Asignaturas de licenciatura: Organization of doctorate and specialization courses / Organización de cursos de doctorado y especialización: Collaboration in specialization courses / Colaboración en cursos de especialización:
BIOWEB: MOLECULAR MODELLING GROUP
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM).
http://www.cbm.uam.es/bioweb 		C/ Nicolás Cabrera, 1. Campus UAM, Cantoblanco.
28049 Madrid. Spain
Tel: (+34) 91 196 4662 / 4663   Fax: (+34) 91 196 4420