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Dr. Jan Jacob Wesselink.
(Nederland -Países Bajos-. 1972)
Investigador Biomol-Informatics / CBMSO.
Centro de Biología Molecular "Severo Ochoa".
C/ Nicolás Cabrera, 1.
Campus UAM. Cantoblanco, 28049 Madrid. Spain.
Tel: (+34) 91-196-4662 Fax: (+34) 91-196-4420
e-mail: jjwesselink@cbm.uam.es
URL: http://www.cbm.uam.es/bioweb
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Education
1990-1995. BSc in Biotechnology, University of Arnhem and Nijmegen, Nijmegen, the Netherlands.
2000-2004. PhD in Bioinformatics University of East Anglia, Norwich, United Kingdom.
Experience.
- 1996-1997. Research Assistant, ATO-DLO Research Institute, Wageningen, the Netherlands.
Biochemical/chemical modification of wheat flour and starch for their application in paper coatings.
- 1997-2000. Research Assistant, Janssen Research Foundation, Beerse, Belgium.
Biochemical characterization of human Akt-3 and the study of integrin signalling.
- 2000–2003. Research Associate, School of Computing Sciences, University of East Anglia, Norwich,
United Kingdom. Developed of a framework for a molecular method for the identification of yeast species as part
of the “Data Mining for Emerging Microbial Threats" (http://www2.cmp.uea.ac.uk/~jjw/project)
project.
- 2003-2006. Post-doctoral fellow, Genome Bioinformatics Laboratory, IMIM, Barcelona, Spain.
Study of (conservation of) alternative splicing and alternative transcripts as part of the “ENCODE"
and “ASD" (http://www.ebi.ac.uk/asd) projects.
- 2006-2009. Post-doctoral fellow, Computational and Structural Biology Group, Spanish National
Cancer Research Centre (CNIO), Madrid, Spain. Study of the impact of alternative splicing on the resulting protein product as part
of our involvement in the “ENCODE" (http://www.genome.gov/encode) and “BioSapiens"
(http://www.biosapiens.info) projects.
Computer skills
- Operating systems: Advanced user of Linux, Mac OSX and Windows.
- Office: Advanced user of Microsoft Office.
- Programming: Considerable experience with C++, Java, Perl, Awk and Bash.
- Internet: Content Management Systems such as Joomla and Mambo.
- Graphics: Photoshop, Illustrator, Gimp and Inkscape.
Grants.
- 2005. Juan de la Cierva Grant. Spanish Ministry of Science and Innovation (MICINN).
Teaching.
- 1995. Teaching assistant University of Arnhem and Nijmegen, Nijmegen, the Netherlands.
Several practical courses.
- From 2005. Taught various post-graduate courses on Eukaryotic Gene Prediction:
- Instituto Gulbenkian de Ciência, Oeiras, Portugal.
- 3rd European School of Bioinformatics, Madrid.
- Universidad Autónoma de Madrid, Madrid.
- Universidad Complutense de Madrid, Madrid.
Publications (PubMed)
- Romanelli, V., Belinchón, A., Benito-Sanz, S., Martínez-Glez, V., Gracia-Bouthelier, R., Heath, K.E., Campos-Barros, A.,
García-Miñaur, S., Fernández, L., López-Siguero, J.P., Guillén, E., Gómez-Puertas, P., Wesselink, J.J.,
Mercado, G., Esteban-Marfil, V., Palomo, R., Mena, R., del Campo, M. & Lapunzina, P. (2010). CDKN1C (p57Kip2) Analysis in
Beckwith-Wiedemann syndrome (BWS) Patients: Genotype-phenotype Correlations, Novel Mutations, and Polymorphisms.
American Journal of Medical Genetics (in press).
- M.L. Tress, R. Casadio, A. Giorgetti, P.F. Hallin, A.S. Juncker, E. Kulberkyte, P.
Martelli, D. Raimondo, G.A. Reeves, J.M. Thornton, A. Tramontano, K. Wang, J.J.
Wesselink and A. Valencia. Alternative Splicing in the ENCODE Protein Complement.
In D. Frishman and A. Valencia (eds), Modern Genome Annotation, The
BioSapiens Network, pp. 453–84. Springer, Vienna, New York, 2008.
- M.L. Tress, J.J. Wesselink, A. Frankish, G. López, N. Goldman, A. Löytynoja, T.
Massingham, F. Pardi, S. Whelan, J. Harrow J, A. Valencia. Determination and
validation of principal gene products. Bioinformatics. (24):11–7, 2008.
[PubMed]
- M.L. Tress, P.L. Martelli, A. Frankish, G.A. Reeves, J.J. Wesselink, et al. The implications
of alternative splicing in the ENCODE protein complement. Proc Natl Acad
Sci U S A. (104) 5495–500, 2007.
[PubMed]
- The ENCODE Project Consortium (including J.J.Wesselink). The ENCODE (ENCyclopedia
Of DNA Elements) Project. Science, 306(5696):636–40, 2004.
[PubMed]
- B. de la Iglesia, J.J. Wesselink, V.J. Rayward-Smith, J.L. Dicks, I.N. Roberts,
V. Roberts, T. Boekhout. Developing Classification Techniques from Biological
Databases using Simulated Annealing. In Metaheuristics: Computer Decision-
Making, pp. 347–68, 2003.
- A.P. Reynolds, B. de la Iglesia, J.J. Wesselink, V. Robert, T. Boekhout, J.L. Dicks,
I.N. Roberts, V.J. Rayward-Smith. Algorithms for identification key generation and
optimisation. In Evo-Bio Workshops, 2003.
- J.J. Wesselink, B. de la Iglesia, S. James, J.L. Dicks, I.N. Roberts, V.J. Rayward-
Smith. Determining a unique defining DNA sequence for yeast species using hashing techniques.
Bioinformatics, 18(7):1004–10, 2002.
[PubMed]
- B. De la Iglesia, V.J. Rayward-Smith, J.J. Wesselink. Classification/Identification on
Biological Databases. In J.P. de Souza (ed.), Proceedings MIC2001, 4th International
Metaheuristics Conference, Porto, Portugal.
- B.P. Lomans, P. Leijdekkers, J.J. Wesselink, P. Bakkes, A. Pol, C. van der Drift, H.J.
Op den Camp. Obligate sulphide-dependent degradation of methoxylated aromatic
compounds and formation of methanethiol and dimethylsulfide by a freshwater sediment
isolate, Parasporobacterium paucivorans gen. nov., sp. nov. Applied and
Environmental Microbiology, 67(9):4017–23.
[PubMed]
- S. Masure, B. Haefner, J.J. Wesselink, E. Hoefnagel, E. Mortier, P. Verhasselt, A.
Tuytelaars, R. Gordon, A. Richardson. Molecular cloning, expression and characterisation
of the human serine/threonine kinase Akt-3. European Journal of Biochemistry
(1999), 265(1):353–60, 2001.
[PubMed]
Invited Seminars
- "Genomforschung, was ist das?" German speaking Evangelical Church of Madrid, 2008 (in German).
- "Determination of a unique defining DNA sequence for yeast species using hashing techniques".
John Innes Centre, Norwich, United Kingdom, 2002.
- "What can bioinformatics do for microbiology in the future?" Unilever Research Conference,
Unilever Research, Bedford, United Kingdom, 2000.
Posters
- J.J. Wesselink, J.M. Rodriguez, M.L. Tress, R. Guigó and A. Valencia. A Method for
the Determination of Conservation of Exonic Structure. ECCB, Cagliari, Italy, 2008.
- M.L. Tress, et al.(including J.J. Wesselink). The implications of alternative splicing
in the ENCODE protein complement. ISMB/ECCB, Vienna, Austria, 2007.
- J.J. Wesselink and R. Guigó. Cross-Species Alignment of Alternative Transcripts
of SR Proteins. European Conference on Computational Biology, Madrid, Spain,
2005.
- J.J. Wesselink, A. Reynolds, B. de la Iglesia, J.L. Dicks, I.N. Roberts and V.J.
Rayward-Smith. Data Mining for Emerging Microbial Threats. International Symposium
on Bioinformatics and Computational Biology (III Jornadas de Bioinformática),
Salamanca, Spain, 2002.
- S.A. James, C.J. Bond, M. Stratford, J.J. Wesselink, I.N. Roberts. Molecular typing
of yeasts. British Yeast Group Meeting, Manchester, UK, 2001.
Courses
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BIOWEB: MOLECULAR MODELLING GROUP
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM).
http://www.cbm.uam.es/bioweb
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C/ Nicolás Cabrera, 1. Campus UAM, Cantoblanco.
28049 Madrid. Spain
Tel: (+34) 91 196 4662 / 4663 Fax: (+34) 91 196 4420
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