Cabecera 2019 CBMSO CSIC UAM

Sunday, 25th August 2019

2015.4.24.jbahler

 

Prof. Jürg Bähler

University College London

United Kingdom

 

 

 

 

 

2015 04 24 jurg bahler minEl genoma está regulado en múltiples niveles, y las células necesitan integrar las señales externas e internas y coordinar los diferentes niveles de regulación para ejercer adecuadamente las funciones biológicas. El flujo de información a partir de un determinado genoma (genotipo) y el medio ambiente para producir el fenotipo resultante, está mediado por el “transcriptoma”, con la contribución general, y aún desconocida, de numerosos ARN no codificantes.

La edad es el principal factor de riesgo para numerosas enfermedades y los aspectos fundamentales del envejecimiento son una parte esencial del problema: las mutaciones de un solo gen o la restricción dietética pueden prolongar la vida de forma saludable. Interesantemente, las vías de señalización de nutrientes que afectan a la longevidad están conservadas desde las levaduras a los mamíferos.

El laboratorio del Dr Bähler estudia la regulación del genoma durante la quiescencia celular, el envejecimiento y la respuesta al estrés, utilizando la levadura de fisión como sistema modelo. Para ello se aplican distintos enfoques genéticos, computacionales y genómicos que permiten una comprensión a nivel de sistema de las redes de regulación y las complejas relaciones entre el genotipo, el fenotipo y el medio ambiente, incluidas las contribuciones de la variabilidad genética y la evolución, la regulación del “transcriptoma” y de los ARN no codificantes.

El Dr Bähler desarrolla su trabajo en el University College de Londres (UCL), en el Departamento de Investigación en Genética, Evolución y Medio Ambiente, y en asociación con los Institutos UCL de Cáncer, de Biología Estructural y Molecular, de Genética, y de Envejecimiento Saludable.

 


 

The genome is regulated at multiple levels, and cells need to integrate external and internal cues and coordinate different regulatory levels to properly exert biological functions. The information flow from a given genome (genotype) and environment to the resulting phenotype is mediated by the transcriptome, with unknown overall contribution from numerous non-coding RNAs.

Age is the major risk factor for numerous diseases and fundamental aspects of ageing are an essential part of the problem: single gene mutations and dietary restriction can extend healthy lifespan. Remarkably, conserved nutrient-signalling pathways affect longevity from yeast to mammals.

The Bähler laboratory studies genome regulation during cellular quiescence, ageing and stress response using fission yeast as a model system. They apply multiple genetic, computational and genome-wide approaches for systems-level understanding of regulatory networks and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.

He works at University College London in the Research Department of Genetics, Evolution & Environment and associated with the UCL Cancer Institute, the Institute of Structural and Molecular Biology, the UCL Genetics Institute, and the Institute of Healthy Ageing.

 

Publicaciones seleccionadas / Selected publications:

  • Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47,235–241
  • Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
  • Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
  • López-Maury L, Marguerat S, Bähler J (2008). Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nature Reviews Genetics 9, 583-593

NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it. Learn more

I understand

COOKIES POLICY

What are cookies?

A cookie is a file that is downloaded to your computer when you access certain web pages. Cookies allow a web page, among other things, to store and retrieve information about the browsing habits of a user or their equipment and, depending on the information they contain and the way they use their equipment, they can be used to recognize the user.

Types of cookies

Classification of cookies is made according to a series of categories. However, it is necessary to take into account that the same cookie can be included in more than one category.

  1. Cookies according to the entity that manages them

    Depending on the entity that manages the computer or domain from which the cookies are sent and treat the data obtained, we can distinguish:

    • Own cookies: those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which the service requested by the user is provided.
    • Third party cookies: those that are sent to the user's terminal equipment from a computer or domain that is not managed by the publisher, but by another entity that processes the data obtained through the cookies. When cookies are installed from a computer or domain managed by the publisher itself, but the information collected through them is managed by a third party, they cannot be considered as own cookies.

  2. Cookies according to the period of time they remain activated

    Depending on the length of time that they remain activated in the terminal equipment, we can distinguish:

    • Session cookies: type of cookies designed to collect and store data while the user accesses a web page. They are usually used to store information that only is kept to provide the service requested by the user on a single occasion (e.g. a list of products purchased).
    • Persistent cookies: type of cookies in which the data is still stored in the terminal and can be accessed and processed during a period defined by the person responsible for the cookie, which can range from a few minutes to several years.

  3. Cookies according to their purpose

    Depending on the purpose for which the data obtained through cookies are processed, we can distinguish between:

    • Technical cookies: those that allow the user to navigate through a web page, platform or application and the use of different options or services that exist in it, such as controlling traffic and data communication, identifying the session, access to restricted access parts, remember the elements that make up an order, perform the purchase process of an order, make a registration or participation in an event, use security elements during navigation, store content for the broadcast videos or sound or share content through social networks.
    • Personalization cookies: those that allow the user to access the service with some predefined general characteristics based on a series of criteria in the user's terminal, such as the language, the type of browser through which the user accesses the service, the regional configuration from where you access the service, etc.
    • Analytical cookies: those that allow the person responsible for them to monitor and analyse the behaviour of the users of the websites to which they are linked. The information collected through this type of cookies is used in the measurement of the activity of the websites, applications or platforms, and for the elaboration of navigation profiles of the users of said sites, applications and platforms, in order to introduce improvements in the analysis of the data of use made by the users of the service.

Cookies used on our website

The CBMSO website uses Google Analytics. Google Analytics is a simple and easy to use tool that helps website owners to measure how users interact with the content of the site. You can consult more information about the cookies used by Google Analitycs in this link.

Acceptance of the Cookies Policy

The CBMSO assumes that you accept the use of cookies if you continue browsing, considering that it is a conscious and positive action from which the user's consent is inferred. In this regard, you are previously informed that such behaviour will be interpreted that you accept the installation and use of cookies.

Knowing this information, it is possible to carry out the following actions:

How to modify the configuration of cookies

Using your browser you can restrict, block or delete cookies from any web page. In each browser the process is different, here we show you links on this particular of the most used browsers: