Thursday, 5th December 2019



Prof. Merab Kokaia

Epilepsy Center, Department of Clinical Sciences

Lund University Hospital, Sweden






2015 04 24 merab kokaia minEl genoma está regulado en múltiples niveles, y las células necesitan integrar las señales externas e internas y coordinar los diferentes niveles de regulación para ejercer adecuadamente las funciones biológicas. El flujo de información a partir de un determinado genoma (genotipo) y el medio ambiente para producir el fenotipo resultante, está mediado por el “transcriptoma”, con la contribución general, y aún desconocida, de numerosos ARN no codificantes.

El laboratorio del Prof. Kokaia explora el papel de neuropéptidos y factores neurotróficos modulando la transmisión sináptica excitatoria e inhibitoria y la epileptogénesis en cerebro. Para ello utilizan ratas y ratones transgénicos, en combinación con el uso de modelos experimentales de Epilepsia in vivo (kindling, status epilepticus) y abordajes in vitro (patch-clamp en rodajas de cerebro, optogenética). Unos de los objetivos principales de la investigación consiste en el uso de transferencia génica directa e indirecta hacia dianas concretas de neuropéptidos y factores neurotróficos en diferentes regiones cerebrales, para investigar los aspectos mecanísticos de su acción a nivel de transmisión sináptica y epileptogénesis. Su grupo también explora los efectos anticonvulsivos del abordaje mediante manipulación optogenética in vitro e in vivo en modelos animales de Epilepsia.

Los resultados de esta investigación ayudarán a entender mejor los mecanismos de epileptogénesis y podrían en un futuro dar lugar al desarrollo de nuevas estrategias basadas en terapia génica para el tratamiento de la Epilepsia.

(Más información: Dr. Alberto Martínez Serrano, This email address is being protected from spambots. You need JavaScript enabled to view it.)



Epilepsy is one of the most devastating neurological diseases affecting about 1% of the population of the western countries. Despite certain progress in antiepileptic drug development in about 30-40% of cases epileptic seizures do not respond to conventional pharmacological treatment therapies. Recently neuropeptides and neurotrophic factors emerged as strong regulators of excitatory and inhibitory synaptic transmission in the CNS thus offering a potent tool to counteract the seizure activity. However, it is not clear what the role of these agents is in mechanisms of epileptogenesis.

Kokaia’s lab explores the role of neuropeptides and neurotrophic factors in modulation of excitatory and inhibitory synaptic transmission and epileptogensis in the brain. We use rats and traNSgenic mice in combination with in vivo epilepsy models (Kindling, status epilepsitcus) and in vitro approaches (patch-clamp in brain slices, optogenetics). One of the specific aims of this research line is to use both direct and indirect targeted gene transfer of neuropeptides and neurotrophic factors into the different brain regions to investigate mechanistic aspects of their action on synaptic transmission and epileptogensis. The group also explores seizure-suppressant effects of optogenetic approach in vitro and in vivo in animal models of epilepsy.

This research will help in better understanding of the mechanisms for epileptogenesis and might lead to development of new gene therapy-based strategies for epilepsy treatment.

(More information: Dr. Alberto Martínez Serrano, This email address is being protected from spambots. You need JavaScript enabled to view it.)


Publicaciones seleccionadas / Selected publications:

  • Ritter et al. (2014) Epilepsia, 55, 1693
  • Avaliani et al (2014) Stem Cells, 32, 3088
  • Krook‐Magnuson et al (2014) Ad. Exp. Med. Biol., 813, 319
  • Ledri et al (2014) J. Neurosci., 34, 3364
  • Galanopoulou et al (2013) Epilepsia 54: 13
  • Galanopoulou et al (2012) Epilepsia 53, 571

NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it. Learn more

I understand


What are cookies?

A cookie is a file that is downloaded to your computer when you access certain web pages. Cookies allow a web page, among other things, to store and retrieve information about the browsing habits of a user or their equipment and, depending on the information they contain and the way they use their equipment, they can be used to recognize the user.

Types of cookies

Classification of cookies is made according to a series of categories. However, it is necessary to take into account that the same cookie can be included in more than one category.

  1. Cookies according to the entity that manages them

    Depending on the entity that manages the computer or domain from which the cookies are sent and treat the data obtained, we can distinguish:

    • Own cookies: those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which the service requested by the user is provided.
    • Third party cookies: those that are sent to the user's terminal equipment from a computer or domain that is not managed by the publisher, but by another entity that processes the data obtained through the cookies. When cookies are installed from a computer or domain managed by the publisher itself, but the information collected through them is managed by a third party, they cannot be considered as own cookies.

  2. Cookies according to the period of time they remain activated

    Depending on the length of time that they remain activated in the terminal equipment, we can distinguish:

    • Session cookies: type of cookies designed to collect and store data while the user accesses a web page. They are usually used to store information that only is kept to provide the service requested by the user on a single occasion (e.g. a list of products purchased).
    • Persistent cookies: type of cookies in which the data is still stored in the terminal and can be accessed and processed during a period defined by the person responsible for the cookie, which can range from a few minutes to several years.

  3. Cookies according to their purpose

    Depending on the purpose for which the data obtained through cookies are processed, we can distinguish between:

    • Technical cookies: those that allow the user to navigate through a web page, platform or application and the use of different options or services that exist in it, such as controlling traffic and data communication, identifying the session, access to restricted access parts, remember the elements that make up an order, perform the purchase process of an order, make a registration or participation in an event, use security elements during navigation, store content for the broadcast videos or sound or share content through social networks.
    • Personalization cookies: those that allow the user to access the service with some predefined general characteristics based on a series of criteria in the user's terminal, such as the language, the type of browser through which the user accesses the service, the regional configuration from where you access the service, etc.
    • Analytical cookies: those that allow the person responsible for them to monitor and analyse the behaviour of the users of the websites to which they are linked. The information collected through this type of cookies is used in the measurement of the activity of the websites, applications or platforms, and for the elaboration of navigation profiles of the users of said sites, applications and platforms, in order to introduce improvements in the analysis of the data of use made by the users of the service.

Cookies used on our website

The CBMSO website uses Google Analytics. Google Analytics is a simple and easy to use tool that helps website owners to measure how users interact with the content of the site. You can consult more information about the cookies used by Google Analitycs in this link.

Acceptance of the Cookies Policy

The CBMSO assumes that you accept the use of cookies if you continue browsing, considering that it is a conscious and positive action from which the user's consent is inferred. In this regard, you are previously informed that such behaviour will be interpreted that you accept the installation and use of cookies.

Knowing this information, it is possible to carry out the following actions:

How to modify the configuration of cookies

Using your browser you can restrict, block or delete cookies from any web page. In each browser the process is different, here we show you links on this particular of the most used browsers: