Thursday, 5th December 2019



Prof. Luis Aragón

MRC Clinical Sciences Centre

Imperial College London, UK





2015 12 04 Luis Aragon minEl Dr. Luis Aragón es investigador del MRC Clinical Sciences Centre y Catedrático de Genética del Imperial College, Londres, Reino Unido. Es también miembro de la Organización Europea de Biología Molecular (EMBO). El objetivo principal de su trabajo es el estudio de los mecanismos moleculares que controlan la correcta segregación de los cromosomas en cada división celular. Para ello, utiliza la levadura Saccharomyces cerevisiae como modelo eucariótico. La investigación de su grupo está centrada en el análisis de la función y regulación de los complejos proteicos cohesina, condensina y SMC5/SMC6, así como en la conexión de los mismos con los mecanismos que regulan la progresión en el ciclo celular. Sus aportaciones en este campo han sido muy relevantes para entender cómo las células previenen la aneuplodía, la cual está asociada con el desarrollo del cáncer y defectos en el nacimiento.



Dr. Luis Aragón is a researcher of the MRC Clinical Sciences Centre and a Professor of Genetics at the Imperial College, London, United Kingdom. He is also a member of the European Molecular Biology Organization (EMBO). The main goal of his work is the study of the molecular mechanisms that control faithful chromosome segregation in every cell division. For this purpose, he uses the yeast Saccharomyces cerevisiae as a eukaryotic model. The research of his group is focussed on the analysis of the function and regulation of the protein complexes cohesin, condensin and SMC5/SMC6, as well as on the connection of them with the mechanisms that regulate cell cycle progression. His contributions in this field have been highly relevant to understand how cells prevent aneuploidy, a condition that is associated with the development of cancer and birth defects.


Publicaciones seleccionadas / Selected publications:

  • McAleenan A, Clemente-Blanco A, Cordon-Preciado V, Sen N, Esteras M, Jarmuz A, Aragón L. (2013) "Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin". Nature 493:250-4
  • Aragon L, Martinez-Perez E, Merkenschlager M (2013) "Condensin, cohesin and the control of chromatin states". Curr Opin Genet Dev 23:204-11
  • McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Liu IC, Sen N, Leonard J, Jarmuz A, Aragón L (2012) "SUMOylation of the α-kleisin subunit of cohesin is required for DNA damage-induced cohesion". Curr Biol 22:1564-75
  • Baxter J, Aragón L (2012) "A model for chromosome condensation based on the interplay between condensin and topoisomerase II". Trends Genet 28: 110-7
  • Clemente-Blanco A, Sen N, Mayan-Santos M, Sacristán MP, Graham B, Jarmuz A, Giess A, Webb E, Game L, Eick D, Bueno A, Merkenschlager M, Aragón L (2011) "Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription". Nat Cell Biol 13: 1450-6
  • Baxter J, Sen N, Martínez VL, De Carandini ME, Schvartzman JB, Diffley JF, Aragón L (2011) "Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes". Science 331:1328-32
  • Clemente-Blanco A, Mayán-Santos M, Schneider DA, Machín F, Jarmuz A, Tschochner H, Aragón L (2009) "Cdc14 inhibits transcription by RNA polymerase I during anaphase". Nature 458: 219-22

NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it. Learn more

I understand


What are cookies?

A cookie is a file that is downloaded to your computer when you access certain web pages. Cookies allow a web page, among other things, to store and retrieve information about the browsing habits of a user or their equipment and, depending on the information they contain and the way they use their equipment, they can be used to recognize the user.

Types of cookies

Classification of cookies is made according to a series of categories. However, it is necessary to take into account that the same cookie can be included in more than one category.

  1. Cookies according to the entity that manages them

    Depending on the entity that manages the computer or domain from which the cookies are sent and treat the data obtained, we can distinguish:

    • Own cookies: those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which the service requested by the user is provided.
    • Third party cookies: those that are sent to the user's terminal equipment from a computer or domain that is not managed by the publisher, but by another entity that processes the data obtained through the cookies. When cookies are installed from a computer or domain managed by the publisher itself, but the information collected through them is managed by a third party, they cannot be considered as own cookies.

  2. Cookies according to the period of time they remain activated

    Depending on the length of time that they remain activated in the terminal equipment, we can distinguish:

    • Session cookies: type of cookies designed to collect and store data while the user accesses a web page. They are usually used to store information that only is kept to provide the service requested by the user on a single occasion (e.g. a list of products purchased).
    • Persistent cookies: type of cookies in which the data is still stored in the terminal and can be accessed and processed during a period defined by the person responsible for the cookie, which can range from a few minutes to several years.

  3. Cookies according to their purpose

    Depending on the purpose for which the data obtained through cookies are processed, we can distinguish between:

    • Technical cookies: those that allow the user to navigate through a web page, platform or application and the use of different options or services that exist in it, such as controlling traffic and data communication, identifying the session, access to restricted access parts, remember the elements that make up an order, perform the purchase process of an order, make a registration or participation in an event, use security elements during navigation, store content for the broadcast videos or sound or share content through social networks.
    • Personalization cookies: those that allow the user to access the service with some predefined general characteristics based on a series of criteria in the user's terminal, such as the language, the type of browser through which the user accesses the service, the regional configuration from where you access the service, etc.
    • Analytical cookies: those that allow the person responsible for them to monitor and analyse the behaviour of the users of the websites to which they are linked. The information collected through this type of cookies is used in the measurement of the activity of the websites, applications or platforms, and for the elaboration of navigation profiles of the users of said sites, applications and platforms, in order to introduce improvements in the analysis of the data of use made by the users of the service.

Cookies used on our website

The CBMSO website uses Google Analytics. Google Analytics is a simple and easy to use tool that helps website owners to measure how users interact with the content of the site. You can consult more information about the cookies used by Google Analitycs in this link.

Acceptance of the Cookies Policy

The CBMSO assumes that you accept the use of cookies if you continue browsing, considering that it is a conscious and positive action from which the user's consent is inferred. In this regard, you are previously informed that such behaviour will be interpreted that you accept the installation and use of cookies.

Knowing this information, it is possible to carry out the following actions:

How to modify the configuration of cookies

Using your browser you can restrict, block or delete cookies from any web page. In each browser the process is different, here we show you links on this particular of the most used browsers: