Tuesday, 10th December 2019

2016.2.12.adolfo garcia sastre


Prof. Adolfo García Sastre

Icahn School of Medicine at Mount Sinai

New York. USA





2016 02 12 Adolfo Garcia Sastre MinEl Dr. García-Sastre tiene una destacada trayectoria en las áreas de virología, inmunología y vacunas. Su carrera investigadora conduce a más de 450 publicaciones, que contribuyen a una mejor comprensión de 1) la patogénesis molecular de virus tales como influenza, ébola, el virus del dengue y del virus de la fiebre hemorrágica Crimea-Congo y 2) los mecanismos celulares que regulan la inducción y regulación de las respuestas antivirales.

El Dr. García-Sastre dirige el equipo que dio lugar a la reconstrucción del virus de la gripe que produjo la pandemia de 1918, así como la caracterización de los factores que influyen en su virulencia y transmisión. La publicación resultante se seleccionó papel del año por la revista The Lancet, y representa la primera vez que un organismo extinto ha sido regenerada a partir de material genético. Es importante destacar que la caracterización de este virus reveló importantes datos sobre el tropismo de huésped y de los marcadores del virus, lo que permitió predecir que el brote del virus H1N1 pandémico de 2009 no iba a ser altamente virulento, ya que carece de algunos de los marcadores de virulencia del virus de 1918. El laboratorio del Dr. García-Sastre sigue siendo un líder en el campo de la patogénesis molecular de influenza, describiendo, por ejemplo, el papel fundamental que desempeña la glicosilación en el escape de la inmunidad adaptativa y en su virulencia. Además, su laboratorio ha sido pionero en la inserción orientada de secuencias de microARN humanos en el genoma de un virus, entendido como una herramienta de contención biológica molecular que permite la investigación con cepas virales muy patogénicas de un modo seguro.



Dr. García-Sastre has an outstanding record of contributions to the areas of virology, vaccines and immunology. His independent investigator career led to more than 450 publications to date. His published work has contributed to better understand 1) the molecular pathogenesis of emerging viral pathogens, specially influenza virus, but also ebolavirus, dengue virus and Crimean-Congo haemorrhagic fever virus; and 2) the cellular mechanisms governing induction and regulation of antimicrobial responses.

Dr. García-Sastre lead the team that resulted in the reconstruction of the 1918 pandemic influenza virus, and the characterization of the factors that influence virulence and transmission of pandemic influenza viruses. The resulting publication was selected paper of the year by Lancet and represents the first time that an extinct organism has been regenerated from genetic material. Importantly, the characterization of this virus revealed important host tropism and virulence markers of influenza virus which allowed to predict that the more recent pandemic H1N1 virus of 2009 was not going to be highly virulent, as it lacks some of the virulence markers of 1918 H1N1 viruses. Dr. García-Sastre’s lab continues to be a leader in the field of influenza virus molecular pathogenesis. For instance, the critical role that glycosylation plays in influenza virus escape from adaptive immunity and in virulence was determined recently by his lab. In addition, his lab has pioneered the insertion of human specific microRNA targeting sequences into the genome of a virus as a molecular bio-containment tool that allows for safer research with viral strains of high pathogenic concern.

Más información / More information: Dr. Yolanda Revilla Novella, This email address is being protected from spambots. You need JavaScript enabled to view it.


Publicaciones seleccionadas / Selected publications:

  • Y. Nakaya, T. Nakaya, M.-S. Park, J. Cros, J. Imanishi, P. Palese & A. García-Sastre: Induction of cellular immune responses to SIV gag by two recombinant negative-strand RNA virus vectors. J. Virol., 78, 9366-9375 (2004). PMC506935.
  • A. Vigil, O. Martinez, M. A. Chua & A. García-Sastre. Recombinant Newcastle disease virus as a vaccine vector for cancer therapy. Mol. Ther. 16, 1883-1890 (2008). PMC2878970.
  • M. Laurent-Rolle, J. Morrison, R. Rajsbaum, J. M. L. Macleod, G. Pisanelli, A. Pham, J. Ayllon, L. Miorin, C. Martinez, B. R. tenOever & A. García-Sastre. The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by Type I interferon. Cell Host and Microbe, 16:314-327(2014). PMC4176702.
  • R. A. Langlois, R. A. Albrecht, B. Kimble, T. Sutton, J. S. Shapiro, C. Finch, M. Angel, M. A. Chua, A. S. Gonzalez-Reiche, K. Xu, D. Perez*, A. García-Sastre*, B. R. tenOever* (co-corresponding authors). Micro RNA-based strategy to mitigate the risk of gain-of-function influenza studies. Nat. Biotech., 31:844-847 (2013). PMC3808852.
  • A. Baum, R. Sachidanandam & A. García-Sastre. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc. Natl. Acad. Sci. (USA), 107, 16303-16308, 2010). PMC2941304.
  • J. R. Patel, A. Jaine, Y-Y. Chou, A. Baum, T. Ha & A. García-Sastre. ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon. EMBO Reports, 14:780-787 (2013). PMC3790048.
  • G. A. Versteeg, R. Rajsbaum, M. T. Sánchez-Aparicio1, A. M. Maestre, J. Valdiviezo, M. Shi, K.-S. Inn, A. Fernández-Sesma, J. Jung & A. García-Sastre. The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors. Immunity, 38:384-398 (2013). PMC3584420.
  • R. Rajsbaum, G. A. Versteeg, S. Schmid, A. M. Maestre, A. Belicha-Villanueva, C. Martínez-Romero, J. R. Patel, J. Morrison, G. Pisanelli, L. Miorin, M. Laurent-Rolle, H. M. Moulton, D. A. Stein, A. Fernandez-Sesma, B. R. tenOever & A. García-Sastre. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity, 40:880-895 (2014). PMC4114019.
  • S. Cuadrado-Castano, J. Ayllon, M. Mansour, J. de la Iglesia-Vicente, S. Jordan, S. Tripathi, A. García-Sastre* & E. Villar. Enhancement of the pro-apoptotic properties of Newcastle disease virus promotes tumor remission in syngeneic murine cancer models. Mol. Cancer Ther., 14(5):1247-1258 (2015). PMC4425597. *Corresponding author

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