Tuesday, 10th December 2019

2016.7.1.fiona m watt


Prof. Fiona M. Watt

King's College London, Guy's Hospital

London, UK





2016 07 01 Fiona M Watt minEn los últimos 30 años estudios en los procesos de homeostásis en la piel, el órgano más extenso de nuestro cuerpo, han contribuído de manera determinante a nuestra comprensión de la biología de las células madre. La piel está formada por dos capas, la capa externa, o epidermis, formada por un epitelio estratificado y las estructuras asociadas (como folículos pilosos o glándulas sudoríparas), y la dermis, situada por debajo de la epidermis, y separada de la misma por una membrana basal altamente organizada. Estas estructuras están formadas por un número relativamente discreto de tipos celulares diferenciados, que derivan de varias poblaciones de células madre situadas en distintos nichos en la piel. El grupo de Fiona Watt ha contribuído de manera decisiva a la identificación de las distintas poblaciones de células madre que dan lugar a las células de la piel. Sus estudios han permitido la identificación de marcadores específicos para cada uno de los tipos de células madre de la piel, y han contribuído a la comprensión de los mecanismos moleculares involucrados en controlar el comportamiento de las células madre, tanto en condiciones de homeostásis, como en situaciones patológicas. Fiona Watt dirige desde 2012 el Centro de Medicina Regenerativa y Células Madre del King’s College London, y entre otras muchas distinciones es miembro de EMBO y de la Royal Society.



In the last thirty years, studies on the skin have greatly contributed to our understanding of stem cell biology. The skin is composed by two layers, the externally located epidermis and its adnexal structures (hair follicles and sweat glands), and the dermis, located just below. These structures are formed by a discrete number of differentiated cell types that derive from stem cells located at different niches within this organ. The work from Fiona Watt and her group has decisively contributed over these years to the identification of the stem cell populations essential for skin homeostasis and function. They have identified markers for each of the stem cell populations in the skin, followed their dynamics of differentiation and uncovered many of the molecular mechanisms involved in the control of stem cell behaviour, not only under conditions of normal skin homeostasis, but also under pathological conditions. Fiona Watt is, since 2012, Director for the Centre for Stem Cells and Regenerative Medicine at King’s College London. She is an EMBO Member and Fellow for the Royal Society and the Academy of Medical Sciences, among many other distinctions.

Más información / More information: Florencia Cavodeassi, This email address is being protected from spambots. You need JavaScript enabled to view it.


Publicaciones seleccionadas / Selected publications:

  • Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM. Cell Rep. 2016 Jan 12;14(2):269-­81
  • Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1501-­9.
  • Liakath-­Ali K, Vancollie VE, Heath E, Smedley DP, Estabel J, Sunter D, Ditommaso T, White JK, Ramirez-­Solis R, Smyth I, Steel KP, Watt FM. Nat Commun. 2014 Apr 11;5:3540.
  • Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson­‐Smith AC, Watt FM. Nature. 2013 Dec 12;504(7479):277-81.
  • Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM. Development. 2013 Apr;140(7):1433-­44.
  • Gomez C, Chua W, Miremadi A, Quist S, Headon DJ, Watt FM. Stem Cell Reports. 2013 Jun 4;1(1):19-27.
  • Mulder KW, Wang X, Escriu C, Ito Y, Schwarz RF, Gillis J, Sirokmány G, Donati G, Uribe­‐Lewis S, Pavlidis P, Murrell A, Markowetz F, Watt FM. Nat Cell Biol. 2012 Jun 24;14(7):753-­63.
  • Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM. Cell. 2011 Feb 18;144(4):577­‐89.
  • Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM. Cell Stem Cell. 2009 May 8;4(5):427­‐39.

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