Wednesday, 12th December 2018

2017.02.17 jesus vazquez

 

Prof. Jesús Vázquez

Centro Nacional de Investigaciones Cardiovasculares (CNIC)

 

 

 

 

 

2017 02 17 Jesus Vazquez minEl grupo de Jesús Vázquez ha sido pionero en el desarrollo de la espectrometría de masas y la proteómica en España. Su laboratorio ha hecho importantes contribuciones en esos campos, investigando los mecanismos de fragmentación y la secuenciación de novo de péptidos y el anállisis de modificaciones postraduccionales. En la actualidad Jesús Vázquez trabaja en el desarrollo de técnicas de alto rendimiento para el análisis profundo del proteoma, incluyendo nuevos algoritmos bioinformáticos para la identificación y cuantificación de proteínas y su estudio mediante biología de sistemas, y para el estudio masivo de modificaciones postraduccionales.

Su grupo está usando estas tecnologías para estudiar la evolución del corazón después de un infarto, los efectos a nivel molecular de tratamientos protectores y el impacto de las modificaciones postraduccionales en estos procesos.

El Dr. Vázquez también ha desarrollado una plataforma de proteómica traslacional para el estudio de grandes cohortes de pacientes. Su laboratorio está estudiando a nivel molecular las fases más tempranas de la aterosclerosis, y buscando factores proteicos, lipídicos y metabólicos que correlacionan con el avance de la enfermedad en sus estados subclínico y clínico antes de un evento agudo. También está estudiando los cambios moleculares que tienen lugar en la pared aórtica afectada por placa en diferentes estados de evolución.

Finalmente, el grupo del Dr. Vázquez estudia los mecanismos que regulan el ensamblaje y superensamblaje de los complejos de la cadena de transporte electrónico mitocondrial, usando Blue­‐DiS, una nueva tecnología que permite el análisis del interactoma y la implicación de factores proteínicos, isoformas y modificaciones postraduccionales con un grado de detalle molecular sin precedentes.

Jesús Vázquez es Profesor de Investigación del CSIC y se incorporó al Centro Nacional de Investigaciones Cardiovasculares en 2011 como Full Professor, donde lidera el Laboratorio de Proteómica Cardiovascular, y es director de las Unidades de Proteómica y Metabolómica del CNIC.

 


 

The group of Dr. Jesús Vázquez has played a pioneering role in the development of protein chemistry, mass spectrometry and proteomics in Spain. His laboratory has made relevant contributions to the field, addressing subjects such as peptide fragmentation mechanisms, de novo peptide sequencing, and analysis of posttranslational modifications. He is currently working on novel high-­throughput quantitative approaches for the dynamic analysis of the deep proteome, including novel bioinformatics algorithms for protein identification, quantification and systems biology interpretation in very large numbers of samples, and for the study of posttranslational modifications using novel hypothesis­‐free approaches.

He is currently using these proteomics technologies to study the molecular events taking place in heart after infarction, using a pig model of ischemia reperfusion, and the effects at the molecular level of protective treatments, including the impact on postranslational modifications.

He has also developed a translational proteomics platform, with which he is studying the molecular mechanisms implicated in early atherosclerosis, searching for protein, metabolic and lipidic factors that correlate with the extent of subclinical atherosclerotic events such as calcium deposition and plaque formation and activity, in the setting of the PESA project. He is also studying other models of atherosclerosis in different clinical stages, and molecular changes taking place in aorta containing plaques in early stages of formation, in the plaque itself and in its secretome.

Finally, he is studying the molecular mechanisms that regulate assembly and superassembly of the complexes of the electron transport chain in mitochondria, using Blue­‐DiS, an advanced technology that allows the analysis of the interactome and the implication of protein factors, isoforms and postranslational modifications with unprecedented molecular detail.

Jesús Vázquez is Profesor de Investigación of the CSIC. He joined the Centro Nacional de Investigaciones Cardiovasculares as a Full Professor in 2011, where he leads the Cardiovascular Proteomics laboratory and is director of the Proteomics and Metabolomics Units.

 

Publicaciones recientes / Recent publications:

  • Cogliati S*, Calvo E*, Loureiro M, Guaras AM, Nieto-­‐Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vazquez J*, Enriquez JA* (JV and JAE are co­‐corresponding authors). Mechanism of super­‐assembly of respiratory complexes III and IV. Nature (2016) 539:579-­82.
  • Latorre-­Pellicer A, Moreno­‐Loshuertos R, Lechuga­‐Vieco AV, Sánchez­‐Cabo F, Torroja C, Acín­‐Pérez R, Calvo E, Aix E, González­‐ Guerra A, Logan A, Bernad-­Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez­‐Martos A, Fernández­‐Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 525:561-­65.
  • Cibrian D, Saiz ML, de la Fuente H, Sanchez-Diaz R, Moreno­‐Gonzalo O, Jorge I, Ferrarini A, Vazquez J, Punzon C, Fresno M, Vicente­‐Manzanares M, Dauden E, Fernandez­‐Salguero PM, Martin P, Sanchez­‐Madrid F. CD69 controls the uptake of L­‐ tryptophan through LAT1-CD98 and AhR­‐dependent secretion of IL­‐22 in psoriasis. Nat Immunol (2016) 17:985-­96.
  • Calvo E, Garcia-Alvarez A, Vazquez J. The Quest for Metabolic Biomarkers of Pulmonary Hypertension. J Am Coll Cardiol (2016) 67:190­‐2.
  • García-­Marqués F, Trevisan­‐Herraz M, Martínez­‐Martínez S, Camafeita E, Jorge I, Lopéz JA, Méndez­‐Barbero N, Méndez­‐Ferrer S, Del Pozo MÁ, Ibáñez B, Andrés V, Sánchez­‐Madrid F, Redondo JM, Bonzon-Kulichenko E, Vázquez J. A novel systems­‐biology algorithm for the analysis of coordinated protein responses using quantitative proteomics. Mol Cell Proteomics (2016) 15:1740­‐60.
  • Bonzon-Kulichenko E, Garcia-­Marques F, Trevisan­‐Herraz M, Vazquez J. Revisiting Peptide Identification by High­‐Accuracy Mass Spectrometry: Problems Associated with the Use of Narrow Mass Precursor Windows. J Proteome Res (2015) 14:700-­10.

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