Wednesday, 12th December 2018

Marie Skłodowska-Curie PhD position

Open position for: Marie Skłodowska-Curie PhD position at the Laboratory of Human Neural Stem Cells (Center of Molecular Biology “Severo Ochoa” and Autonomous University of Madrid).

Title: “Improving reproducibility of cerebral organoids to study neurological disorders”.

Contract: PhD scholarship at the Laboratory of Human Neural Stem Cells, Department of Molecular Neuropathology (Center of Molecular Biology “Severo Ochoa”, CBMSO), and Department of Molecular Biology (Autonomous University of Madrid, UAM). Start date during March 2019.

Closing date for receipt of applications: December 1 2018.

Job Summary:

Applications are invited from suitably qualified candidates for a position funded by the Marie Skłodowska-Curie project “ASCTN-Training” within the Horizon 2020 Programme of the European Union, starting latest March 1st, 2019. The appointment will be on a temporary basis for a maximum period of 3 years (PhD student) and will be placed at the Department of Molecular Neuropathology (Center of Molecular Biology “Severo Ochoa”, CBMSO), and Department of Molecular Biology (Autonomous University of Madrid, UAM) (Madrid, Spain).

ASCTN-Training is a four-year project, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Innovative Training Network and Grant Agreement No. 813851. ASCTN-Training is addressing existing gaps within Human Stem Cell-based Neuronal disorders (NDs) Modelling (NDM) for research to develop new medicines for the treatment of neurological disorders (e.g. Parkinson´s (PD), Huntington´s (HD) and Demyelination’s (DM) diseases), which occur as a result of acute or progressive loss of cells, glial or neuronal, and structures and function in the brain. ASCTN-Training sets out with the ambition to educate and train students within and across different scientific disciplines: biotechnology (Human Pluripotent Stem Cells (hPSCs) neuronal and glial differentiation using brain-on-chip technology and microfluidics, 3D tissue engineering/cerebral organoids and nano-engineering of culture conditions), molecular biology (Ex vivo gene expression, Direct cellular reprograming, mouse genetic modification, single cell analysis), In vivo mouse manipulations (Animal models of NDs, stem cell transplants into the brain, scaffold implantation, direct tissue engineering).

Please send applications to Alberto Martínez at This email address is being protected from spambots. You need JavaScript enabled to view it..

 

Oferta de Contrato Investigador/a Posdoctoral Asociado a Proyecto

Se oferta un contrato de investigador posdoctoral asociado al proyecto RTC-2017-6292-1 “Validación de dianas farmacológicas neuroinflamatorias para el tratamiento del dolor crónico (INFLAPAIN)”, financiado por el Ministerio de Economía y Competitividad y FEDER.

Condiciones del contrato:

  • Duración 6 meses a tiempo completo
  • El trabajo se desarrollará del 3 de noviembre de 2018 al 2 de mayo de 2019
  • Salario aproximado: 2.228,53 euros brutos/mes

Lugar de trabajo:

  • Grupo de investigación: Manuel Fresno
  • Centro de Biología Molecular “Severo Ochoa”
  • Universidad Autónoma de Madrid

Funciones:

  • Papel de los Toll-like receptores en dolor asociado a inflamación

Requisitos:

  • Doctor en Bioquímica o Biología
  • Experiencia en biología molecular (clonajes), técnicas de bioquímica, cultivos celulares, cultivos primarios de células del sistema nervioso CRISPR/Cas central de roedores
  • Experiencia en microscopia óptica y confocal
  • Se valorará estar en posesión de la categoría C para la utilización de animales de experimentación
  • Se valorará experiencia en bioinformática
  • Nivel alto de inglés

Los interesados deberán enviar su CV hasta el próximo 18 de octubre de 2018 a la dirección: This email address is being protected from spambots. You need JavaScript enabled to view it..

Los candidatos podrán ser convocados a una entrevista personal.

 

Oferta de Contrato de Técnico

Se oferta un contrato de técnico con cargo al proyecto SAF2016-76028-R de la doctora Laura Formentini, investigadora Ramón y Cajal en el Departamento de Biología Molecular, UAM.

Condiciones del contrato:

  • Duración de 14 meses, a jornada completa
  • El trabajo se desarrollará del 1 de noviembre de 2018 al 31 de diciembre de 2019
  • Salario: 1450 € brutos / mes

Lugar de trabajo:

  • Centro de Biología Molecular Severo Ochoa
  • Universidad Autónoma de Madrid

Funciones:

  • Estudios in vitro/in vivo con la finalidad de investigar el papel de la bioenergética mitocondrial en enfermedades raras y metabólicas
  • Estudios en cultivos primarios de miocitos derivados de tejido muscular esquelético de ratón
  • Determinación de la expresión génica y proteica (qRT-PCR, western blots, inmunohistoquimica, inmunofluorecencia, etc.)
  • Mantenimiento del laboratorio y de la colonia de ratones
  • Preparación de búferes y material de uso común

Requisitos imprescindibles:

  • Experiencia demostrada como técnico o ayudante de laboratorio
  • Experiencia en mantenimiento de colonias de ratones
  • Posesión de categoría B, C o función d de capacitación al manejo de los animales de experimentación (según RD53/2013)
  • Experiencia demostrada en cultivos celulares

Requisitos valorados:

  • Se valorará positivamente el dominio de técnicas de clonaje y Crispr/Cas
  • Se valorará positivamente el dominio de técnicas de biología molecular (western blots, PCR, inmunohistoquimica, inmunofluorecencia etc.)

Los interesados deberán enviar su Currículum Vitae y una copia de su título hasta el 15 de octubre 2018 a la dirección This email address is being protected from spambots. You need JavaScript enabled to view it., indicando en el asunto “CONTRATO”. Los candidatos podrán ser convocados a una entrevista personal.

 

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