Cabecera 2019 CBMSO CSIC UAM

Thursday, 24th October 2019

A Cell Biology and Immunology - Overview

Overview

The department of Cell Biology and Immunology (CBI) gathers 20 groups interested in studying molecular mechanisms of mammalian cell organization and function. The research groups that compose the CBI share common experimental approximations, technologies and an interest in a limited set of cell processes: differentiation, motility, polarity, cell-cell interaction and signal transduction. The CBI’s research activities are structured around two major areas of research interest: the immune system and cell processes. The groups interested in the immune system tackle various fundamental aspects including how immune cells differentiate from hematopoietic precursors, how immune cells interact with parasites and viruses and the processes of antigen presentation and antigen recognition. The encounter with the antigen and the resulting activation of intracellular signaling pathways is also studied and compared with other cell systems. The groups studying cell processes focus on dissecting the molecular mechanisms that govern cell polarization, intracellular trafficking of proteins, cell adhesion and cell migration. These processes are studied in immune cells, epithelial cells and the endothelium. An important part of the CBI is dedicated to the T cell as a model system: T cell development and its perturbation during malignant transformation, mechanisms of antigen presentation by MHC molecules linked to arthropathies, antigen presentation of viral proteins and mechanisms of cyotoxic T cell killing, mechanisms of T cell adhesion and its regulation by tetraspanins, and T cell receptor signaling mechanisms influencing differentiation to pro-inflammatory effector T cells. Viruses and intracellular protozoa affecting inflammation and causing cardiac damage are also being investigated as models of perturbation of the immune system. Interestingly, inflammation and the cardiovascular system are also approached from the side of endothelial cells and signaling mechanisms, with repercussions on diabetes and obesity. Finally, the cytoskeleton, the polarization of epithelial cells, intracellular vesicular transport, and the loss of epithelial features during epithelial-to-mesenchimal transition and its impact on fibrosis and cancer metastasis are being actively investigated. The research carried out in the CBI has a clear translational angle, applying to cancer, inflammation and autoimmune diseases.

Overview

The Department of Cell Biology and Immunology (CBI) gathers 20 groups interested in studying molecular mechanisms of mammalian cell organization and function. The research groups that compose the CBI share common experimental approximations, technologies and an interest in a limited set of cell processes: differentiation, motility, polarity, cell-cell interaction and signal transduction. The CBI’s research activities are structured around two major areas of research interest: the immune system and cell processes.

Read more about the Dept. of Cell Biology and Immunology

Department's shared resources databases:

 

 Director of the Dept.: María Luisa Toribio

Group Leader 

   Research
Balbino Alarcón   Signal transduction by the T-cell antigen receptor
Miguel A. Alonso   Cell polarity
Pedro Bonay   Functional Glycogenomics
Carlos Cabañas   Functional interactions between tetraspanin CD9 and cell adhesion molecules
Susana Cadenas   Mitochondrial pathophysiology
César Cobaleda   Cellular plasticity in development and cancer
Isabel Correas   Cytoskeleton-plasma membrane interactions
José M. Cuezva    Biogenesis and function of mitochondria and its role in pathology
Margarita del Val   Viral immunology
José Fernández-Piqueras   Genetics susceptibility in complex diseases: genes involved in susceptibility to T-cell lymphoblastic lymphoma
Manuel Fresno   Regulation and function of proinflammatory mediators and their involvement in immune and inflammatory mediated diseases
Miguel A. Íñiguez   Prostanoids actions in inflammatory processes
José María Izquierdo   Molecular and cellular basis of the physio(patho)logy associated with the expression of intracellular antigens
Santiago Lamas   Molecular Pathophysiology of Fibrosis
Manuel López-Cabrera   Role of the epithelial to mesenchymal transition (EMT) of mesothelial cells in peritoneal fibrosis and metastasis
José A. López de Castro   Mechanism of association of HLA-B27 with spondyloarthropathies (JALC)
Federico Mayor Jr.   G protein-coupled receptor networks: signal transduction and pathophysiological implications
Jaime Millán   Cell biology of inflammation
María Mittelbrunn   Immunometabolism and Inflammation Laboratory
María N. Navarro   Intracellular Signalling in Inflammatory Processes
Fernando Rodríguez-Pascual   Extracellular matrix remodeling in the cardiovascular system
Juan M. Serrador   Nitric oxide and adaptive immune response: regulation and function of nitric oxide synthase activity in the differentiation and activation of T-lymphocytes
María L. Toribio   Human hematolymphoid development
Ignacio V. Sandoval   Metabolic homeostasis
María Yáñez-Mó    Tetraspanin-enriched membrane microdomains in extracellular vesicles and cell adhesion and migration

 

 

                      Project Leaders 
      Nuria Gironés
(associated with Manuel Fresno)
Cristina Murga
(associated with Federico Mayor)
               Catalina Ribas
(Federico Mayor Jr. lab.)
Hisse M. van Santen
(Balbino Alarcón lab.)

 

 

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