Monday, 18th December 2017

Virology and Microbiology - Tables

Overview

Infectious diseases remain an important cause of human morbidity and mortality, and are responsible for major economic losses to livestock owners all over the world.  We carry out high-quality basic research in molecular virology/microbiology covering all relevant aspects of the interactions of microbes with their hosts and environment, from the molecular basis of viral disease in humans and animals (cell receptor recognition, viral replication, transcriptional and translational regulation, assembly and mechanisms employed by infectious agents to evade immunity) to the biochemical analysis of regulatory processes involved in controlling bacterial growth, morphogenesis, cell division, antibiotic resistance and sporulation.  

Read more about the Dept. of Virology and Microbiology....

Director of the Dept.: Francisco Sobrino

Group Leader 

   Research
Antonio Alcamí  Viral modulation of the immune response
José M. Almendral  Molecular basis of parvovirus pathogenesis and anticancer potential
Ricardo Amils  Molecular ecology of extreme environments
Juan A. Ayala  Bacterial cell division and antibiotic resistance
José Berenguer  Biotechnology and genetics of extreme thermophiles
Esteban Domingo  Genetic variability of RNA viruses
Paulino Gómez-Puertas Molecular modelling group
María Fernández-Lobato  Yeast enzymes bioengineering to generate bioactive compounds
Mauricio G. Mateu  Virus engineering and Nanobiotechnology
Wilfried J.J. Meijer  Effects of extrachromosomal elements on behavior of its host and mechanisms of horizontal gene transfer in Bacillus
Luis Menéndez-Arias  Human immunodeficiency virus reverse transcriptase and antiretroviral therapy
Yolanda Revilla   Virus Cell Interaction. The African swine fever virus model
Francisco Sobrino
New strategies for prevention and control of viral diseases: foot-and-mouth disease virus as a model
Iván Ventoso  mRNA structure and translation control in biological systems

 

 

                      Project Leaders 
            Alberto López-Bueno
(José María Almendral lab.)
Angel L. López Carrascosa
(Yolanda Revilla lab)
Margarita Sáiz
(Francisco Sobrino lab.)

Virology and Microbiology - Overview

Overview

Infectious diseases remain an important cause of human morbidity and mortality, and are responsible for major economic losses to livestock owners all over the world. We carry out high-quality basic research in molecular virology/microbiology covering all relevant aspects of the interactions of microbes with their hosts and environment, from the molecular basis of viral disease in humans and animals (cell receptor recognition, viral replication, transcriptional and translational regulation, assembly and mechanisms employed by infectious agents to evade immunity) to the biochemical analysis of regulatory processes involved in controlling bacterial growth, morphogenesis, cell division, antibiotic resistance and sporulation. These studies are complemented by genomic and transcriptome analysis of microbial populations in different environments (e.g., studies of viral quasispecies in infected cell cultures and natural hosts and metagenomic analysis of microbes in extreme environments). 

We take a multidisciplinary approach, studying viruses from different families: poxvirus, herpesvirus, picornavirus, parvovirus, retrovirus, asfarvirus, togavirus and arenavirus, as well as cellular microorganisms (Escherichia coli, Pseudomonas aeruginosa, Bacteroides fragilis, Listeria monocytogenes, Vibrio cholerae, Bacillus subtilis, Thermus thermophilus, Asticcacaulis biprosthecium, Streptomyces sp., Rhodotorula sp., Schawannoidmyces occidentalis, iron and sulphur oxidizers, etc.).

As a whole, our studies are expected to contribute to the development of novel antimicrobial drugs and vaccines, as well as enzymes and other reagents with biotechnological and industrial applications.  

The research carried out in the Department of Virology and Microbiology is organized into five major areas:

(1) Population dynamics and characterization of microbiomes: Genetic variability of RNA and single-stranded DNA viruses and metagenomic analysis in extreme environments.

(2) Virus-host interactions: Immunity and modulation of the immune response: Modulation of the immune response by viruses, African swine fever virus as a model of evasion and protection, and novel vaccines against foot-and-mouth disease virus.

(3) Basic molecular and cellular virology: Viral entry, genome replication, translation regulation and viral tropism, and capsid formation and morphogenesis.

(4) Basic molecular and cellular bacteriology: Bacterial morphogenesis, cell division and antibiotics resistance, and extrachromosomal elements in Bacillus subtilis.

(5) Biotechnological applications in virology and microbiology: Viral capsids as nanocontainers, fidelity of reverse transcriptases, genetics of extreme thermophiles, usage of acidophile microorganisms in biomining, and production of prebiotic oligosaccharides from non-conventional yeasts.