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Signaling pathways in mouse models of metabolic and cardiovascular pathologies

Research summary:

Our group has been working for the past decade on analyzing some of the cellular processes and intracellular signal transduction pathways that control and regulate the response of an organism to physiological and pathological processes involving metabolic rewiring. We have focused, in particular, on the integration that occurs among different organs during obesity, insulin resistance and cardiovascular disease conditions.

Using diets to model human disease, our group has studied the response of several metabollicaly-relevant organs and tissues as the heart, adipose tissue or the liver to pathological insults such as nutrient overload. We have also investigated the molecular events controlling the adaptation of the body to physiological responses such as fasting and calorie restriction.

We are paying particular attention to the molecular determinants that are key to how aged animals control these physiopathological responses in comparison to young mice. Specifically, we analyze molecular and cellular events that may differ between aged and young animals in relationship with metabolic responses such as glucose handling, adiposity, vascular function and cardiac or hepatic steatosis among others.

Finally, we have recently initiated a research line aimed at deciphering some of the tissue, cell and molecular aspects that differentiate female and male responses to nutrient overload, insulin resistance, obesity and cardiovascular health.


Graphical summary of recent contributions of our group regarding the influence of signaling cascades in the regulation of cellular and tissue processes involved in human pathophysiology (mostly performed in animal models of human disease). IR: insulin resistance; FAO, fatty acid oxidation; BAR, beta adrenergic receptor; NAFLD, non alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; NO nitric oxide.


* For external calls please dial 34 91196 followed by the extension number
Last nameNameLaboratoryExt.*e-mailProfessional category
Murga MontesinosCristina320/114.24641cmurga(at)cbm.csic.esCatedrático Universidad, GA
Portilla TundidorYadileiny3204652yportilla(at)cbm.csic.esTitulado Sup.de Actividades Técn. y Profes. GP1
Vida RuedaMª Carmen3204652mcvida(at)cbm.csic.esInvestigador Doctor

Relevant publications:

Doctoral theses:

  • Alba Concepción Arcones. "Influence of GRK2 levels in the modulation of glucose homeostasis in health and disease". Facultad de Ciencias. Universidad Autónoma de Madrid. 2021 (Mención Internacional)
  • Marta Cruces Sande. “Influence of GRK2 levels in hepatic pathophysiology”. Facultad de Ciencias. Universidad Autónoma de Madrid. 27 de abril de 2018
  • Pedro M. Campos Muelas. “Identificacion de peptidos y farmacos inhibidores basados en un nuevo mecanismo de inactivación descubierto para P38 MAPK”. Facultad de Ciencias. Universidad Autónoma de Madrid. 20 de enero de 2016
  • Elisa Lucas Fernández. “GRK2 in the cardiovascular disease continuum: role in hypertension and insulin resistance”. Facultad de Ciencias. Universidad Autónoma de Madrid. 9 de abril de 2015
  • María Jurado Pueyo. “Nuevas funciones celulares de GRKs: Implicaciones fisio-patológicas”. Facultad de Ciencias. Universidad Autónoma de Madrid. 21 de junio de 2010
  • Sandra Peregrín Pedrique. “Interactoma de GRKs: nuevas relaciones funcionales con MAPKs”. Facultad de Ciencias. Universidad Autónoma de Madrid. 20 de Julio de 2005


  • PCT/EP2006/005542 (2010): New phosphorylation site of mitogen-activated protein kinases, modified proteins and applications
  • PCT /ES2011/070774 (2013): p38 inhibitor peptide and uses thereof
  • PCT/ES2012/070762 (2013): Drugs for inhibiting p38 and uses thereof

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