Ofertas de Empleo
FPI, 4 years PhD
Fao impairment in system homeostasis
A four-year Ph.D. contract is offered by the Mitochondria in Pathology group, led by Professor Laura Formentini at the Universidad Autonoma de Madrid (UAM), Centro de Biología Molecular Severo Ochoa (CBMSO), attached to a recently awarded grant funded by the Agencia Estatal de Investigación (contrato FPI). The student will participate in a project aimed at investigating the impact of restrained mitochondrial activity in the development of metabolic disorders and aging.
20/09/2023
Investigador predoctoral (convocatoria FPI de la UAM)/Predoctoral Researcher (UAM FPI call)
Structure, function and regulation of GlyT2 variants associated to hyperekplexia.
Hyperekplexia (OMIM 149400) is a rare sensorimotor syndrome potentially lethal in newborns. It is caused by defects in the inhibitory glycinergic neurotransmission due to mutations in some human genes such as the neuronal glycine transporter GlyT2 (SLC6A5), responsible for supplying glycine to the presynaptic terminal. In this project, the pathogenic mechanisms of GlyT2 mutations found in hyperekplexia patients will be analyzed in terms of the structure of the transporter, its function, intracellular trafficking, interactome, regulation, as well as its consequences in embryonic or adult life. This study can guide future therapeutic approaches we wish to develop.
/Degree in Medicine, Biology, Biochemistry, Biotechnology, Pharmacy or similar. Master completed in the area of Biomedicine. Highly motivated candidates with a good academic record (≥ 8,5) for the completion of the doctorate.
Se ofrece formación multidisciplinar en ambiente dinámico y colaborativo utilizando sistemas de expresión de mutantes en células y cultivos primarios de neuronas para ensayos funcionales de transporte, tráfico intracelular, actividad eléctrica, así como estudios in vivo en pez cebra. Los candidatos deben enviar CV, expediente académico y carta de motivación a la Dra. Beatriz López Corcuera (blopez@cbm.csic.es). / We offer multidisciplinary training in a dynamic and collaborative environment using mutant expression systems in cells and primary neuronal cultures for functional assays of transport, intracellular trafficking, electrical activity, as well as in vivo studies in zebrafish. Candidates must send CV, academic record and motivation letter to Dr. Beatriz López Corcuera
(blopez@cbm.csic.es).
PhD position / Marie-Curie DN Contract (2x)
The role of neonatal enterocytes in gut patterning and development, and their impact on inflammation, and cancer (SurfEx)
Our lab is seeking highly motivated candidates to develop their PhD in the field of Cell Biology and Biomedicine supported by a Marie Curie DN contract (SurfEx-101119504). We are very interested in characterizing the crosstalk between the enterocytes and immune cells during development and pathologies, with particular emphasis In the role that metabolism play during this process. To address these questions, we use in vitro and in vivo techniques, including cutting-edge high-resolution microscopy, engineered organoids, quantitative genomics and proteomics and murine models.
Candidates must not have resided, or carried out main activity, in Spain for more than 12 months in the 36 months immediately before their recruitment date.
Four‐year predoctoral contract OPTI‐CAR‐T
The “Development of the human lymphohematopoietic system” group, led by Marisa Toribio at the Centro de Biología Molecular Severo Ochoa (CBMSO), is looking for a highly motivated candidate to develop her/his thesis in their lab. They offer incorporation via a 4‐year predoctoral contract (FPI programme) linked to the project “Overcoming current challenges of CAR‐T cell immunotherapy for T‐ALL leukemia with optimized CAR constructs (TRuCs) and universal, off‐the‐shelf, effector allogeneic T cells (OPTI‐CAR‐T)” (PID2022‐138880OB‐I00) funded by the Spanish Ministry of Science and Innovation (MICIN) and the State Research Agency (AEI).
• Graduate in biomedical sciences or related areas, with a minimum of 300 ECTS through official university studies, with a minimum of 60 ECTS in master studies.
• Academic record with an average grade over 8 (out of 10).
• Experience in in vivo mouse models, cell culture, immunology and molecular biology will be valued.
• Solid communication skills in English.
Further information:
About the group: http://www.cbm.uam.es/toribiolab
About the CBMSO: http://www.cbm.uam.es
If interested, please send an e‐mail including CV, academic record and 1‐2 reference letters from previous supervisors, no later than September 20th 2023, to:
Marisa Toribio mtoribio@cbm.csic.es
Investigador Predoctoral (convocatoria FPI de la UAM)/ predoctoral Researcher (UAM FPI call)
Alteraciones del ciclo celular y patrones de división de las células tumorales de mama en condiciones de estrés / Cell cycle alterations and division patterns
of breast tumor cells under stress conditions
Titulado Superior
Peptide Vaccines, Antiviral Strategies And Viral Immune Evasion Mechanisms. Biotherapeutic Applications
Solicitud de contrato INVESTIGADOR PREDOCTORAL
Redes de señalización de receptores acoplados a proteínas G: nuevas vías de
señalización e implicaciones fisopatológicas de los interactomas de Gq y GRK2.
Las líneas de investigación estarán orientadas al estudio de redes de señ alizació n de GPCR, GRK2 y Gq en la homeostasis y comunicació n celular y de sus alteraciones en patologías inflamatorias, cardiovasculares y tumorales https://www.cbm.uam.es/cribas http://www.cbm.uam.es/fmayor
