{"id":288088,"date":"2024-12-09T14:10:51","date_gmt":"2024-12-09T13:10:51","guid":{"rendered":"https:\/\/www.cbm.uam.es\/index.php\/job\/centro-de-biologia-molecular-severo-ochoa-cbm-madrid-full-time-es-estructura-funcion-y-regulacion-de-variantes-de-glyt2-asociadas-a-hiperplexia-structure-function-and-regulation-of-glyt2-variant\/"},"modified":"2025-03-16T00:14:08","modified_gmt":"2025-03-15T23:14:08","slug":"centro-de-biologia-molecular-severo-ochoa-cbm-madrid-full-time-es-estructura-funcion-y-regulacion-de-variantes-de-glyt2-asociadas-a-hiperplexia-structure-function-and-regulation-of-glyt2-variant","status":"expired","type":"job_listing","link":"https:\/\/www.cbm.uam.es\/?post_type=job_listing&p=288088","title":{"rendered":"PhD candidate search: Structure, function and regulation of GlyT2 variants associated to hyperplexia \/ Estructura, funci\u00f3n y regulaci\u00f3n de variantes de GlyT2 asociadas a hiperplexia \/\/"},"content":{"rendered":"<p><strong>PROYECTO\/ PROJECT:<\/strong><\/p>\n<p>La hiperplexia (OMIM 149400) es un s\u00edndrome sensoriomotor poco frecuente y potencialmente letal en reci\u00e9n nacidos. Est\u00e1 causada por defectos en la neurotransmisi\u00f3n glicin\u00e9rgica inhibidora debido a mutaciones en algunos genes humanos como el transportador neuronal de glicina GlyT2 (<em>SLC6A5<\/em>), encargado de suministrar glicina al terminal presin\u00e1ptico. En este proyecto se analizar\u00e1n los mecanismos patog\u00e9nicos de las mutaciones de GlyT2 encontradas en pacientes con hiperplexia en cuanto a la estructura del transportador, su funci\u00f3n, tr\u00e1fico intracelular, interactoma, regulaci\u00f3n, as\u00ed como las consecuencias en la vida embrionaria o adulta. Este estudio puede orientar futuras aproximaciones terap\u00e9uticas que deseamos desarrollar.<\/p>\n<p>\/\/<\/p>\n<p>Hyperekplexia (OMIM 149400) is a rare sensorimotor syndrome potentially lethal in newborns. It is caused by defects in the inhibitory glycinergic neurotransmission due to mutations in some human genes such as the neuronal glycine transporter GlyT2 (<em>SLC6A5<\/em>), responsible for supplying glycine to the presynaptic terminal. In this project, the pathogenic mechanisms of GlyT2 mutations found in hyperekplexia patients will be analyzed in terms of the structure of the transporter, function, intracellular trafficking, interactome, regulation, as well as the consequences in embryonic or adult life. This study can guide future therapeutic approaches we wish to develop.<\/p>\n<p><strong>REQUERIMIENTOS\/REQUIREMENTS:<\/strong><\/p>\n<ul>\n<li>Grado en Medicina, Biolog\u00eda, Biotecnolog\u00eda, Farmacia, o relacionado.<\/li>\n<li>M\u00e1ster finalizado en el \u00e1rea de Biomedicina.<\/li>\n<li>Candidatos altamente motivados y con un buen expediente acad\u00e9mico (\u2265 8,5) para la realizaci\u00f3n del doctorado.<\/li>\n<\/ul>\n<p>\/\/<\/p>\n<ul>\n<li>Degree in Medicine, Biology, Biochemistry, Biotechnology, Pharmacy or similar.<\/li>\n<li>Master completed in the area of Biomedicine.<\/li>\n<li>Highly motivated candidates with a good academic record (\u2265 8,5) for the completion of the doctorate.<\/li>\n<\/ul>\n<p><strong>CONTACT\/CONTACTO:<\/strong><\/p>\n<p>Enviar CV y expediente acad\u00e9mico a: blopez@cbm.csic.es con antelaci\u00f3n al cierre de la convocatoria FPU 2025 \/\/ Send CV and academic records to:\u00a0 blopez@cbm.csic.es, before the deadline to apply for FPU contracts 2025.<\/p>\n<p><strong>DURATION\/DURACI\u00d3N:<\/strong><\/p>\n<p>4 a\u00f1os \/ 4 years<\/p>\n<p><strong>OTRA INFORMACI\u00d3N\/OTHER INFORMATION:<\/strong><\/p>\n<p>Se ofrece formaci\u00f3n multidisciplinar en ambiente din\u00e1mico y colaborativo utilizando sistemas de expresi\u00f3n de mutantes en c\u00e9lulas y cultivos primarios de neuronas para ensayos funcionales de transporte, tr\u00e1fico intracelular, actividad el\u00e9ctrica, as\u00ed como estudios in vivo en ratones y pez cebra. \/\/ We offer multidisciplinary training in a dynamic and collaborative environment using mutant expression in cells and primary neuronal cultures for functional assays of transport, intracellular trafficking, electrical activity, as well as in vivo studies in mice and zebrafish.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":41,"featured_media":277775,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_promoted":"","_job_location":"Madrid","_application":"blopez@cbm.csic.es","_company_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","_company_website":"https:\/\/www.cbm.uam.es\/blopez","_company_tagline":"Decoding life","_company_twitter":"@cbm_csic_uam","_company_video":"","_filled":1,"_featured":0,"_remote_position":0,"_job_salary":"","_job_salary_currency":"","_job_salary_unit":""},"job-categories":[110],"job-types":[73],"class_list":{"0":"post-288088","1":"job_listing","2":"type-job_listing","3":"status-expired","4":"has-post-thumbnail","5":"hentry","7":"job-type-full-time","8":"job_position_filled"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PhD candidate search: Structure, function and regulation of GlyT2 variants associated to hyperplexia \/ Estructura, funci\u00f3n y regulaci\u00f3n de variantes de GlyT2 asociadas a hiperplexia \/\/ - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/?post_type=job_listing&p=288088\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD candidate search: Structure, function and regulation of GlyT2 variants associated to hyperplexia \/ Estructura, funci\u00f3n y regulaci\u00f3n de variantes de GlyT2 asociadas a hiperplexia \/\/ - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"PROYECTO\/ PROJECT: La hiperplexia (OMIM 149400) es un s\u00edndrome sensoriomotor poco frecuente y potencialmente letal en reci\u00e9n nacidos. 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