We are offering a predoctoral position in our group to study the molecular mechanisms driving aortic diseases, particularly familial forms of thoracic aortic aneurysm and dissection (TAAD). Our research focuses on identifying key mediators involved in the pathogenesis of Marfan and Loeys-Dietz syndromes. We use advanced imaging, omics technologies, biochemical and genetic approaches in both mouse models and patient samples to discover risk biomarkers and therapeutic targets.<\/p>\n
We are seeking a highly motivated individual interested in starting a scientific career and pursuing a PhD within our team. Applicants must have completed a Master\u2019s degree in Biomedicine or a related field by September 2025 at the latest and have a Grade Point Average above 8\/10 in their academic record.<\/p>\n
The ideal candidate will demonstrate initiative and creativity in formulating hypotheses and solving problems, as well as a proactive attitude toward scientific and experimental challenges. We value openness to continuous learning, strong organizational and communication skills, self-criticism, scientific rigor, and a solid work ethic.<\/p>\n
We offer the opportunity to join our team through a predoctoral contract linked to the project aimed at advancing the understanding and treatment of aortic aneurysms in Marfan and Loeys-Dietz syndromes.<\/p>\n
<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Yunes-Leites PS, et al. Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension. PLoS Biol. 2025<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 G\u00f3mez-Del Arco P, et al. The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ru\u00edz-Rodr\u00edguez MJ, et al. Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation. EMBO Mol Med. 2024<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Toral M, et al. The Nitric Oxide Signalling Pathway in Aortic Aneurysm and Dissection. Br J Pharmacol. 2021<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 de la Fuente-Alonso A, et al. Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO. Nat Commun. 2021<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alfranca A, et al. New Methods for Disease Modeling Using Lentiviral Vectors. Trends Mol Med. 2018<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Villahoz S, et al. Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Nat Commun. 2018<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 de C\u00e1rcer G, et al. Plk regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat Med. 2017<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Oller J, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017<\/p>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 G\u00f3mez-Del Arco P, et al. The Chromatin Remodeling Complex Chd4\/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016<\/p>\n
<\/p>\n
More information about our group\u2019s research activities is available on our website:
\nhttps:\/\/www.cbm.uam.es\/jmredondo<\/p>\n","protected":false},"author":60,"featured_media":289724,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_promoted":"","_job_location":"Madrid","_application":"jmredondo@cbm.csic.es","_company_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","_company_website":"http:\/\/cbm.uam.es","_company_tagline":"https:\/\/www.cbm.uam.es\/jmredondo","_company_twitter":"","_company_video":"","_filled":0,"_featured":0,"_remote_position":0,"_job_salary":"","_job_salary_currency":"","_job_salary_unit":""},"job-categories":[104],"job-types":[73],"class_list":["post-291006","job_listing","type-job_listing","status-expired","has-post-thumbnail","hentry","job-type-full-time"],"yoast_head":"\n