{"id":278607,"date":"2024-05-27T14:00:42","date_gmt":"2024-05-27T12:00:42","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=278607"},"modified":"2024-08-26T15:14:53","modified_gmt":"2024-08-26T13:14:53","slug":"tissue-and-organ-homeostasis","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/","title":{"rendered":"Tissue and organ homeostasis"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; background_image=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/iStock-640020840jpeg-scaled.jpg&#8221; background_position=&#8221;bottom_center&#8221; background_vertical_offset=&#8221;32%&#8221; min_height=&#8221;352px&#8221; height=&#8221;294px&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; 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custom_margin=&#8221;0px||10px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Scientific program<\/p>\n<p>[\/et_pb_text][et_pb_heading title=&#8221;Tissue and organ homeostasis&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;Montserrat||||||||&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;43px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;157px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_size=&#8221;custom&#8221; background_image_height=&#8221;84%&#8221; background_position=&#8221;bottom_right&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,2_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(204,209,209,0.18)&#8221; custom_padding=&#8221;15px|15px|15px|15px|true|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;Director&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x57;||divi||400&#8243; icon_color=&#8221;#13B5BD&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;25px&#8221; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#34609B&#8221; image_icon_custom_margin=&#8221;-3px|-1px|||false|false&#8221; image_icon_custom_padding=&#8221;|0px|||false|false&#8221; custom_margin=&#8221;|-1px||0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Fernando Mart\u00edn Belmonte&#8221; image=&#8221;\/imgs\/788.jpg&#8221; image_icon_width=&#8221;200px&#8221; module_class=&#8221;roundedImg&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;Montserrat|600|||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#008C93&#8243; header_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-27px||||false|false&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"text-align: center;\">Lab 120<br \/>Ext. 4616<br \/>fmartin(at)cbm.csic.es<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; text_line_height=&#8221;1.9em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Multicellular organisms are composed of a large number of cells (about 30 trillion in humans), which are organized in tissues and organs, kept together by tissue-specific extracellular matrix. \u00a0Each tissue has a\u00a0highly specialized function, acquired during development through a network of regulatory mechanisms. These mechanisms also establish local and systemic signals that ensure exquisite tissues\u2019 coordination in response to the physiological needs of the organisms and their interaction with the surrounding environment.\u00a0The Tissue and Organ Homeostasis Program gathers together three Units interested in understanding how tissue and organ organization is achieved, maintained and adapted in response to damage, diseases or physiological aging of the individuals. The different ongoing research projects address these fundamental issues at the molecular, subcellular, cellular and systemic level using multidisciplinary approaches (molecular, cellular and system biology, biochemistry,\u00a0in vivo\u00a0imaging, experimental embryology and mathematical modeling) and a variety of\u00a0in vitro\u00a0(i.e. cell lines, pluripotent cells, primary cell and tissue cultures, organoids) and\u00a0in vivo\u00a0experimental models (i.e.\u00a0Drosophila, zebrafish, rodents). \u00a0Through joint, national and international collaborative research, the program seeks to identify those mechanisms that could be exploited to prevent and treat diseases, induce tissues\u2019 regeneration and improve the quality of life of aging individuals.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; da_disable_devices=&#8221;off|off|off&#8221; 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