{"id":279010,"date":"2024-07-31T09:00:19","date_gmt":"2024-07-31T07:00:19","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=279010"},"modified":"2025-01-02T00:19:35","modified_gmt":"2025-01-01T23:19:35","slug":"adult-neurogenesis-and-neurodegenerative-diseases","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/physiological-and-pathological-processes\/molecular-neuropathology\/adult-neurogenesis-and-neurodegenerative-diseases\/","title":{"rendered":"Adult neurogenesis and neurodegenerative diseases"},"content":{"rendered":"

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Scientific Program<\/p>\n

[\/et_pb_text][et_pb_heading title=”Physiological and pathological processes” _builder_version=”4.25.0″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNITS IN THIS PROGRAM
<\/span><\/h4>\n
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Molecular neuropathology<\/a><\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Metabolic and signaling networks in disease<\/a><\/span><\/h6>\n

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\"\"<\/span><\/a>\"\"<\/span><\/a>\"\"<\/span><\/a>\"\"<\/span><\/a><\/p>\n

External group website<\/a>
ORCID<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#investiga” button_text=”Research” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#personal” button_text=”Group members” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” custom_padding=”|44px||44px|false|true” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#publica” button_text=”Publications” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”20px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”resumen” module_id=”resumen” module_class=”resumen” _builder_version=”4.27.2″ _module_preset=”default” text_font_size=”15px” text_line_height=”1.8em” background_color=”#f1f8fe” custom_margin=”||33px|||” custom_padding=”20px|20px|20px|20px|true|false” border_width_top=”1px” border_color_top=”#008C93″ border_width_bottom=”1px” border_color_bottom=”#008C93″ global_colors_info=”{}”]<\/p>\n

Certain regions of the mammalian brain continue growing new neurons throughout life. This process, named adult neurogenesis, confers an extraordinary degree of plasticity to the central nervous system. The LlorensLab is focused on understanding the regulation of adult neurogenesis in distinct mammalian species. Our final goal is to exploit the potential of adult neurogenesis to counteract the consequences of physiological and pathological aging.<\/p>\n

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Our research group investigates the mechanisms that control adult hippocampal neurogenesis, both under physiological and pathological conditions. We perform in vivo and in vitro studies animal models of different diseases, and also use human brain samples. In particular, we are interested in determining the therapeutic potential of increasing adult hippocampal neurogenesis for the treatment of neurodegenerative diseases such as Alzheimer\u00b4s disease (AD), Huntington\u00b4s disease, Parkinson\u00b4s disease, or ALS, and psychiatric conditions. The hippocampus plays a pivotal role in learning and memory. Furthermore, a unique feature of this structure is the existence of adult neurogenesis. The process of adult hippocampal neurogenesis encompasses the birth and functional integration of newborn neurons throughout lifetime. Adult hippocampal circuit confers and extraordinary degree of plasticity to the circuit. Thus, we work to develop strategies capable of increasing the functionality of newborn neurons.<\/p>\n

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Impact of neurodegenerative diseases on human adult hippocampal neurogenesis<\/h3>\n

J. TERREROS-RONCAL et al.<\/p>\n

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Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease<\/h3>\n

Elena P. Moreno-Jim\u00e9nez et al<\/p>\n

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Unraveling human adult hippocampal neurogenesis<\/h3>\n

Miguel Flor-Garc\u00eda et al.<\/p>\n

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Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis<\/h3>\n

Noem\u00ed Pallas\u2010Bazarra et al.<\/p>\n

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Cargando publicaciones…<\/div>\n