{"id":279941,"date":"2024-09-20T12:06:49","date_gmt":"2024-09-20T10:06:49","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=279941"},"modified":"2025-07-07T16:35:32","modified_gmt":"2025-07-07T14:35:32","slug":"electron-microscopy","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/","title":{"rendered":"Electron microscopy"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.25.0″ _module_preset=”default” background_color=”#34609B” background_image=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/Captura-de-Pantalla-2024-06-14-a-las-14.59.19-scaled.jpg” background_position=”bottom_center” background_vertical_offset=”22%” min_height=”352px” height=”294px” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”2_5,3_5″ use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” custom_margin=”61px||||false|false” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(52,96,155,0.83)” custom_padding=”50px||50px|50px|false|false” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_margin=”0px||10px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

Scientific facilities<\/p>\n

[\/et_pb_text][et_pb_heading title=”Electron microscopy” _builder_version=”4.25.0″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” title_line_height=”1.1em” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”30px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(204,209,209,0.18)” custom_padding=”15px|15px|15px|15px|true|true” global_colors_info=”{}”][et_pb_blurb title=”Facility Head” use_icon=”on” font_icon=”W||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”25px” _builder_version=”4.25.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#34609B” image_icon_custom_margin=”-3px|-1px|||false|false” image_icon_custom_padding=”|0px|||false|false” custom_margin=”|-1px||0px|false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Martin Christoph Sachse” image=”https:\/\/www.cbm.uam.es\/imgs\/6062.jpg” image_icon_width=”200px” module_class=”roundedImg” _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”center” header_font_size=”14px” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Contact details” use_icon=”on” font_icon=”W||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”25px” _builder_version=”4.25.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#34609B” body_font_size=”11px” body_line_height=”1.6em” image_icon_custom_margin=”-3px|-1px|||false|false” image_icon_custom_padding=”|0px|||false|false” custom_margin=”|-1px||0px|false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”91 196 45 32″ use_icon=”on” font_icon=”||fa||900″ icon_color=”#008C93″ icon_placement=”left” image_icon_width=”16px” _builder_version=”4.27.4″ _module_preset=”default” header_font_size=”14px” image_icon_custom_margin=”|-5px||50px|false|false” image_icon_custom_padding=”||||false|false” custom_margin=”-11px||5px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”sme (at) cbm.csic.es” use_icon=”on” font_icon=”||divi||400″ icon_color=”#008C93″ icon_placement=”left” image_icon_width=”16px” _builder_version=”4.25.0″ _module_preset=”default” header_font_size=”14px” image_icon_custom_margin=”|-5px||50px|false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Fees” use_icon=”on” font_icon=”W||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”25px” _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” header_text_color=”#34609B” body_font_size=”11px” body_line_height=”1.6em” image_icon_custom_margin=”-3px|-1px|||false|false” image_icon_custom_padding=”|0px|||false|false” custom_margin=”|-1px||0px|false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_icon font_icon=”||fa||400″ icon_color=”#13B5BD” icon_width=”24px” url=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/05\/Tarifas_SME_2025.pdf” url_new_window=”on” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”-21px|||-167px|false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][\/et_pb_icon][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

The Electron microscopy facility provides scientific and technical support to research groups, both internal and external to the CBM, interested in using transmission electron microscopy for ultrastructural and immunocytochemical analysis of biological samples.<\/p>\n

We can study macromolecular complexes, viruses, bacteria, eukaryotic cells and tissues. Available methods include conventional room temperature processing techniques and cryo-techniques such as cryosubstitution, cryoultramicrotomy and cryofracture.<\/p>\n

[\/et_pb_text][et_pb_accordion open_toggle_text_color=”#34609B” closed_toggle_text_color=”#34609B” closed_toggle_background_color=”rgba(175,218,249,0.39)” toggle_icon=”G||divi||400″ icon_color=”#008C93″ _builder_version=”4.27.4″ _module_preset=”default” animation_style=”slide” animation_direction=”bottom” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_spread=”-10px” global_colors_info=”{}” sticky_enabled=”0″][et_pb_accordion_item title=”Don\u00b4t even think of editing this!” open=”on” _builder_version=”4.27.4″ _module_preset=”default” transform_scale=”-2%|-2%” custom_css_main_element=”display: none;” border_width_all=”0px” border_color_all=”RGBA(255,255,255,0)” border_style_all=”none” global_colors_info=”{}”]<\/p>\n

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– Transmission electron microscope JEM1010 (Jeol,1992)
– Thermionic emission gun: tungsten filament.
– Accelerating voltage up to 100kV.
– Digital camera under CMOS column TemCam F416 (TVIPS)<\/p>\n

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– JEM1400 Flash transmission electron microscope (Jeol, 2017)
– Thermionic emission gun: LaB6 filament.
– Accelerating voltage up to 120kV.
– OneView fast readout CMOS digital camera under column (Gatan).<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Transmission electron microscopes” toggle_icon=”||fa||900″ use_icon_font_size=”on” icon_font_size=”22px” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

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Transmission electron microscope JEM1010 (Jeol,1992)\u00a0
– Thermionic emission gun: tungsten filament.
– Accelerating voltage up to 100kV.
– Digital camera under CMOS column TemCam F416 (TVIPS)<\/p>\n

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\u00a0JEM1400 Flash transmission electron microscope (Jeol, 2017) Fot2
– Thermionic emission gun: LaB6 filament.
– Accelerating voltage up to 120kV.
– OneView fast readout CMOS digital camera under column (Gatan).<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Cold sample processing equipment” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”20px” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

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Cryofixation by immersion in cryogenic liquid (“plunge freezing” ), KF80 equipment (Reichert-Jung, Leica, 1992)
– Vitrification of particulate samples (macromolecules, viruses…) adsorbed on grids in liquid ethane.
– Cryofixation of chemically fixed and cryoprotected cells or tissues for processing by cryosubstitution or cryofracturing.<\/p>\n

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High pressure cryofixation (HPF), LEICA EM ICE (2023).<\/p>\n

– Vitrification of cells, tissues and small organisms under native conditions for processing by cryosubstitution or cryofracturing.<\/p>\n

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Automatic cryosubstitution, LEICA EM AFS2 (2023).
– Dehydration at low temperatures, -90 \u00b0C, -80 \u00b0C, cryoinclusion in Lowicryl resins and polymerization with UV light at low temperatures.<\/p>\n

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Cryofracture\/ Freeze-etching, BAF060 equipment (Leica, 2007)
– Cryofracture of cells and tissues and obtaining metallic replicas of the fractured surface.
– Pt\/C rotary shading of nucleic acids and viruses.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Ultramicrotomes” toggle_icon=”||fa||900″ use_icon_font_size=”on” icon_font_size=”20px” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” open=”off” sticky_enabled=”0″]<\/p>\n

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Ultramicrotome ULTRACUT E (Reichert-Jung, Leica)
– to obtain semithin, 1\u00b5m<\/span>, and ultrathin, 50nm – 90nm sections at room temperature of samples embedded in resins.<\/p>\n

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Ultramicrotome with cryo camera, UCT (Leica)
– For semithin, 1\u00b5m<\/span>, and ultrathin, 50nm – 90nm sections at room temperature of samples included in resins.
– To obtain cryosections at low temperature, – 80 \u00baC to -120\u00baC for immunolabeling on thawed sections (Tokuyasu technique).<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Leica EM AC600 Evaporator (2023)” toggle_icon=”||fa||900″ use_icon_font_size=”on” icon_font_size=”20px” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” open=”off” sticky_enabled=”0″]<\/p>\n

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– Evaporation of a carbon film with defined thickness on grids.
– Ionization of grids for negative staining with “Glow discharge”.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Techniques” toggle_icon=”||fa||900″ use_icon_font_size=”on” icon_font_size=”20px” _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

– Negative staining of macromolecular complexes and viruses. Photo technique 1
– Analysis of nanoparticles.
– Conventional embedding of biological samples in resins and ultramicrotomy. Technical photo 2
– Cryofixation by immersion in liquid ethane and high pressure.
– Cryosubstitution and inclusion at low temperature. Technical photo 3
– Electron immunomicroscopy with colloidal gold conjugates in resin sections. Technical photo 4
– Electron immunomicroscopy with colloidal gold conjugates in cryosections (Tokuyasu technique). Technical photo 5
– Cryofracture, cryosectioning and obtaining metal replicas. Technical photo 6
– Electron microscopy of nucleic acids. Technical photo 7
– Correlative optical-electron microscopy (CLEM).<\/p>\n

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Staff” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.2″ _module_preset=”default” max_width=”2560px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_code _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Milagros Guerra Rodr\u00edguez\" image=\"\/imgs\/170.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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mguerra(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Tania Matamoros Grande\" image=\"\/imgs\/361.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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tmatamoros(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Raquel Losada de Paz\" image=\"\/imgs\/5707.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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rlosada(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Martin Christoph Sachse \" image=\"\/imgs\/6062.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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Scientific facilitiesThe Electron microscopy facility provides scientific and technical support to research groups, both internal and external to the CBM, interested in using transmission electron microscopy for ultrastructural and immunocytochemical […]<\/p>\n","protected":false},"author":59,"featured_media":0,"parent":209,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-279941","page","type-page","status-publish","hentry"],"yoast_head":"\nElectron microscopy - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Electron microscopy - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"Scientific facilitiesThe Electron microscopy facility provides scientific and technical support to research groups, both internal and external to the CBM, interested in using transmission electron microscopy for ultrastructural and immunocytochemical […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-07T14:35:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/05\/1-TEM_JEM1010-300x279.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/\",\"url\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/\",\"name\":\"Electron microscopy - Centro de Biolog\u00eda Molecular Severo Ochoa\",\"isPartOf\":{\"@id\":\"https:\/\/www.cbm.uam.es\/?lang=es\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/05\/1-TEM_JEM1010-300x279.jpg\",\"datePublished\":\"2024-09-20T10:06:49+00:00\",\"dateModified\":\"2025-07-07T14:35:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/#primaryimage\",\"url\":\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/05\/1-TEM_JEM1010-scaled.jpg\",\"contentUrl\":\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/05\/1-TEM_JEM1010-scaled.jpg\",\"width\":2560,\"height\":2384},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/electron-microscopy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/www.cbm.uam.es\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Facilities\",\"item\":\"https:\/\/www.cbm.uam.es\/index.php\/facilities\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Electron microscopy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cbm.uam.es\/?lang=es\/#website\",\"url\":\"https:\/\/www.cbm.uam.es\/?lang=es\/\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"description\":\"Official website of the CBM, CSIC - UAM. 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