{"id":280214,"date":"2024-07-31T09:01:40","date_gmt":"2024-07-31T07:01:40","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=280214"},"modified":"2024-10-28T12:32:45","modified_gmt":"2024-10-28T11:32:45","slug":"morphogenesis-and-neurodegeneration-of-the-vertebrate-central-nervous-system","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-architecture-and-organogenesis\/morphogenesis-and-neurodegeneration-of-the-vertebrate-central-nervous-system\/","title":{"rendered":"Morphogenesis and neurodegeneration of the vertebrate Central Nervous System"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.0″ _module_preset=”default” background_color=”#34609B” background_image=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/istockphoto-504793828-2048x2048banner.jpg” background_position=”bottom_center” background_vertical_offset=”32%” min_height=”352px” height=”294px” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”2_5,3_5″ use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” custom_margin=”61px||||false|false” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(52,96,155,0.83)” custom_padding=”50px||50px|50px|false|false” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_margin=”0px||10px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

Scientific Program<\/p>\n

[\/et_pb_text][et_pb_heading title=”Tissue and organ homeostasis” _builder_version=”4.25.0″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNITS IN THIS PROGRAM
\n<\/span><\/h4>\n
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\nCell architecture and organogenesis<\/a><\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cell-cell communication and inflammation<\/a><\/span><\/h6>\n

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\nORCID<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#investiga” button_text=”Research” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#personal” button_text=”Group members” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” custom_padding=”|44px||44px|false|true” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#publica” button_text=”Publications” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”20px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”resumen” module_id=”resumen” module_class=”resumen” _builder_version=”4.25.0″ _module_preset=”default” text_font_size=”15px” text_line_height=”1.8em” background_color=”#f1f8fe” custom_padding=”20px|20px|20px|20px|true|false” border_width_top=”1px” border_color_top=”#008C93″ border_width_bottom=”1px” border_color_bottom=”#008C93″ global_colors_info=”{}”]<\/p>\n

Why do some defects arise during the development of our brain, and why does our brain age or degenerate? Answering these key questions drives our research. These answers are crucial for eventually preventing or treating the numerous diseases that affect the nervous system, thereby avoiding their serious socio-economic consequence. We address these questions by combining different experimental models (zebrafish, mouse, and human organoids) with cellular and molecular biology approaches.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/Imagen3-Grupo-P.-Bovolenta.jpg” title_text=” ” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Research” module_id=”investiga” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

The brain and other parts of the central nervous system (CNS), such as the retina, develop over a long period of time before reaching their final organization. Such a long period enables millions of neural cells to progressively acquire their specific identity and to progressively establish a precise network of functional connections among the generated cell types. Reaching such an elaborated organization is fundamental for our daily life and well-being. As we age, the brain again undergoes progressive changes but unfortunately \u201cin the reverse direction\u201d, making us less proficient. When these changes are drastic, as it happens in people suffering from Alzheimer\u2019 disease or in individuals who becomes blind because their \u201cphotoreceptors\u201d degenerate, performing even simple duties or relating to the immediate surroundings become impossible. Knowing how to have and preserve a healthy brain thus falls in between the comprehension of its development and the identification of the causes of its ageing. Our laboratory divides its research efforts between these two extremes. On one side we investigate a) how the visual system forms; on the other, b) we search the molecular causes underlying the brain alterations occurring in aging and\/or Alzheimer \u2018disease.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/2024-05-08-Grupo-Paola-Bovolenta-02-1000px.jpg” title_text=”2024-05-08 Grupo Paola Bovolenta 02-1000px” _builder_version=”4.27.2″ _module_preset=”default” custom_margin=”60px||||false|false” custom_padding=”|||27px||” animation_style=”zoom” hover_enabled=”0″ border_width_all=”3px” border_color_all=”#13B5BD” box_shadow_style=”preset3″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

a) For over twenty years, our team has contributed to identify and study the molecular building blocks that coordinate the development of the vertebrate visual system. Building on this experience, we are now investigating how the retinal pigmented epithelium (RPE) forms and contributes to the overall architecture of the eye. The RPE consists of a monolayer of cells, positioned at the back of the neural retina. This tissue has the critical function of protecting, nourishing and cooperating with the light sensing cells of the retina: the photoreceptors. The cells of the RPE are initially neuroepithelial as those of the neural retina but soon transform in a cuboidal\/squamous pigmented layer (Figure 1). The events underlying this transformation are still poorly understood. Using the zebrafish and chick embryos as models, we are studying the cellular and molecular aspects of this transformation and are further asking whether this transformation is necessary for the acquisition of the final cup-shape that the vertebrate eye has. In other words, we want to know what happens to the eye if the RPE does not develop correctly. As an extension of this question, we are also asking how the entire visual system adapts to the abnormal development of one of its parts. For example, what happens to the eye if the thalamic visual structures do not form in an appropriate manner?<\/p>\n

b) When the brain ages, the number of functional connections among neurons decreases and the brain assume a state of low but chronic \u201cinflammation\u201d. These changes are exacerbated in neurodegenerative diseases such as Alzheimer\u2019s Disease (AD), in which there is also an accumulation of typical \u201camyloid plaques\u201d (Figure 2). From a molecular point of view, loss of connections, inflammation and amyloid plaque formation have a commonality: the activity of the metalloprotease ADAM10. We have recently shown that a small secreted protein, known as Secreted Frizzled Related Protein 1 (SFRP1), acts as an endogenous inhibitor of ADAM10. Based on this observation, we hypothesized that abnormally upregulated SFRP1 levels in the brain of AD patients could impair ADAM10 activity and be a common trait of AD. Our work has validated this hypothesis, demonstrating that SFRP1 contributes to AD pathogenesis, whereas neutralization of its activity in a mouse model prevents the progression of the disease and the loss of memory present in AD (or in aging). Based on this exciting result and taking advantage of different transgenic mouse models that we have generated, we are now investigating the direct implication of Sfrp1 in the loss of brain connections and in the inflammatory events that take place in AD and aging. We are further exploring the potential of SFRP1 neutralization as a therapeutic strategy against AD.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.04)” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Group members” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.0″ _module_preset=”default” max_width=”2560px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_code _builder_version=”4.25.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"M\u00aa Jes\u00fas Mart\u00edn Bermejo\" image=\"\/imgs\/206.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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SFRP1 modulates astrocyte\u2010to\u2010microglia crosstalk in acute and chronic neuroinflammation<\/h3>\n

Javier Rueda\u2010Carrasco et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/2-Grupo-P.-Bovolenta.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” link_option_url=”https:\/\/www.nature.com\/articles\/ncomms5272″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle<\/h3>\n

Marcos Juli\u00e1n Cardozo et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/3-Grupo-P.-Bovolenta.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/31308530\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis<\/h3>\n

Pilar Esteve et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/4-Grupo-P.-Bovolenta.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/34545806\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis<\/h3>\n

Tania Moreno-M\u00e1rmol et al.<\/p>\n

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