{"id":280547,"date":"2024-07-31T09:01:37","date_gmt":"2024-07-31T07:01:37","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=280547"},"modified":"2025-01-01T23:54:12","modified_gmt":"2025-01-01T22:54:12","slug":"vascular-inflammation-and-autophagy","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/physiological-and-pathological-processes\/metabolic-and-signaling-networks-in-disease\/vascular-inflammation-and-autophagy\/","title":{"rendered":"Vascular inflammation and autophagy"},"content":{"rendered":"

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Scientific Program<\/p>\n

[\/et_pb_text][et_pb_heading title=”Physiological and pathological processes” _builder_version=”4.25.2″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNITS IN THIS PROGRAM
\n<\/span><\/h4>\n
\n

\nMolecular neuropathology<\/a><\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Metabolic and signaling networks in disease<\/a><\/span><\/h6>\n

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\"\"<\/a>
\nORCID<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#investiga” button_text=”Research” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#personal” button_text=”Group members” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” custom_padding=”|44px||44px|false|true” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#publica” button_text=”Publications” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”20px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”resumen” module_id=”resumen” module_class=”resumen” _builder_version=”4.25.2″ _module_preset=”default” text_font_size=”15px” text_line_height=”1.8em” background_color=”#f1f8fe” custom_padding=”20px|20px|20px|20px|true|false” border_width_top=”1px” border_color_top=”#008C93″ border_width_bottom=”1px” border_color_bottom=”#008C93″ global_colors_info=”{}”]<\/p>\n

Our lab is interested in exploring the interplay between immune cells and the vascular system during physiological and pathological inflammation with the aim of identifying new therapeutic targets to modulate inflammatory diseases. To address our research questions, we use a variety of in vitro and in vivo techniques, including cutting-edge high-resolution microscopy, quantitative proteomics and murine models of inflammation.<\/p>\n

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Inflammation is at the basis of a plethora of diseases with very different aetiological origins. Although this immune reaction plays a paramount role during host survival and tissue repair, inflammation must be tightly regulated to avoid excessive tissue damage and the instigation of inflammatory diseases. For instance, uncontrolled recruitment of immune cells from blood vessels to injured tissues, as well as dysregulated vascular leakage, can lead to the development of numerous pathologies, including highly prevalent cardiovascular, metabolic and infectious conditions as well as tumour progression. Therefore, understanding the mechanisms through which the vasculature becomes dysfunctional during pathological inflammation is an area of extremely forefront research interest.<\/p>\n

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In recent years, autophagy, a metabolic, cytoplasmic quality control and general homeostatic process, has emerged as a central regulator of immune functions. So far, most of this evidence derives from immune cell-autonomous control of inflammation, with autophagy regulating the survival, differentiation, polarization and inflammatory mediator generation of diverse immune cell subsets. Crucially, our group has demonstrated that autophagy processes in endothelial cells, the portal governing the entry of leukocytes and macromolecules into tissues, are essential to limit neutrophil tissue recruitment during acute inflammation and associated tissue damage. However, the molecular mechanisms and nature of the autophagy processes regulating this phenomenon is still unknown. Hence, the main goal of our emerging laboratory is to decipher the molecular mechanisms through which endothelial cell autophagy pathways shape the inflammatory response with the aim of identifying new therapeutic approaches for the regulation of inflammatory disorders. Collectively, we aim to explore the initiating factors, molecular characteristics and pathophysiological relevance of endothelial autophagy processes during acute and chronic inflammation as well as ageing-associated pathologies.<\/p>\n

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nreglero(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Dafne Garc\u00eda Mateos\" image=\"\/imgs\/5538.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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gmarcos(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Irene Carriles Moar\" image=\"\/imgs\/5987.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation<\/h3>\n

Natalia Reglero-Real et al.<\/p>\n

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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage<\/h3>\n

Anna Barkaway et al.<\/p>\n

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Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation<\/h3>\n

Natalia Reglero-Real et al.<\/p>\n

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Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells<\/h3>\n

Natalia Reglero-Real et al.<\/p>\n

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