{"id":280567,"date":"2024-07-31T09:00:22","date_gmt":"2024-07-31T07:00:22","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=280567"},"modified":"2024-10-28T10:29:56","modified_gmt":"2024-10-28T09:29:56","slug":"descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es","title":{"rendered":"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; background_image=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/iStock-1833377669small-scaled.jpg&#8221; background_position=&#8221;bottom_center&#8221; background_vertical_offset=&#8221;32%&#8221; min_height=&#8221;352px&#8221; height=&#8221;294px&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; custom_margin=&#8221;61px||||false|false&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(52,96,155,0.83)&#8221; custom_padding=&#8221;50px||50px|50px|false|false&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;0px||10px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Programa Cient\u00edfico<\/p>\n<p>[\/et_pb_text][et_pb_heading title=&#8221;Interacciones con el entorno&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;Montserrat||||||||&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;43px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;157px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4 style=\"text-align: center;\"><span style=\"color: #13b5bd;\">UNIDADES EN ESTE PROGRAMA <\/span><\/h4>\n<hr>\n<h6 style=\"text-align: center;\"><span style=\"color: #13b5bd;\"><a href=\"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/?lang=es\"> Microorganismos en la salud y el bienestar<\/a><\/span> <span style=\"color: #abb8c3;\"><a href=\"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/desarrollo-y-funcion-del-sistema-inmunitario\/?lang=es\">Desarrollo y funci\u00f3n del sistema inmunitario <\/a><\/span><\/h6>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_size=&#8221;custom&#8221; background_image_height=&#8221;84%&#8221; background_position=&#8221;bottom_right&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;GRUPO DE INVESTIGACI\u00d3N&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h5&#8243; title_text_color=&#8221;#13B5BD&#8221; custom_margin=&#8221;50px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_blurb title=&#8221;Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe046;||divi||400&#8243; icon_color=&#8221;#13B5BD&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;26px&#8221; content_max_width=&#8221;1100px&#8221; content_max_width_tablet=&#8221;1100px&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.25.2&#8243; header_level=&#8221;h1&#8243; header_font=&#8221;Montserrat||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;29px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;||||||||&#8221; body_font_size=&#8221;15px&#8221; body_line_height=&#8221;1.8em&#8221; image_icon_custom_margin=&#8221;6px||||false|false&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;||14px||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;10%&#8221; animation=&#8221;off&#8221; image_max_width=&#8221;64px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(175,218,249,0.18)&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_4,3_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;\/imgs\/621.jpg&#8221; title_text=&#8221;logoRecurso 7&#8243; align=&#8221;right&#8221; module_class=&#8221;roundedImg&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Aurelio Hidalgo Huertas&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_text_align=&#8221;left&#8221; title_text_color=&#8221;#008C93&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-27px||||false|false&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: left;\"><a href=\"http:\/\/discoverylab.cbm.uam.es\/\" target=\"blank\" rel=\"noopener\">External group website<\/a><\/p>\n<p style=\"text-align: left;\"><a href=\"https:\/\/orcid.org\/0000-0001-5740-5584\" target=\"blank\" rel=\"noopener\">ORCID<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#13B5BD&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#investiga&#8221; button_text=&#8221;Investigaci\u00f3n&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#personal&#8221; button_text=&#8221;Miembros del grupo&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; custom_padding=&#8221;|44px||44px|false|true&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#publica&#8221; button_text=&#8221;Publicaciones&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_size=&#8221;custom&#8221; background_image_height=&#8221;84%&#8221; background_position=&#8221;bottom_right&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||15px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;20px||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;resumen&#8221; module_id=&#8221;resumen&#8221; module_class=&#8221;resumen&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;15px&#8221; text_line_height=&#8221;1.8em&#8221; background_color=&#8221;#f1f8fe&#8221; custom_padding=&#8221;20px|20px|20px|20px|true|false&#8221; border_width_top=&#8221;1px&#8221; border_color_top=&#8221;#008C93&#8243; border_width_bottom=&#8221;1px&#8221; border_color_bottom=&#8221;#008C93&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify;\">El gran reservorio gen\u00e9tico de la naturaleza contiene soluciones para una vida m\u00e1s sana, limpia y sostenible. En el HT Discovery Lab, desarrollamos y utilizamos metodolog\u00edas punteras para descubrir nuevos genes y prote\u00ednas que constituyan una nueva generaci\u00f3n de soluciones para la salud y la industria eficientes justas y sostenibles, apoyando as\u00ed el desarrollo de una bioeconom\u00eda circular europea. <\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;data:image\/svg+xml;base64,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&#8221; title_text=&#8221; &#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Investigaci\u00f3n&#8221; module_id=&#8221;investiga&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify;\">La diversidad microbiana es un vasto reservorio de informaci\u00f3n gen\u00e9tica valorizable mediante su aplicaci\u00f3n industrial, desde clusters biosint\u00e9ticos de mol\u00e9culas bioactivas hasta genes que codifiquen enzimas para biocat\u00e1lisis. La sinergia entre la microbiolog\u00eda y la nanotecnolog\u00eda para desarrollar nuevos m\u00e9todos de cribado es clave para encontrar enzimas de manera m\u00e1s r\u00e1pida y eficiente, permitiendo que los laboratorios acad\u00e9micos desarrollemos campa\u00f1as de cribado hasta ahora limitadas a grandes empresas. <\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/Grupo-Aurelio-Hidalgo.jpg&#8221; title_text=&#8221;Grupo Aurelio Hidalgo&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;60px||||false|false&#8221; custom_padding=&#8221;|||27px||&#8221; animation_style=&#8221;zoom&#8221; border_width_all=&#8221;3px&#8221; border_color_all=&#8221;#13B5BD&#8221; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify;\">En nuestro laboratorio utilizamos selecciones biol\u00f3gicas o m\u00e9todos de cribado de ultra-alta capacidad basados en microflu\u00eddica para encontrar genes y enzimas de inter\u00e9s en la diversidad natural o artificial. Las selecciones biol\u00f3gicas acoplan la mejora en una propiedad de inter\u00e9s a la supervivencia de un hu\u00e9sped bajo presi\u00f3n de selecci\u00f3n. Utilizando este y otros m\u00e9todos de ingenier\u00eda de prote\u00ednas hemos desarrollado variantes estables y solubles de enzimas para biocat\u00e1lisis, como esterasas, deshalogenasas, adem\u00e1s de prote\u00ednas fluorescentes para aplicaciones de localizaci\u00f3n in vivo a altas temperaturas.  <\/p>\n<p style=\"text-align: justify;\">Sin embargo, la complejidad del metabolismo celular limita la aplicaci\u00f3n de las selecciones biol\u00f3gicas. La microflu\u00eddica permite la miniaturizaci\u00f3n de los ensayos, con una reducci\u00f3n de 1000x en coste y volumen, manteniendo velocidades de cribado de varios miles de individuos por segundo. Por lo tanto, el uso de microflu\u00eddica consigue rendimientos similares a las selecciones biol\u00f3gicas evitando la complejidad de las mismas. En el marco del proyecto MetaFluidics, que coordinamos desde este grupo, hemos implementado una plataforma de \u201csorting\u201d basada en fluorescencia para encontrar hidrolasas termoestables en ambientes termales y otras enzimas de relevancia para biocat\u00e1lisis. Para ello, ha habido que desarrollar instrumentaci\u00f3n a la vez que nuevos hu\u00e9spedes y protocolos para expresi\u00f3n funcional compatible con ensayos enzim\u00e1ticos a altas temperaturas.    <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,0,0,0.04)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Miembros del grupo&#8221; module_id=&#8221;personal&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;2560px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_code _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Patricia P\u00e9rez Arnaiz\" image=\"\/imgs\/365.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/>patricia.perez(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Aurelio Hidalgo Huertas\" image=\"\/imgs\/621.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4527<br \/>ahidalgo(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Jorge Diaz-Rullo Aroco\" image=\"\/imgs\/2629.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4524<br \/>jdiaz(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Davide Agostino Cecchini \" image=\"\/imgs\/3011.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/>davide.cecchini(at)uam.es<\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Nargisse Nejda Hamdoun\" image=\"\/imgs\/3228.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4524<br \/>n.nejda(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Laura Blas Mu\u00f1oz\" image=\"\/imgs\/5259.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/>laura.blas(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Laura Pilar Saiz Alvarez\" image=\"\/imgs\/5846.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/>laura.saiz(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Gonzalo Rodrigo Albert\" image=\"\/imgs\/6201.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/>gonzalo.rodrigo(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Sara Trujillo Cubillo\" image=\"\/imgs\/6211.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4525<br \/><\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Pablo Rodr\u00edguez Mateos\" image=\"\/imgs\/6227.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 108 Ext.: 4527<br \/>prodriguez(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Publicaciones representativas&#8221; module_id=&#8221;personal&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/Graphical-Abstract_A-Coupled-Ketoreductase.png&#8221; title_text=&#8221;Imagen sobre la publicaci\u00f3n&#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cssc.202102750&#8243; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>A Coupled Ketoreductase-Diaphorase Assay for the Detection of Polyethylene Terephthalate-Hydrolyzing Activity<\/h3>\n<p>Dr. Mar\u00eda Gimeno-P\u00e9rez et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/Graphical-Abstract_Thermostability-Engineering.webp&#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; title_text=&#8221;Imagen sobre la publicaci\u00f3n&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubs.acs.org\/doi\/10.1021\/acssuschemeng.1c00699&#8243; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Thermostability Engineering of a Class II Pyruvate Aldolase from Escherichia coli by in Vivo Folding Interference<\/h3>\n<p>Sandra Bosch et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/Graphical-Abstract_Thermostability-enhancement.jpeg&#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; title_text=&#8221;Imagen sobre la publicaci\u00f3n&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bit.27170&#8243; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Thermostability enhancement of the Pseudomonas fluorescens esterase I by in vivo folding selection in Thermus thermophilus<\/h3>\n<p>Diana M. Mate et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/10\/Graphical-Abstract_Biobased.gif&#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; title_text=&#8221;Imagen sobre la publicaci\u00f3n&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.7b16639&#8243; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Biobased, Internally pH-Sensitive Materials: Immobilized Yellow Fluorescent Protein as an Optical Sensor for Spatiotemporal Mapping of pH Inside Porous Matrices<\/h3>\n<p>Tanja Consolati et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,0,0,0.04)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;\u00daltimas publicaciones&#8221; module_id=&#8221;publica&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_code _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div data-type=\"items\" data-id=\"1\" data-query=\"e3NvbG9QdWJsaWNhY2lvbmVzQ3NpYzpmYWxzZSx0aXBvbG9naWFzTm9ybWFsaXphZGFzOnRydWUsdGlwb2xvZ2lhc0FydGljdWxvOnRydWUsdGlwb2xvZ2lhc0FydGljdWxvRGVSZXZpc2lvbjp0cnVlLHRpcG9sb2dpYXNDYXBpdHVsb0RlTGlicm86dHJ1ZSx0aXBvbG9naWFzQ2FydGE6dHJ1ZSx0aXBvbG9naWFzTGlicm86dHJ1ZSxvY3VsdGFyRHVwbGljYWRvczp0cnVlLGZ1ZW50ZUZpbHRybzowLGNyaXRlcmlvc0F1dG9yQWZpbDpbImF1dG9yKDI5ODYyKSJdfSA=\" data-fields=\"year;titulo_doi;enlaces_aa;ndoctype;source_norm;cites;authors;publisher\" data-author-max-length=\"500\">Cargando publicaciones&#8230;<\/div>\n<p><!-- [et_pb_line_break_holder] --><script type=\"text\/javascript\" src=\"https:\/\/gesbib.urici.csic.es\/badge\/csi.min.js\"><\/script>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Programas Cient\u00edficos&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;26px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects1_sf.png&#8221; title_text=&#8221; &#8221; url=&#8221;https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/dinamica-y-funcion-del-genoma\/?lang=es&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects2_sf.png&#8221; title_text=&#8221; &#8221; url=&#8221;https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/?lang=es&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects3_sf.png&#8221; title_text=&#8221; &#8221; url=&#8221;https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/procesos-fisiologicos-y-patologicos\/?lang=es&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects4_sf.png&#8221; title_text=&#8221; &#8221; url=&#8221;https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/?lang=es&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Microorganismos en la salud y el bienestar Desarrollo y funci\u00f3n del sistema inmunitario External group website ORCIDEl gran reservorio gen\u00e9tico de la naturaleza contiene soluciones [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":283166,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-280567","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Microorganismos en la salud y el bienestar Desarrollo y funci\u00f3n del sistema inmunitario External group website ORCIDEl gran reservorio gen\u00e9tico de la naturaleza contiene soluciones [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-28T09:29:56+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\\\/?lang=es\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\\\/?lang=es\",\"name\":\"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\"},\"datePublished\":\"2024-07-31T07:00:22+00:00\",\"dateModified\":\"2024-10-28T09:29:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\\\/?lang=es#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\\\/?lang=es\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\\\/?lang=es#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Programas Cient\u00edficos\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Interacciones con el entorno\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Microorganismos en la salud y el bienestar\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/interacciones-con-el-entorno\\\/microorganismos-en-la-salud-y-el-bienestar\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"description\":\"Official website of the CBM, CSIC - UAM. Biomedical research centre.\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"contentUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"width\":800,\"height\":342,\"caption\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es","og_locale":"en_US","og_type":"article","og_title":"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa","og_description":"Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Microorganismos en la salud y el bienestar Desarrollo y funci\u00f3n del sistema inmunitario External group website ORCIDEl gran reservorio gen\u00e9tico de la naturaleza contiene soluciones [&hellip;]","og_url":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es","og_site_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","article_modified_time":"2024-10-28T09:29:56+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es","url":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es","name":"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad - Centro de Biolog\u00eda Molecular Severo Ochoa","isPartOf":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website"},"datePublished":"2024-07-31T07:00:22+00:00","dateModified":"2024-10-28T09:29:56+00:00","breadcrumb":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/descubrimiento-y-mejora-de-proteinas-para-aplicaciones-biotecnologicas-mediante-metodos-de-ultraalta-capacidad\/?lang=es#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.cbm.uam.es\/"},{"@type":"ListItem","position":2,"name":"Programas Cient\u00edficos","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/?lang=es"},{"@type":"ListItem","position":3,"name":"Interacciones con el entorno","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/?lang=es"},{"@type":"ListItem","position":4,"name":"Microorganismos en la salud y el bienestar","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/?lang=es"},{"@type":"ListItem","position":5,"name":"Descubrimiento y mejora de prote\u00ednas para aplicaciones biotecnol\u00f3gicas mediante m\u00e9todos de (ultra)alta capacidad"}]},{"@type":"WebSite","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","description":"Official website of the CBM, CSIC - UAM. Biomedical research centre.","publisher":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cbm.uam.es\/?lang=es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/","url":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","contentUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","width":800,"height":342,"caption":"Centro de Biolog\u00eda Molecular Severo Ochoa"},"image":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/280567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/comments?post=280567"}],"version-history":[{"count":0,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/280567\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/283166"}],"wp:attachment":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/media?parent=280567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}