{"id":280702,"date":"2024-07-31T09:00:21","date_gmt":"2024-07-31T07:00:21","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=280702"},"modified":"2026-04-15T11:00:45","modified_gmt":"2026-04-15T09:00:45","slug":"biotecnologia-de-probioticos-y-patogenos-intestinales","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/microorganismos-en-la-salud-y-el-bienestar\/biotecnologia-de-probioticos-y-patogenos-intestinales\/?lang=es","title":{"rendered":"Biotecnolog\u00eda de probi\u00f3ticos y pat\u00f3genos intestinales"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; background_image=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/iStock-1833377669small-scaled.jpg&#8221; background_position=&#8221;bottom_center&#8221; background_vertical_offset=&#8221;32%&#8221; min_height=&#8221;352px&#8221; height=&#8221;294px&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; custom_margin=&#8221;61px||||false|false&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(52,96,155,0.83)&#8221; custom_padding=&#8221;50px||50px|50px|false|false&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;0px||10px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Programa Cient\u00edfico<\/p>\n<p>[\/et_pb_text][et_pb_heading title=&#8221;Interacciones con el entorno&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;Montserrat||||||||&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;43px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;157px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4 style=\"text-align: center\"><span style=\"color: #13b5bd\">UNIDADES EN ESTE PROGRAMA<br \/>\n<\/span><\/h4>\n<hr>\n<h6 style=\"text-align: center\"><span style=\"color: #13b5bd\"><br \/>\n<a href=\"\/index.php\/scientific-programs\/interactions-with-the-environment\/microbes-in-health-and-welfare\/\">Microorganismos en la salud y el bienestar<\/a><\/span> <span style=\"color: #abb8c3\"><a href=\"\/index.php\/scientific-programs\/interactions-with-the-environment\/immune-system-development-and-function\/\">Desarrollo y funci\u00f3n del sistema inmunitario<\/a><\/span> <\/h6>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_size=&#8221;custom&#8221; background_image_height=&#8221;84%&#8221; background_position=&#8221;bottom_right&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;GRUPO DE INVESTIGACI\u00d3N&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h5&#8243; title_text_color=&#8221;#13B5BD&#8221; custom_margin=&#8221;50px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_blurb title=&#8221;Biotecnolog\u00eda de probi\u00f3ticos y pat\u00f3genos intestinales&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe046;||divi||400&#8243; icon_color=&#8221;#13B5BD&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;26px&#8221; content_max_width=&#8221;1100px&#8221; content_max_width_tablet=&#8221;1100px&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.25.2&#8243; header_level=&#8221;h1&#8243; header_font=&#8221;Montserrat||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;29px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;||||||||&#8221; body_font_size=&#8221;15px&#8221; body_line_height=&#8221;1.8em&#8221; image_icon_custom_margin=&#8221;6px||||false|false&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;||14px||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;10%&#8221; animation=&#8221;off&#8221; image_max_width=&#8221;64px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(175,218,249,0.18)&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_4,3_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;\/imgs\/5712.jpg&#8221; title_text=&#8221;logoRecurso 7&#8243; align=&#8221;right&#8221; module_class=&#8221;roundedImg&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;David Ruano Gallego&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_text_align=&#8221;left&#8221; title_text_color=&#8221;#008C93&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-27px||||false|false&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: left\"><a href=\"https:\/\/twitter.com\/druanogallego\/status\/1370287186587815943\" target=\"blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2024\/01\/ico_twitter.png\" width=\"24\" height=\"25\" style=\"margin-top: -2px;margin-left: -2px\" alt=\"\" class=\"wp-image-277817 alignleft size-full\"><\/a><a href=\"https:\/\/www.researchgate.net\/profile\/David-Ruano-Gallego\" target=\"blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/ResearchGate.png\" width=\"24\" height=\"25\" style=\"margin-top: -2px;margin-left: -2px\" alt=\"\" class=\"wp-image-277817 alignleft size-full\"><\/a><a href=\"https:\/\/www.linkedin.com\/in\/druanogallego\/\" target=\"blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/LinkedIn.png\" width=\"24\" height=\"25\" style=\"margin-top: -2px;margin-left: -2px\" alt=\"\" class=\"wp-image-277817 alignleft size-full\"><\/a><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-2163-2088\" target=\"blank\" rel=\"noopener\">ORCID<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#13B5BD&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#investiga&#8221; button_text=&#8221;Investigaci\u00f3n&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#personal&#8221; button_text=&#8221;Miembros del grupo&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; custom_padding=&#8221;|44px||44px|false|true&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;#publica&#8221; button_text=&#8221;Publicaciones&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#34609B&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_size=&#8221;custom&#8221; background_image_height=&#8221;84%&#8221; background_position=&#8221;bottom_right&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||15px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;20px||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;resumen&#8221; module_id=&#8221;resumen&#8221; module_class=&#8221;resumen&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;15px&#8221; text_line_height=&#8221;1.8em&#8221; background_color=&#8221;#f1f8fe&#8221; custom_padding=&#8221;20px|20px|20px|20px|true|false&#8221; border_width_top=&#8221;1px&#8221; border_color_top=&#8221;#008C93&#8243; border_width_bottom=&#8221;1px&#8221; border_color_bottom=&#8221;#008C93&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\">El sistema digestivo est\u00e1 ampliamente estudiado, pero no tanto su funcionamiento durante la disbiosis intestinal, como la inflamaci\u00f3n y la infecci\u00f3n. Especialmente, considerando lo poco que conocemos sobre el papel de miembros clave de la microbiota. Queremos desentra\u00f1ar las interacciones pat\u00f3geno-hospedador y desarrollar estrategias basadas en bacterias para tratar enfermedades intestinales.  <\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/1080&#215;360-transformed-David-Ruano-scaled.jpeg&#8221; title_text=&#8221; &#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Investigaci\u00f3n&#8221; module_id=&#8221;investiga&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\">El intestino desempe\u00f1a un papel fundamental en nuestro cuerpo, no solo en la absorci\u00f3n de nutrientes de los alimentos que ingerimos, sino tambi\u00e9n en albergar una compleja red de interacciones que involucran a los enterocitos intestinales (c\u00e9lulas que recubren el intestino), las bacterias del microbioma (microorganismos que habitan en el intestino) y el sistema inmunol\u00f3gico. Los cambios en estos factores pueden perturbar la estabilidad de estas interacciones, lo que permite que bacterias da\u00f1inas invadan el intestino y causen enfermedades. <\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/04\/2026-04-09-Grupo-David-Ruano-13SELBet-1000px.jpg&#8221; title_text=&#8221;2026-04-09 Grupo David Ruano 13SELBet-1000px&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;60px||||false|false&#8221; custom_padding=&#8221;|||27px||&#8221; animation_style=&#8221;zoom&#8221; hover_enabled=&#8221;0&#8243; border_width_all=&#8221;3px&#8221; border_color_all=&#8221;#13B5BD&#8221; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\">En nuestro laboratorio de investigaci\u00f3n, nos enfocamos en estudiar c\u00f3mo las bacterias pat\u00f3genas utilizan un mecanismo especializado llamado Sistema de Secreci\u00f3n Tipo 3 para infectar el intestino y evadir las defensas del sistema inmunol\u00f3gico. Estas bacterias emplean prote\u00ednas espec\u00edficas conocidas como prote\u00ednas efectoras, que establecen una red de interacciones crucial para su proceso de infecci\u00f3n. Nuestro objetivo es desentra\u00f1ar esta red de interacciones de prote\u00ednas para comprender mejor c\u00f3mo ocurren las infecciones y c\u00f3mo responde el sistema inmunol\u00f3gico a diferentes estrategias de infecci\u00f3n. Para lograr esto, hemos creado cepas mutantes de estas bacterias pat\u00f3genas. Luego, utilizamos estos mutantes para infectar ratones y observar los efectos que tienen en el intestino. Esto nos permite obtener informaci\u00f3n sobre los mecanismos detr\u00e1s de la infecci\u00f3n y la inmunidad.     <\/p>\n<p style=\"text-align: justify\"><span>Adem\u00e1s, aspiramos a aprovechar el poder de los probi\u00f3ticos para aplicaciones biotecnol\u00f3gicas en el campo de la biomedicina. Utilizando t\u00e9cnicas avanzadas de biolog\u00eda sint\u00e9tica, pretendemos desarrollar m\u00e9todos para manipular cepas de bacterias poco conocidas. Estas cepas bacterianas tienen el potencial de servir como indicadores de buena salud y ofrecer protecci\u00f3n contra enfermedades intestinales. Nuestra investigaci\u00f3n busca impulsar las capacidades de estos probi\u00f3ticos como herramientas valiosas para mejorar la salud humana.   <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,0,0,0.04)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Miembros del grupo&#8221; module_id=&#8221;personal&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;2560px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_code _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"David Ruano Gallego\" image=\"\/imgs\/5712.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 114.1 Ext.: 4579 <br \/>druano(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Laura G\u00f3mez Ruiz\" image=\"\/imgs\/5943.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/>laura.gomez(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Ana Jim\u00e9nez Guti\u00e9rrez\" image=\"\/imgs\/6041.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/>ana.jimenez(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Alfonso Santos Lopez\" image=\"\/imgs\/default.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/>alfonso.santos(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Alejandro Viru\u00e9s Morales\" image=\"\/imgs\/6453.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/>alejandro.virues(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Leyre V\u00e9lez Fern\u00e1ndez\" image=\"\/imgs\/6487.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/><\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\" Marta Garc\u00eda Ruiz\" image=\"\/imgs\/6566.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]<p>Lab.: 104 Ext.: 4678<br \/><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Publicaciones representativas&#8221; module_id=&#8221;personal&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px|||0px|false|false&#8221; custom_padding=&#8221;3px|||8px|false|false&#8221; border_width_left=&#8221;6px&#8221; border_color_left=&#8221;#34609B&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/1-David-Ruano.jpeg&#8221; title_text=&#8221; &#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/33707240\/&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Type III secretion system effectors form robust and flexible intracellular virulence networks<\/h3>\n<p>David Ruano-Gallego et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/2-David-Ruano.jpg&#8221; title_text=&#8221; &#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/34840074\/&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>The type III secretion system effector network hypothesis<\/h3>\n<p>Julia Sanchez-Garrido et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;zoom&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/3-David-Ruano.jpg&#8221; title_text=&#8221; &#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/31465434\/&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>A nanobody targeting the translocated intimin receptor inhibits the attachment of enterohemorrhagic E. coli to human colonic mucosa<\/h3>\n<p>David Ruano-Gallego et al<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/06\/4-David-Ruano.jpg&#8221; title_text=&#8221; &#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/30857538\/&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Screening and purification of nanobodies from E. coli culture supernatants using the hemolysin secretion system<\/h3>\n<p>David Ruano-Gallego et al.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,0,0,0.04)&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; 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global_colors_info=&#8221;{}&#8221;]<\/p>\n<div data-type=\"items\" data-id=\"1\" data-query=\"e3NvbG9QdWJsaWNhY2lvbmVzQ3NpYzpmYWxzZSx0aXBvbG9naWFzTm9ybWFsaXphZGFzOnRydWUsdGlwb2xvZ2lhc0FydGljdWxvOnRydWUsdGlwb2xvZ2lhc0FydGljdWxvRGVSZXZpc2lvbjp0cnVlLHRpcG9sb2dpYXNDYXBpdHVsb0RlTGlicm86dHJ1ZSx0aXBvbG9naWFzQ2FydGE6dHJ1ZSx0aXBvbG9naWFzTGlicm86dHJ1ZSxvY3VsdGFyRHVwbGljYWRvczp0cnVlLGZ1ZW50ZUZpbHRybzowLGNyaXRlcmlvc0F1dG9yQWZpbDpbImF1dG9yKDY3MDE1KSJdfSA=\" data-fields=\"year;titulo_doi;enlaces_aa;ndoctype;source_norm;cites;authors;publisher\" data-author-max-length=\"500\">Cargando publicaciones&#8230;<\/div>\n<p><!-- [et_pb_line_break_holder] -->[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#34609B&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Programas cient\u00edficos&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;26px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.25.0&#8243; 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