{"id":284632,"date":"2024-08-28T08:37:37","date_gmt":"2024-08-28T06:37:37","guid":{"rendered":"https:\/\/dhcp205002.cbm.uam.es\/?page_id=284632"},"modified":"2025-01-01T13:16:32","modified_gmt":"2025-01-01T12:16:32","slug":"virus-cell-interaction-the-asfv-model","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/interactions-with-the-environment\/microbes-in-health-and-welfare\/virus-cell-interaction-the-asfv-model\/","title":{"rendered":"Virus-Cell interaction. The ASFV model"},"content":{"rendered":"

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Scientific Program<\/p>\n

[\/et_pb_text][et_pb_heading title=”Interactions with the environment” _builder_version=”4.27.0″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNITS IN THIS PROGRAM
\n<\/span><\/h4>\n
\n

\nMicrobes in health and welfare<\/a><\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Immune system development and function<\/a><\/span><\/h6>\n

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ORCID<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#investiga” button_text=”Research” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#personal” button_text=”Group members” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” custom_padding=”|44px||44px|false|true” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#publica” button_text=”Publications” button_alignment=”center” _builder_version=”4.25.0″ _module_preset=”default” custom_button=”on” button_bg_color=”#34609B” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”20px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”resumen” module_id=”resumen” module_class=”resumen” _builder_version=”4.27.0″ _module_preset=”default” text_font_size=”15px” text_line_height=”1.8em” background_color=”#f1f8fe” custom_padding=”20px|20px|20px|20px|true|false” border_width_top=”1px” border_color_top=”#008C93″ border_width_bottom=”1px” border_color_bottom=”#008C93″ global_colors_info=”{}”]<\/p>\n

Dr Revilla’s laboratory studies different molecular aspects of the interaction of African swine fever virus (ASFV) with its target cell, addressing the mechanisms of tropism, virulence genes and viral control of the immune system. This has allowed us to generate vaccine candidates using CRISPR\/Cas9. ASFV represents the largest animal pandemic worldwide, and the development of safe and effective vaccines is urgently needed.<\/p>\n

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The African swine fever virus (ASFV) laboratory, directed by Dr. Yolanda Revilla, studies the complex viral and cellular mechanisms that occur during ASFV infection. The natural target cell of this virus is exclusively porcine monocytes and macrophages, so the viral and cellular factors that determine its tropism are a focus of attention in our laboratory. Another relevant objective is the molecular mechanisms involved in ASFV virulence, which are directly related to the control that the virus exerts on different branches of the immune response of the infected animal, and, in particular, on the innate response by regulating type I IFN, as we have described in the group. In addition, we are interested in generating vaccine candidates against ASFV based, fundamentally, on live attenuated vaccines (LAVs) and, very recently, also based on only partially replicative prototypes, which constitutes a first in the field and would be a great advance in terms of safety. To this end, we addressed the study of virus-host interaction using cell biology, biochemical, microscopy and cytometry techniques, together with the generation of recombinant viruses using CRISPR-Cas9 technology (adapted to ASFV biology by Dr. Daniel P\u00e9rez N\u00fa\u00f1ez, senior postdoc in the group), as well as their genetic characterization using NGS techniques such as Illumina and Nanopore. We also collaborate actively with other research centers and companies, both in Spain, Europe and Asia, to analyze and evaluate the behavior of ASFV in vivo, as well as the protective immune response of the different vaccine prototypes.<\/p>\n

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ASFV infects domestic pigs and wild boars and is currently the great animal pandemic, being the biggest problem of the world swine industry as well as being responsible for a major ecological calamity. Since 2007 an outbreak in the Caucasus, ASFV has been spreading through Russia towards Eastern Europe, and is now widespread in Europe, Asia (particularly China) and Africa, where it is endemic, as well as being present in Oceania and the Caribbean, seriously threatening to further spread to the Americas. Molecular studies of virus-cell interaction, as well as the generation of vaccine prototypes, will contribute in the mid and long term to contain and prevent the great threat currently represented by ASFV.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.04)” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Group members” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.0″ _module_preset=”default” max_width=”2560px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_code _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=\"4.25.0\" _module_preset=\"default\" column_structure=\"1_4,1_4,1_4,1_4\" hover_enabled=\"0\" sticky_enabled=\"0\"][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Yolanda Revilla Novella\" image=\"\/imgs\/40.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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yrevilla(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Carmen M\u00aa S\u00e1nchez-Valdepe\u00f1as Villegas\" image=\"\/imgs\/265.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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csanchez-valdepenias(at)cbm.csic.es<\/p>[\/et_pb_blurb][\/et_pb_column][et_pb_column _builder_version=\"4.25.0\" _module_preset=\"default\" type=\"1_4\"][et_pb_blurb title=\"Daniel P\u00e9rez N\u00fa\u00f1ez\" image=\"\/imgs\/1539.jpg\" _builder_version=\"4.25.0\" _module_preset=\"default\" header_text_align=\"center\" body_text_align=\"center\" global_colors_info=\"{}\" theme_builder_area=\"post_content\" module_class=\"roundedImg\"]

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African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells<\/h3>\n

Elena G. S\u00e1nchez et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/08\/2-Grupo-Yolanda-Revilla.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/30918080\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

African Swine Fever Virus Armenia\/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway<\/h3>\n

Raquel Garc\u00eda-Belmonte et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/08\/3-Grupo-Yolanda-Revilla.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36560402\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Recombinant African Swine Fever Virus Arm\/07\/CBM\/c2 Lacking CD2v and A238L Is Attenuated and Protects Pigs against Virulent Korean Paju Strain<\/h3>\n

Daniel P\u00e9rez-N\u00fa\u00f1ez et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/08\/4-Grupo-Yolanda-Revilla.jpg” title_text=” ” url_new_window=”on” _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.0″ _module_preset=”default” link_option_url=”https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01030-23″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Signal peptide and N-glycosylation of N-terminal-CD2v determine the hemadsorption of African swine fever virus<\/h3>\n

Daniel P\u00e9rez-N\u00fa\u00f1ez et al.<\/p>\n

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