{"id":293417,"date":"2026-01-14T09:07:22","date_gmt":"2026-01-14T08:07:22","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?page_id=293417"},"modified":"2026-01-14T10:13:07","modified_gmt":"2026-01-14T09:13:07","slug":"inestabilidad-cromosomica-cancer-e-inmunidad","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/comunicacion-intercelular-e-inflamacion\/inestabilidad-cromosomica-cancer-e-inmunidad\/?lang=es","title":{"rendered":"Inestabilidad cromos\u00f3mica, cancer e inmunidad"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” background_color=”#34609B” background_image=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/iStock-1284442724small-scaled.jpg” background_position=”bottom_center” background_vertical_offset=”32%” min_height=”352px” height=”294px” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”2_5,3_5″ use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” custom_margin=”61px||||false|false” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(52,96,155,0.83)” custom_padding=”50px||50px|50px|false|false” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_margin=”0px||10px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

Programa Cient\u00edfico<\/p>\n

[\/et_pb_text][et_pb_heading title=”Homeostasis de tejidos y \u00f3rganos” _builder_version=”4.27.5″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNIDADES EN ESTE PROGRAMA
\n<\/span><\/h4>\n
\n

\nArquitectura celular y organog\u00e9nesis <\/a><\/span> Comunicaci\u00f3n intercelular e inflamaci\u00f3n<\/a><\/span><\/h6>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”IP JUNIOR” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h5″ title_text_color=”#13B5BD” custom_margin=”50px||0px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_blurb title=”Inestabilidad cromos\u00f3mica, cancer e inmunidad” use_icon=”on” font_icon=”||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”26px” content_max_width=”1100px” content_max_width_tablet=”1100px” content_max_width_last_edited=”off|desktop” _builder_version=”4.23.4″ header_level=”h1″ header_font=”Montserrat||||||||” header_text_color=”#000000″ header_font_size=”29px” header_line_height=”1.4em” body_font=”||||||||” body_font_size=”15px” body_line_height=”1.8em” image_icon_custom_margin=”6px||||false|false” background_layout=”dark” custom_margin=”|||” custom_padding=”||14px||false|false” animation_style=”slide” animation_direction=”right” animation_intensity_slide=”10%” animation=”off” image_max_width=”64px” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(175,218,249,0.18)” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”\/imgs\/6047.jpg” title_text=”logoRecurso 7″ align=”right” module_class=”roundedImg” _builder_version=”4.27.5″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Carolina Villarroya Beltri” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ title_text_align=”left” title_text_color=”#008C93″ global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”40px||||false|false” custom_padding=”20px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Investigaci\u00f3n” module_id=”investiga” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

La inestabilidad cromos\u00f3mica se define como una mayor propensi\u00f3n a cometer errores en la segregaci\u00f3n de los cromosomas durante la divisi\u00f3n celular. Como consecuencia, las c\u00e9lulas con inestabilidad cromos\u00f3mica con frecuencia ganan o pierden cromosomas, generando c\u00e9lulas hijas aneuploides. La aneuploid\u00eda, que es la condici\u00f3n de poseer un n\u00famero anormal de cromosomas, se encuentra en aproximadamente el 90 % de los tumores humanos, mientras que es extremadamente rara en tejidos normales. M\u00faltiples l\u00edneas de evidencia indican que la aneuploid\u00eda no es solo una caracter\u00edstica distintiva del c\u00e1ncer, sino tambi\u00e9n una fuerza impulsora; sin embargo, hist\u00f3ricamente ha sido tratada como una consecuencia pasiva del c\u00e1ncer, y su potencial como vulnerabilidad terap\u00e9utica permanece en gran medida inexplorado. En nuestro laboratorio buscamos descifrar c\u00f3mo la inestabilidad cromos\u00f3mica y las respuestas celulares al estr\u00e9s moldean la adaptaci\u00f3n tumoral, la resistencia a las terapias y las interacciones con el sistema inmunitario. <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

La consecuencia molecular m\u00e1s inmediata de ganar o perder una copia de un cromosoma es un desequilibrio en la expresi\u00f3n de los genes codificados en el cromosoma que se gana o se pierde. Como resultado, las c\u00e9lulas aneuploides presentan cambios en la expresi\u00f3n g\u00e9nica y una respuesta al estr\u00e9s que, por lo general, conduce a una proliferaci\u00f3n reducida y a la activaci\u00f3n de IFN, independientemente del cromosoma afectado. Sin embargo, a pesar de estos costes iniciales en t\u00e9rminos de aptitud celular, las c\u00e9lulas aneuploides pueden adaptarse con el tiempo, dando lugar a clones con ventajas selectivas. En nuestro laboratorio queremos comprender c\u00f3mo las c\u00e9lulas aneuploides se adaptan a esta condici\u00f3n y c\u00f3mo esta respuesta al estr\u00e9s inducida por la aneuploid\u00eda afecta a su interacci\u00f3n con el sistema inmunitario. Para ello trabajamos con modelos celulares y de rat\u00f3n de inestabilidad cromos\u00f3mica, as\u00ed como con muestras humanas de pacientes con aneuploid\u00eda variegada en mosaico (Mosaic Variegated Aneuploidy, MVA). Estos individuos presentan mutaciones en genes que codifican prote\u00ednas implicadas en la correcta segregaci\u00f3n de los cromosomas durante la mitosis y, como consecuencia, se generan continuamente c\u00e9lulas aneuploides que afectan a distintos cromosomas y que representan entre el 10 % y el 40 % del total de sus c\u00e9lulas. Por tanto, estos pacientes constituyen un escenario \u00fanico para comprender las consecuencias de la aneuploid\u00eda en humanos, incluido su papel en la transformaci\u00f3n celular y la interacci\u00f3n de las c\u00e9lulas aneuploides con el sistema inmunitario. <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.04)” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Publicaciones representativas” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/Villarroya-Beltri-Nat-Rev-Gen-2024.png” title_text=”Villarroya Beltri Nat Rev Gen 2024″ url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/39169218\/” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/39169218\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Mosaic variegated aneuploidy in development, ageing and cancer<\/h3>\n

Malumbres, M. et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/Villarroya-Beltri-et-al.-EMBO-J-2023.png” title_text=”Villarroya-Beltri et al. EMBO J 2023 ” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36326833\/” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36326833\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells<\/h3>\n

Villarroya-Beltri, C. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/Villarroya-Beltri-et-al.-Sci-Adv-2022.png” title_text=”Villarroya-Beltri et al. Sci Adv 2022 ” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36322655\/” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36322655\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Biallelic germline mutations in MAD1L1 induce a syndrome of aneuploidy with high tumor susceptibility<\/h3>\n

Villarroya-Beltri, C. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/Villarroya-Beltri-Cancer-Res-2022.png” title_text=”Villarroya-Beltri Cancer Res 2022″ url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36193651\/” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36193651\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Mitotic Checkpoint Imbalances in Familial Cancer<\/h3>\n

Villarroya-Beltri, C. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#34609B” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Programas cient\u00edficos” _builder_version=”4.25.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font_size=”26px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”0px|0px|0px|0px|false|true” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects1_sf.png” title_text=”areas_proyects1_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/dinamica-y-funcion-del-genoma\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects2_sf.png” title_text=”areas_proyects2_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects3_sf.png” title_text=”areas_proyects3_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/procesos-fisiologicos-y-patologicos\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects4_sf.png” title_text=”areas_proyects4_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Arquitectura celular y organog\u00e9nesis Comunicaci\u00f3n intercelular e inflamaci\u00f3nLa inestabilidad cromos\u00f3mica se define como una mayor propensi\u00f3n a cometer errores en la segregaci\u00f3n de los cromosomas […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":283190,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-293417","page","type-page","status-publish","hentry"],"yoast_head":"\nInestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Arquitectura celular y organog\u00e9nesis Comunicaci\u00f3n intercelular e inflamaci\u00f3nLa inestabilidad cromos\u00f3mica se define como una mayor propensi\u00f3n a cometer errores en la segregaci\u00f3n de los cromosomas […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-14T09:13:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"13 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-cell-communication-and-inflammation\\\/chromosome-instability-cancer-and-immunity\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-cell-communication-and-inflammation\\\/chromosome-instability-cancer-and-immunity\\\/\",\"name\":\"Inestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\"},\"datePublished\":\"2026-01-14T08:07:22+00:00\",\"dateModified\":\"2026-01-14T09:13:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-cell-communication-and-inflammation\\\/chromosome-instability-cancer-and-immunity\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-cell-communication-and-inflammation\\\/chromosome-instability-cancer-and-immunity\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-cell-communication-and-inflammation\\\/chromosome-instability-cancer-and-immunity\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Programas Cient\u00edficos\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Homeostasis de tejidos y \u00f3rganos\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/homeostasis-de-tejidos-y-organos\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Comunicaci\u00f3n intercelular e inflamaci\u00f3n\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/programas-cientificos\\\/homeostasis-de-tejidos-y-organos\\\/comunicacion-intercelular-e-inflamacion\\\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Inestabilidad cromos\u00f3mica, cancer e inmunidad\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"description\":\"Official website of the CBM, CSIC - UAM. Biomedical research centre.\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"contentUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"width\":800,\"height\":342,\"caption\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Inestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/","og_locale":"en_US","og_type":"article","og_title":"Inestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa","og_description":"Programa Cient\u00edficoUNIDADES EN ESTE PROGRAMA Arquitectura celular y organog\u00e9nesis Comunicaci\u00f3n intercelular e inflamaci\u00f3nLa inestabilidad cromos\u00f3mica se define como una mayor propensi\u00f3n a cometer errores en la segregaci\u00f3n de los cromosomas […]","og_url":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/","og_site_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","article_modified_time":"2026-01-14T09:13:07+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"13 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/","url":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/","name":"Inestabilidad cromos\u00f3mica, cancer e inmunidad - Centro de Biolog\u00eda Molecular Severo Ochoa","isPartOf":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website"},"datePublished":"2026-01-14T08:07:22+00:00","dateModified":"2026-01-14T09:13:07+00:00","breadcrumb":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-cell-communication-and-inflammation\/chromosome-instability-cancer-and-immunity\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.cbm.uam.es\/?lang=es"},{"@type":"ListItem","position":2,"name":"Programas Cient\u00edficos","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/?lang=es"},{"@type":"ListItem","position":3,"name":"Homeostasis de tejidos y \u00f3rganos","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/?lang=es"},{"@type":"ListItem","position":4,"name":"Comunicaci\u00f3n intercelular e inflamaci\u00f3n","item":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/comunicacion-intercelular-e-inflamacion\/?lang=es"},{"@type":"ListItem","position":5,"name":"Inestabilidad cromos\u00f3mica, cancer e inmunidad"}]},{"@type":"WebSite","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","description":"Official website of the CBM, CSIC - UAM. Biomedical research centre.","publisher":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cbm.uam.es\/?lang=es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/","url":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","contentUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","width":800,"height":342,"caption":"Centro de Biolog\u00eda Molecular Severo Ochoa"},"image":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/293417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/comments?post=293417"}],"version-history":[{"count":8,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/293417\/revisions"}],"predecessor-version":[{"id":293496,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/293417\/revisions\/293496"}],"up":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/pages\/283190"}],"wp:attachment":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/media?parent=293417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}