{"id":293629,"date":"2026-01-23T09:02:51","date_gmt":"2026-01-23T08:02:51","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?page_id=293629"},"modified":"2026-01-23T09:02:51","modified_gmt":"2026-01-23T08:02:51","slug":"drosophila-central-nervous-system-morphogenesis","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-architecture-and-organogenesis\/drosophila-central-nervous-system-morphogenesis\/","title":{"rendered":"Drosophila Central Nervous System morphogenesis"},"content":{"rendered":"

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Scientific Program<\/p>\n

[\/et_pb_text][et_pb_heading title=”Tissue and organ homeostasis” _builder_version=”4.27.5″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

UNITS IN THIS PROGRAM
\n<\/span><\/h4>\n
\n

\nCell architecture and organogenesis<\/a><\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cell-cell communication and inflammation<\/a><\/span><\/h6>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”JUNIOR PI” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h5″ title_text_color=”#13B5BD” custom_margin=”50px||0px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_blurb title=”Drosophila Central Nervous System morphogenesis” use_icon=”on” font_icon=”||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”26px” content_max_width=”1100px” content_max_width_tablet=”1100px” content_max_width_last_edited=”off|desktop” _builder_version=”4.27.5″ header_level=”h1″ header_font=”Montserrat||||||||” header_text_color=”#000000″ header_font_size=”29px” header_line_height=”1.4em” body_font=”||||||||” body_font_size=”15px” body_line_height=”1.8em” image_icon_custom_margin=”6px||||false|false” background_layout=”dark” custom_margin=”|||” custom_padding=”||14px||false|false” animation_style=”slide” animation_direction=”right” animation_intensity_slide=”10%” animation=”off” image_max_width=”64px” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(175,218,249,0.18)” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/07\/persona.png” title_text=”persona” align=”right” module_class=”roundedImg” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Katerina Karkali” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ title_text_align=”left” title_text_color=”#008C93″ global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” 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custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Animal behaviors are driven by the integration of interoceptive and exteroceptive inputs mediated by the Central Nervous System (CNS) neuronal circuits. While significant effort is currently placed in deciphering the connectomes of different organisms, the contribution of the tissue\u2019s structural organization to its integrative capacity has been comparatively understudied. In this context, glial networks and the extracellular matrix (ECM) together form a dynamic, interdependent structural unit that landscapes the CNS.<\/p>\n

As a Ram\u00f3n y Cajal Investigator at the CBM I study how the dynamic developmental interplay between glia and ECM contributes to CNS morphogenesis and function. To address this issue, I employ the Drosophila<\/em> embryonic CNS as a model system, focusing on the condensation of the Ventral Nerve Cord (VNC). Midway through embryogenesis, and simultaneously to neural circuits assembly into an array of interconnected neural modules, the VNC undergoes a dramatic condensation associated with the onset of motor coordination and embryo hatching. VNC condensation represents a novel model for investigating the relationship between structure and function, as it is highly sensitive to architectural changes and linked to a clear behavioral output: the embryo\u2019s ability to perform peristalsis and successfully hatch.<\/p>\n

Employing FIB-SEM-based 3D tissue segmentation, high-resolution confocal microscopy, and advanced image processing techniques, I pursue two main objectives:<\/p>\n

1. Examine how glia networks assemble and dynamically interact with the ECM during CNS development.<\/p>\n

2. Evaluate how glia – ECM material properties influence the mechanical equilibrium of the tissue and impact neural circuits\u2019 function.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.04)” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Selected publications” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-1.jpg” title_text=”pub 1″ url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580722001678?via%3Dihub” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580722001678?via%3Dihub” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Condensation of the Drosophila<\/em> nerve cord is oscillatory and depends on coordinated mechanical interactions<\/h3>\n

Karkali, K. et al.<\/p>\n

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JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila <\/em>embryos<\/h3>\n

Karkali, K. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-3.png” title_text=”pub 3″ url=”https:\/\/www.nature.com\/articles\/s41467-023-43783-1″ url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.nature.com\/articles\/s41467-023-43783-1″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Puckered and JNK signaling in pioneer neurons coordinate the motor activity of the Drosophila<\/em> embryo<\/h3>\n

Karkali, K. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-4.jpg” title_text=”pub 4″ url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266616672200781X?via%3Dihub” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266616672200781X?via%3Dihub” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Measuring ventral nerve cord stiffness in live flat-dissected Drosophila<\/em> embryos by atomic force microscopy<\/h3>\n

Karkali, K. et al<\/p>\n

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Scientific ProgramUNITS IN THIS PROGRAM Cell architecture and organogenesis\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cell-cell communication and inflammationAnimal behaviors are driven by the integration of interoceptive and exteroceptive inputs mediated by […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":278643,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-293629","page","type-page","status-publish","hentry"],"yoast_head":"\nDrosophila Central Nervous System morphogenesis - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-architecture-and-organogenesis\/drosophila-central-nervous-system-morphogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drosophila Central Nervous System morphogenesis - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"Scientific ProgramUNITS IN THIS PROGRAM Cell architecture and organogenesis\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cell-cell communication and inflammationAnimal behaviors are driven by the integration of interoceptive and exteroceptive inputs mediated by […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbm.uam.es\/index.php\/scientific-programs\/tissue-and-organ-homeostasis\/cell-architecture-and-organogenesis\/drosophila-central-nervous-system-morphogenesis\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/drosophila-central-nervous-system-morphogenesis\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/drosophila-central-nervous-system-morphogenesis\\\/\",\"name\":\"Drosophila Central Nervous System morphogenesis - Centro de Biolog\u00eda Molecular Severo Ochoa\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\"},\"datePublished\":\"2026-01-23T08:02:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/drosophila-central-nervous-system-morphogenesis\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/drosophila-central-nervous-system-morphogenesis\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/drosophila-central-nervous-system-morphogenesis\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific programs\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Tissue and organ homeostasis\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Cell architecture and organogenesis\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/scientific-programs\\\/tissue-and-organ-homeostasis\\\/cell-architecture-and-organogenesis\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Drosophila Central Nervous System morphogenesis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"description\":\"Official website of the CBM, CSIC - UAM. 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