{"id":293644,"date":"2026-01-23T09:02:51","date_gmt":"2026-01-23T08:02:51","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?page_id=293644"},"modified":"2026-09-29T12:25:45","modified_gmt":"2026-09-29T10:25:45","slug":"morfogenesis-del-sistema-nervioso-central-de-drosophila","status":"publish","type":"page","link":"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/arquitectura-celular-y-organogenesis\/morfogenesis-del-sistema-nervioso-central-de-drosophila\/?lang=es","title":{"rendered":"Morfog\u00e9nesis del sistema nervioso central de Drosophila"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” background_color=”#34609B” background_image=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/07\/iStock-1284442724small-scaled.jpg” background_position=”bottom_center” background_vertical_offset=”32%” min_height=”352px” height=”294px” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”2_5,3_5″ use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” custom_margin=”61px||||false|false” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(52,96,155,0.83)” custom_padding=”50px||50px|50px|false|false” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_margin=”0px||10px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

Programa Cient\u00edfico<\/p>\n

[\/et_pb_text][et_pb_heading title=”Homeostasis de tejidos y \u00f3rganos” _builder_version=”4.27.5″ _module_preset=”default” title_font=”Montserrat||||||||” title_text_color=”#FFFFFF” title_font_size=”43px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”157px||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

UNITS IN THIS PROGRAM
\n<\/span><\/h4>\n\n

\nCell architecture and organogenesis<\/a><\/span> Cell-cell communication and inflammation<\/a><\/span><\/h6>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”IP JUNIOR” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h5″ title_text_color=”#13B5BD” custom_margin=”50px||0px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_blurb title=”Drosophila Central Nervous System morphogenesis” use_icon=”on” font_icon=”||divi||400″ icon_color=”#13B5BD” icon_placement=”left” image_icon_width=”26px” content_max_width=”1100px” content_max_width_tablet=”1100px” content_max_width_last_edited=”off|desktop” _builder_version=”4.27.9″ header_level=”h1″ header_font=”Montserrat||||||||” header_text_color=”#000000″ header_font_size=”29px” header_line_height=”1.4em” body_font=”||||||||” body_font_size=”15px” body_line_height=”1.8em” image_icon_custom_margin=”6px||||false|false” background_layout=”dark” custom_margin=”|||” custom_padding=”||14px||false|false” animation_style=”slide” animation_direction=”right” animation_intensity_slide=”10%” animation=”off” hover_enabled=”0″ image_max_width=”64px” global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(175,218,249,0.18)” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/imgs\/6198.jpg” title_text=”persona” align=”right” module_class=”roundedImg” _builder_version=”4.27.7″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Katerina Karkali” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ title_text_align=”left” title_text_color=”#008C93″ global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.9″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

ORCID<\/a><\/p>\n

[\/et_pb_text][et_pb_heading title=”Lab 414 Ext: 4465″ _builder_version=”4.27.7″ _module_preset=”default” title_level=”h5″ title_text_align=”left” title_text_color=”#000000″ title_font_size=”14px” global_colors_info=”{}”][\/et_pb_heading][et_pb_heading title=”k.karkali(at)cbm.csic.es” _builder_version=”4.27.7″ _module_preset=”default” title_level=”h5″ title_text_align=”left” title_text_color=”#000000″ title_font_size=”14px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#13B5BD” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_enable_image=”off” background_size=”custom” background_image_height=”84%” background_position=”bottom_right” custom_margin=”0px||0px||false|false” custom_padding=”0px||15px||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”40px||||false|false” custom_padding=”20px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Investigaci\u00f3n” module_id=”investiga” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

El comportamiento animal est\u00e1 determinado por la integraci\u00f3n de est\u00edmulos interoceptivos y exteroceptivos mediados por los circuitos neuronales del sistema nervioso central (SNC). Aunque actualmente se est\u00e1 dedicando un esfuerzo considerable a descifrar los conectomas de diferentes organismos, la contribuci\u00f3n de la organizaci\u00f3n estructural de los tejidos a su capacidad integradora ha sido relativamente poco estudiada. En este contexto, las redes gliales y la matriz extracelular (MEC) forman conjuntamente una unidad estructural din\u00e1mica e interdependiente que configura el SNC.<\/p>\n

As a Ram\u00f3n y Cajal Investigator at the CBM I study how the dynamic developmental interplay between glia and ECM contributes to CNS morphogenesis and function. To address this issue, I employ the Drosophila<\/em> embryonic CNS as a model system, focusing on the condensation of the Ventral Nerve Cord (VNC). Midway through embryogenesis, and simultaneously to neural circuits assembly into an array of interconnected neural modules, the VNC undergoes a dramatic condensation associated with the onset of motor coordination and embryo hatching. VNC condensation represents a novel model for investigating the relationship between structure and function, as it is highly sensitive to architectural changes and linked to a clear behavioral output: the embryo\u2019s ability to perform peristalsis and successfully hatch.<\/p>\n

Empleando la segmentaci\u00f3n de tejidos en 3D basada en FIB-SEM, microscop\u00eda confocal de alta resoluci\u00f3n y t\u00e9cnicas avanzadas de procesamiento de im\u00e1genes, persigo dos objetivos principales:<\/p>\n

1. Examinar c\u00f3mo se ensamblan las redes de gl\u00eda e interact\u00faan din\u00e1micamente con la MEC durante el desarrollo del SNC.<\/p>\n

2. Evaluar c\u00f3mo las propiedades materiales de la gl\u00eda y la MEC influyen en el equilibrio mec\u00e1nico del tejido y afectan al funcionamiento de los circuitos neuronales.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.04)” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Publicaciones representativas” module_id=”personal” _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”0px|||0px|false|false” custom_padding=”3px|||8px|false|false” border_width_left=”6px” border_color_left=”#34609B” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-1.jpg” title_text=”pub 1″ url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580722001678?via%3Dihub” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580722001678?via%3Dihub” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Condensation of the Drosophila<\/em> nerve cord is oscillatory and depends on coordinated mechanical interactions<\/h3>\n

Karkali, K. et al.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-2.png” title_text=”pub 2″ url=”https:\/\/www.nature.com\/articles\/s41467-023-36388-1″ url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.nature.com\/articles\/s41467-023-36388-1″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila<\/em>embryos<\/h3>\n

Karkali, K. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.23.4″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-3.png” title_text=”pub 3″ url=”https:\/\/www.nature.com\/articles\/s41467-023-43783-1″ url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.nature.com\/articles\/s41467-023-43783-1″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Puckered and JNK signaling in pioneer neurons coordinate the motor activity of the Drosophila<\/em> embryo<\/h3>\n

Karkali, K. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2026\/01\/pub-4.jpg” title_text=”pub 4″ url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266616672200781X?via%3Dihub” url_new_window=”on” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” link_option_url=”https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266616672200781X?via%3Dihub” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Measuring ventral nerve cord stiffness in live flat-dissected Drosophila<\/em> embryos by atomic force microscopy<\/h3>\n

Karkali, K. et al<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23.4″ _module_preset=”default” background_color=”#34609B” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Programas Cient\u00edficos” _builder_version=”4.25.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font_size=”26px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.25.0″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”0px|0px|0px|0px|false|true” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects1_sf.png” title_text=”areas_proyects1_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/dinamica-y-funcion-del-genoma\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects2_sf.png” title_text=”areas_proyects2_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects3_sf.png” title_text=”areas_proyects3_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/procesos-fisiologicos-y-patologicos\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/05\/areas_proyects4_sf.png” title_text=”areas_proyects4_sf” url=”https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/interacciones-con-el-entorno\/?lang=es” _builder_version=”4.25.0″ _module_preset=”default” animation_style=”zoom” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Programa Cient\u00edficoUNITS IN THIS PROGRAM Cell architecture and organogenesis Cell-cell communication and inflammationORCIDEl comportamiento animal est\u00e1 determinado por la integraci\u00f3n de est\u00edmulos interoceptivos y exteroceptivos mediados por los circuitos neuronales […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":283187,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-293644","page","type-page","status-publish","hentry"],"yoast_head":"\nMorfog\u00e9nesis del sistema nervioso central de Drosophila - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/programas-cientificos\/homeostasis-de-tejidos-y-organos\/arquitectura-celular-y-organogenesis\/morfogenesis-del-sistema-nervioso-central-de-drosophila\/?lang=es\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Morfog\u00e9nesis del sistema nervioso central de Drosophila - 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