{"id":287834,"date":"2024-11-25T17:12:45","date_gmt":"2024-11-25T16:12:45","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?p=287834"},"modified":"2024-11-28T16:18:16","modified_gmt":"2024-11-28T15:18:16","slug":"desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas","status":"publish","type":"post","link":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/","title":{"rendered":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas"},"content":{"rendered":"<p>Un equipo de investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM-CSIC-UAM) ha presentado un m\u00e9todo innovador y relativamente sencillo para medir con precisi\u00f3n la tasa de error de la transcriptasa inversa del virus VIH-1. Esta enzima produce ADN a partir de una plantilla de ARN, un proceso clave en la replicaci\u00f3n de retrovirus como el VIH. La tasa de error, o fidelidad, de una polimerasa como la transcriptasa inversa indica su capacidad para copiar \u00e1cidos nucleicos con precisi\u00f3n, siendo esto crucial para evitar mutaciones que pueden afectar a la estabilidad gen\u00e9tica o capacidad replicativa del virus. Este avance, basado en t\u00e9cnicas de secuenciaci\u00f3n masiva (<em>Next Generation Sequencing <\/em>o<em> NGS<\/em>), ofrece una alternativa m\u00e1s sencilla, econ\u00f3mica y precisa que los m\u00e9todos tradicionales, que suelen ser complejos y laboriosos.<\/p>\n<p>El estudio, recientemente publicado, destaca la implementaci\u00f3n de un ensayo de secuenciaci\u00f3n masiva, capaz de generar resultados robustos con un n\u00famero reducido de secuencias. Adem\u00e1s, por primera vez, los investigadores utilizaron una secuencia viral como plantilla para estimar las tasas de error de la transcriptasa inversa del VIH-1, evaluando par\u00e1metros t\u00e9cnicos fundamentales y utilizando ARN de diferentes or\u00edgenes.<\/p>\n<p>Los resultados son reveladores: la fidelidad de la transcriptasa inversa es ocho veces mayor cuando la s\u00edntesis de ADN se realiza a concentraciones de magnesio m\u00e1s bajas de las habituales. Esto coincide con estudios anteriores y subraya el impacto de las condiciones experimentales en la precisi\u00f3n de la enzima. Sorprendentemente, los investigadores tambi\u00e9n encontraron que las tasas de error de la transcriptasa inversa son similares para la misma secuencia de ARN, independientemente de si este ARN se ha obtenido sint\u00e9ticamente o a partir de c\u00e9lulas infectadas por el VIH.<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"wp-image-287837 aligncenter\" src=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-2.jpg\" alt=\"\" width=\"751\" height=\"500\" \/><\/p>\n<h6 style=\"text-align: center;\">Esquema que muestra la generaci\u00f3n de mutaciones en el proceso de retrotranscripci\u00f3n y posterior amplificaci\u00f3n por PCR, utilizado en los procedimientos de secuenciaci\u00f3n masiva \/ Luis Men\u00e9ndez Arias &amp; Javier Mart\u00ednez del R\u00edo<\/h6>\n<p>&nbsp;<\/p>\n<p>Este m\u00e9todo ofrece un avance significativo para el estudio de la fidelidad de polimerasas de retrovirus, con implicaciones importantes en transcript\u00f3mica, influyendo en la detecci\u00f3n de ARNs presentes en poca cantidad, as\u00ed como para la identificaci\u00f3n de modificaciones en el ARN. Adem\u00e1s, los resultados obtenidos podr\u00edan contribuir al desarrollo de enzimas mejoradas para diversas aplicaciones biotecnol\u00f3gicas.<\/p>\n<p>&#8220;Nuestro trabajo no solo aporta un enfoque nuevo, sino que tambi\u00e9n establece un marco para evaluar la fidelidad de enzimas retrovirales en distintos contextos&#8221;, se\u00f1ala Luis Men\u00e9ndez Arias, autor de correspondencia del estudio y director del grupo de investigaci\u00f3n \u201cRetrotranscriptasa del virus de la inmunodeficiencia humana y terapia antirretroviral\u201d en el CBM.<\/p>\n<p>Este avance promete beneficiar tanto a la investigaci\u00f3n b\u00e1sica como a aplicaciones biotecnol\u00f3gicas, marcando un paso importante en el desarrollo de herramientas para la mejora de tecnolog\u00edas basadas en transcriptasas inversas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Referencia<\/h3>\n<p>Mart\u00ednez Del R\u00edo J, Frutos-Beltr\u00e1n E, Sebasti\u00e1n-Mart\u00edn A, Lasala F, Yasukawa K, Delgado R, Men\u00e9ndez-Arias L. HIV-1 <strong>Reverse Transcriptase Error Rates and Transcriptional Thresholds Based on Single-strand Consensus Sequencing of Target RNA Derived From In Vitro-transcription and HIV-infected Cells.<\/strong> J Mol Biol. 2024 Nov 15;436(22):168815. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.jmb.2024.168815\">10.1016\/j.jmb.2024.168815<\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>Contacto<\/h3>\n<p>CBM Comunicaci\u00f3n: <a href=\"mailto:comunicacion@cbm.csic.es\">comunicacion@cbm.csic.es<\/a><\/p>\n<p>Luis Men\u00e9ndez Arias: <a href=\"mailto:lmenendez@cbm.csic.es\">lmenendez@cbm.csic.es<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equipo de investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM-CSIC-UAM) ha presentado un m\u00e9todo innovador y relativamente sencillo para medir con precisi\u00f3n la tasa de error de la [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":287835,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[44,54],"tags":[],"class_list":["post-287834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-scientific-article"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"og:description\" content=\"Un equipo de investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM-CSIC-UAM) ha presentado un m\u00e9todo innovador y relativamente sencillo para medir con precisi\u00f3n la tasa de error de la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Biolog\u00eda Molecular Severo Ochoa\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-25T16:12:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-28T15:18:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1604\" \/>\n\t<meta property=\"og:image:height\" content=\"1234\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Comunicaci\u00f3n CBM\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Comunicaci\u00f3n CBM\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/\"},\"author\":{\"name\":\"Comunicaci\u00f3n CBM\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/person\\\/402eebd24a9ee63c097c8c4b6d8d993f\"},\"headline\":\"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas\",\"datePublished\":\"2024-11-25T16:12:45+00:00\",\"dateModified\":\"2024-11-28T15:18:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/\"},\"wordCount\":583,\"publisher\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Imagen-1-2.png\",\"articleSection\":[\"News\",\"Scientific article\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/\",\"name\":\"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Imagen-1-2.png\",\"datePublished\":\"2024-11-25T16:12:45+00:00\",\"dateModified\":\"2024-11-28T15:18:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Imagen-1-2.png\",\"contentUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Imagen-1-2.png\",\"width\":1604,\"height\":1234},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/2024\\\/11\\\/25\\\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.cbm.uam.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#website\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"description\":\"Official website of the CBM, CSIC - UAM. Biomedical research centre.\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#organization\",\"name\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"contentUrl\":\"https:\\\/\\\/www.cbm.uam.es\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Logo-CBM-color-fondo-transparente.png\",\"width\":800,\"height\":342,\"caption\":\"Centro de Biolog\u00eda Molecular Severo Ochoa\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.cbm.uam.es\\\/?lang=es\\\/#\\\/schema\\\/person\\\/402eebd24a9ee63c097c8c4b6d8d993f\",\"name\":\"Comunicaci\u00f3n CBM\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g\",\"caption\":\"Comunicaci\u00f3n CBM\"},\"url\":\"https:\\\/\\\/www.cbm.uam.es\\\/index.php\\\/author\\\/comunicacion\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/","og_locale":"en_US","og_type":"article","og_title":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa","og_description":"Un equipo de investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM-CSIC-UAM) ha presentado un m\u00e9todo innovador y relativamente sencillo para medir con precisi\u00f3n la tasa de error de la [&hellip;]","og_url":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/","og_site_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","article_published_time":"2024-11-25T16:12:45+00:00","article_modified_time":"2024-11-28T15:18:16+00:00","og_image":[{"width":1604,"height":1234,"url":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png","type":"image\/png"}],"author":"Comunicaci\u00f3n CBM","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Comunicaci\u00f3n CBM","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#article","isPartOf":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/"},"author":{"name":"Comunicaci\u00f3n CBM","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/person\/402eebd24a9ee63c097c8c4b6d8d993f"},"headline":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas","datePublished":"2024-11-25T16:12:45+00:00","dateModified":"2024-11-28T15:18:16+00:00","mainEntityOfPage":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/"},"wordCount":583,"publisher":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization"},"image":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#primaryimage"},"thumbnailUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png","articleSection":["News","Scientific article"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/","url":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/","name":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas - Centro de Biolog\u00eda Molecular Severo Ochoa","isPartOf":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#primaryimage"},"image":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#primaryimage"},"thumbnailUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png","datePublished":"2024-11-25T16:12:45+00:00","dateModified":"2024-11-28T15:18:16+00:00","breadcrumb":{"@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#primaryimage","url":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png","contentUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Imagen-1-2.png","width":1604,"height":1234},{"@type":"BreadcrumbList","@id":"https:\/\/www.cbm.uam.es\/index.php\/2024\/11\/25\/desarrollan-un-metodo-novedoso-para-determinar-tasas-de-error-de-polimerasas-de-retrovirus-potentes-herramientas-biotecnologicas\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.cbm.uam.es\/"},{"@type":"ListItem","position":2,"name":"Desarrollan un m\u00e9todo novedoso para determinar tasas de error de polimerasas de retrovirus, potentes herramientas biotecnol\u00f3gicas"}]},{"@type":"WebSite","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#website","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","description":"Official website of the CBM, CSIC - UAM. Biomedical research centre.","publisher":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cbm.uam.es\/?lang=es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#organization","name":"Centro de Biolog\u00eda Molecular Severo Ochoa","url":"https:\/\/www.cbm.uam.es\/?lang=es\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/","url":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","contentUrl":"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2024\/11\/Logo-CBM-color-fondo-transparente.png","width":800,"height":342,"caption":"Centro de Biolog\u00eda Molecular Severo Ochoa"},"image":{"@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.cbm.uam.es\/?lang=es\/#\/schema\/person\/402eebd24a9ee63c097c8c4b6d8d993f","name":"Comunicaci\u00f3n CBM","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/de6b5676f8fd159f4954e2b189afeb8eb02394577af3fac160cf1d46d84862d7?s=96&d=mm&r=g","caption":"Comunicaci\u00f3n CBM"},"url":"https:\/\/www.cbm.uam.es\/index.php\/author\/comunicacion\/"}]}},"_links":{"self":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/posts\/287834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/comments?post=287834"}],"version-history":[{"count":0,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/posts\/287834\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/media\/287835"}],"wp:attachment":[{"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/media?parent=287834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/categories?post=287834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cbm.uam.es\/index.php\/wp-json\/wp\/v2\/tags?post=287834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}