{"id":291706,"date":"2025-09-11T10:00:54","date_gmt":"2025-09-11T08:00:54","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?p=291706"},"modified":"2025-09-10T16:04:52","modified_gmt":"2025-09-10T14:04:52","slug":"revelan-factores-clave-en-la-resistencia-al-dano-de-las-celulas-cancerosas","status":"publish","type":"post","link":"https:\/\/www.cbm.uam.es\/index.php\/2025\/09\/11\/revelan-factores-clave-en-la-resistencia-al-dano-de-las-celulas-cancerosas\/","title":{"rendered":"Revelan factores potencialmente clave en la resistencia al da\u00f1o de las c\u00e9lulas cancerosas"},"content":{"rendered":"<p>Un equipo del CABIMER (centro mixto CSIC-US-UPO-Junta de Andaluc\u00eda), ha identificado factores que amenazan la supervivencia de las c\u00e9lulas en ausencia de mecanismos de vigilancia del ciclo celular, como en el caso de los tumores. La investigaci\u00f3n ha revelado la capacidad de la prote\u00edna humana PrimPol, cuando es expresada en levaduras como organismos modelo, de prevenir la degradaci\u00f3n masiva del ADN que ocurre cuando fallan estos mecanismos de vigilancia, un proceso denominado <em>checkpoint<\/em>. Los resultados sugieren un posible papel para esta prote\u00edna en la supervivencia de las c\u00e9lulas tumorales, ya que estas acumulan mutaciones en el <em>checkpoint<\/em> que les permiten ser resistentes a tratamientos como la quimioterapia.<\/p>\n<p>El material gen\u00e9tico (ADN) ha de replicarse de manera eficiente y fidedigna en cada divisi\u00f3n celular. Este proceso es el periodo m\u00e1s vulnerable del ciclo celular, por tanto, es esencial identificar los factores que pueden alterarlo. Uno de los principales mecanismos de vigilancia del ciclo celular es el punto de control o <em>checkpoint<\/em> de replicaci\u00f3n, conservado por la evoluci\u00f3n desde levaduras hasta humanos. Este punto de vigilancia supervisa la correcta replicaci\u00f3n del ADN y, en caso de da\u00f1o, coordina los sistemas de reparaci\u00f3n, parando el ciclo celular. Cuando falla, la c\u00e9lula se vuelve especialmente vulnerable al da\u00f1o en el ADN, lo que conlleva consecuencias letales irreversibles.<\/p>\n<p>Publicado en la revista <em>Nucleic Acids Research<\/em>,\u00a0el trabajo, cuyo primer autor es<strong> Iv\u00e1n N\u00fa\u00f1ez Mart\u00edn<\/strong>, identifica adem\u00e1s tres factores espec\u00edficos (Rad51, Mus81 y Rad5) como responsables de esta toxicidad, utilizando la levadura como organismo modelo. Aunque normalmente ayudan a la progresi\u00f3n de la replicaci\u00f3n, estos mismos factores son responsables de la degradaci\u00f3n masiva del ADN reci\u00e9n sintetizado en c\u00e9lulas que carecen del sistema de vigilancia, como ocurre en la mayor\u00eda de las c\u00e9lulas cancer\u00edgenas.<\/p>\n<h6 style=\"text-align: center;\"><img decoding=\"async\" class=\"wp-image-291714 aligncenter\" src=\"https:\/\/www.cbm.uam.es\/wp-content\/uploads\/2025\/09\/20250910_100113-copy.jpg\" alt=\"\" width=\"728\" height=\"467\" \/><span lang=\"es\">Iv\u00e1n N\u00fa\u00f1ez Mart\u00edn<\/span><span style=\"color: #262626; font-family: Calibri, sans-serif;\">, primer autor del trabajo, junto a<\/span><span lang=\"es\">\u00a0<\/span><span lang=\"es\">Bel\u00e9n G\u00f3mez Gonz\u00e1lez<\/span><span lang=\"es\">, investigadora de la Universidad de Sevilla que ha liderado el proyecto<\/span><\/h6>\n<p>\u201cDado que las c\u00e9lulas cancerosas acumulan mutaciones en el <em>checkpoint<\/em> que les permiten tolerar la proliferaci\u00f3n celular descontrolada, estos hallazgos sugieren que la adquisici\u00f3n de mutaciones adicionales en factores como los identificados en este trabajo podr\u00edan ser responsables de quimioresistencia al promover la supervivencia al da\u00f1o\u201d, indica <strong>Bel\u00e9n G\u00f3mez Gonz\u00e1lez<\/strong>, investigadora de la Universidad de Sevilla (US) que ha liderado el proyecto.<\/p>\n<p>Esta investigaci\u00f3n se ha realizado en el grupo de Inestabilidad Gen\u00e9tica y C\u00e1ncer del investigador <strong>Andr\u00e9s Aguilera<\/strong> en CABIMER, en colaboraci\u00f3n con <strong>John Diffley<\/strong>, del Instituto Francis Crick de Londres (Reino Unido), y <strong>Luis Blanco<\/strong>, del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM-CSIC-UAM).<\/p>\n<p>&nbsp;<\/p>\n<h3>Referencia<\/h3>\n<p>Iv\u00e1n N\u00fa\u00f1ez-Mart\u00edn, Lucy\u00a0S Drury, Mar\u00eda\u00a0I Mart\u00ednez-Jim\u00e9nez, Luis Blanco, John\u00a0F X Diffley, Andr\u00e9s Aguilera, Bel\u00e9n G\u00f3mez-Gonz\u00e1lez, <strong>S-phase checkpoint protects from aberrant replication fork processing and degradation<\/strong>,\u00a0<em>Nucleic Acids Research<\/em>, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1093\/nar\/gkaf707\">10.1093\/nar\/gkaf707<\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>Contacto<\/h3>\n<p><strong>CBM-CSIC-UAM Comunicaci\u00f3n &#8211;\u00a0<\/strong><a href=\"mailto:comunicacion@csic.es\"><strong>comunicacion@csic.es<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equipo del CABIMER (centro mixto CSIC-US-UPO-Junta de Andaluc\u00eda), ha identificado factores que amenazan la supervivencia de las c\u00e9lulas en ausencia de mecanismos de vigilancia del ciclo celular, como en [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":291707,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[44,54],"tags":[],"class_list":["post-291706","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-scientific-article"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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