{"id":292059,"date":"2025-10-08T20:00:32","date_gmt":"2025-10-08T18:00:32","guid":{"rendered":"https:\/\/www.cbm.uam.es\/?p=292059"},"modified":"2025-10-09T13:33:04","modified_gmt":"2025-10-09T11:33:04","slug":"un-nuevo-hidrogel-en-spray-muestra-resultados-prometedores-para-prevenir-complicaciones-tras-la-cirugia-abdominal","status":"publish","type":"post","link":"https:\/\/www.cbm.uam.es\/index.php\/2025\/10\/08\/un-nuevo-hidrogel-en-spray-muestra-resultados-prometedores-para-prevenir-complicaciones-tras-la-cirugia-abdominal\/","title":{"rendered":"Un nuevo hidrogel en spray muestra resultados prometedores para prevenir complicaciones tras la cirug\u00eda abdominal"},"content":{"rendered":"

Investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM, CSIC-UAM), en colaboraci\u00f3n con Imperial College London, la Universidad de Oxford y la startup estadounidense TYBR Health, han demostrado en modelos animales que un innovador hidrogel en spray reduce de forma significativa la formaci\u00f3n de adhesiones peritoneales postquir\u00fargicas.<\/p>\n

Las adhesiones peritoneales<\/strong> son bandas de tejido cicatricial que se forman tras una cirug\u00eda abdominal y que pueden causar dolor cr\u00f3nico, obstrucci\u00f3n intestinal o infertilidad. Actualmente no existe ninguna medida eficaz para prevenirlas, y la \u00fanica opci\u00f3n terap\u00e9utica es volver a operar al paciente.<\/p>\n

El nuevo hidrogel, desarrollado por TYBR Health, se aplica en forma de aerosol durante la cirug\u00eda. Est\u00e1 compuesto de matriz extracelular de origen porcino<\/strong> y presenta propiedades inteligentes: es l\u00edquido a baja temperatura, lo que facilita su aplicaci\u00f3n, y al alcanzar la temperatura corporal se convierte en un gel que permanece en el lugar de la intervenci\u00f3n.<\/p>\n

Adem\u00e1s de funcionar como una barrera f\u00edsica que evita que los \u00f3rganos se adhieran entre s\u00ed, el hidrogel act\u00faa como modulador biol\u00f3gico<\/strong>. Protege al tejido de se\u00f1ales mec\u00e1nicas e inflamatorias y bloquea un proceso celular clave \u2013la transici\u00f3n mesotelio-mesenquimal<\/strong>\u2013 que convierte c\u00e9lulas protectoras del peritoneo en fibroblastos, responsables de la fibrosis y las adherencias.<\/p>\n

Los ensayos realizados en ratones y conejos sometidos a cirug\u00edas abdominales mostraron que el hidrogel favorece la regeneraci\u00f3n del mesotelio y reduce de forma notable la aparici\u00f3n de adherencias, demostrando un perfil de biocompatibilidad y eficacia muy superior a las estrategias actuales.<\/p>\n

\u201cSe trata de un enfoque innovador y cl\u00ednicamente transferible que podr\u00eda mejorar la recuperaci\u00f3n de millones de pacientes sometidos a cirug\u00eda abdominal en todo el mundo\u201d, explica la Dra. Pilar Sandoval, investigadora del CBM.<\/p>\n

Los resultados posicionan a este hidrogel como una estrategia prometedora para prevenir complicaciones postquir\u00fargicas<\/strong>, con un impacto potencial tanto en la calidad de vida de los pacientes como en la reducci\u00f3n de la carga para los sistemas sanitarios.<\/p>\n

 <\/p>\n

Referencia<\/h3>\n
Luc\u00eda Pascual-Ant\u00f3n, Pilar Sandoval,\u00a0et al.\u00a0<\/em><\/span>Sprayable extracellular matrix hydrogel reduces postoperative adhesion formation and protects healing tissues in preclinical models.<\/span>Sci. Transl. Med.<\/i><\/span>17<\/b>,<\/span>eadn3179<\/span>(2025).<\/span>DOI:10.1126\/scitranslmed.adn3179<\/a><\/span><\/div>\n
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Investigadores del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM, CSIC-UAM), en colaboraci\u00f3n con Imperial College London, la Universidad de Oxford y la startup estadounidense TYBR Health, han demostrado en modelos […]<\/p>\n","protected":false},"author":3,"featured_media":292063,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[44,54],"tags":[],"class_list":["post-292059","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-scientific-article"],"yoast_head":"\nUn nuevo hidrogel en spray muestra resultados prometedores para prevenir complicaciones tras la cirug\u00eda abdominal - Centro de Biolog\u00eda Molecular Severo Ochoa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbm.uam.es\/index.php\/2025\/10\/08\/un-nuevo-hidrogel-en-spray-muestra-resultados-prometedores-para-prevenir-complicaciones-tras-la-cirugia-abdominal\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nuevo hidrogel en spray muestra resultados prometedores para prevenir complicaciones tras la cirug\u00eda abdominal - 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