Scientific facilities

Preclinical biomedicine

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Facility Head

Blanca Estévez Santiago

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Scientific Lead

Konstantinos Stamatakis Adriani

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Contact details

91 196 45 77

biomedicina.preclinica (at) cbm.csic.es

Preclinical biomedicine is a scientific facility inaugurated in 2024, located in the animal facility of the CBM, which offers advice and scientific-technical support for the experimental design and use of experimental equipment with mice.

We aim to provide high-quality and reliable services that meet the needs and expectations of the researchers, as well as the ethical and regulatory standards for animal research. The service is open to all researchers from the institute and external collaborators who are interested in using the equipment.

The facility provides training and guidance on how to use the equipment, as well as advice on data analysis and interpretation. The service staff is experienced and qualified in the field of preclinical biomedicine and can assist investigators with their experimental design and execution.

The equipment offered by this facility is described below:

Vacío

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Metabolic cages for mice

PhenoMaster Metabolic Cages from TSE Systems and Comprehensive Lab Animal Monitoring System, CLAMS, for analysis: These cages allow measurement of various metabolic parameters of mice, such as food and water intake, energy expenditure, movement, temperature, body weight and oxygen expenditure. There is space to house 12 mice individually.

Mouse endoscope

COLOVIEW Mainz from Karl Storz: This device allows visualization of the colon, fluid injection and color video recording in anesthetized mice.

In vivo imaging systems

IVIS Lumina II and IVIS Spectrum: These systems allow the non-invasive imaging of living animals using different modalities, such as optical, fluorescence and bioluminescence.

 

Element HT5 hemocytometer

A multichannel analyzer that uses laser flow cytometry, impedance technology and colorimetric detection to quickly and accurately determine a complete 20-parameter hematological profile in less than one minute, using only 15 µL of whole blood. It also allows safe analysis of various cavitary fluids other than blood with immediate information on their cellular content.

Accurate sample measurement results are displayed both numerically and in the form of WBC scatter plots and WBC/PLT histograms.

Biochemical analyzer

Vetscan VS2: chemical, gasometric and electrolytic analyzer that performs multi-chemical blood analysis in 12 minutes with accurate results and with only 100 microliters of blood. It has a sophisticated intelligent quality control (iQC®) system that guarantees quality and reliable results. VETSCAN VS2 profiles are conveniently packaged as single-use rotors and each reagent rotor contains a diluent and all the tests needed to perform a complete multi-chemistry blood test, with different values depending on the rotor chosen:

  • Comprehensive Diagnostic Profile: The Comprehensive Diagnostic Profile is ideal for providing a complete chemistry and electrolyte analysis.
    ALB, ALP, ALT, AMY, BUN, Ca, CRE,GLOB, GLU, K+, Na+, PHOS, TBIL, TP
  • Preventive Care Profile Plus: The Preventive Care Profile Plus is ideal for providing a complete chemistry and complete electrolyte analysis
    ALB, ALP, ALT, AST, BUN, Ca, Cl- , CRE, GLOB, GLU, K+, Na+, TBIL, tCO2, TP
  • Electrolytes Plus: Electrolyte Plus is ideal for the regulation of acid/base and osmotic balance
    Cl- ,K+ ,Na+ , tCO2
  • Prep Profile II: Prep Profile II is ideal for a health assessment.
    ALP, ALT, BUN, CRE, GLU, TP
  • Critical Care Plus: Critical Care Plus is ideal for serial testing, re-evaluations
    ALT, BUN, Cl-, CRE, GLU, K+ ,Na+ ,tCO2
  • Kidney Profile Plus: Kidney Profile Plus is ideal for performing kidney assessment and monitoring
    ALB, BUN, Ca, Cl-, CRE, GLU, K+ ,Na+ ,PHOS, tCO2
  • Mammalian Liver Profile: The Mammalian Liver Profile is ideal for obtaining reference liver values.
    ALB, ALP, ALT, BA, BA, BUN, CHOL, GGT, TBIL
  • Phenobarbital Profile: The Phenobarbital Profile is a cost-effective rotor that assesses phenobarbital level and provides additional liver values, all in one panel.
    ALB, ALP, ALT, ALT, AST, BUN, GGT, PHB, TBIL
  • T4/Cholesterol Profile: The T4/Cholesterol profile is ideal for routine screening of hypothyroidism and diagnosis of hyperthyroidism.

T4, CHOL

Stereoscopic Microscope

IVESTA 3 Greenough Stereoscopic Microscope.

Unlike conventional stereoscopic microscopes, Ivesta 3 features FusionOptics technology, which combines high resolution and great focal length, all at the same time.

It has its own software that can be downloaded to make easier to use the images on laptop and smartphone.