Our research group investigates the mechanisms that control adult hippocampal neurogenesis, both under physiological and pathological conditions. We perform in vivo and in vitro studies animal models of different diseases, and also use human brain samples. In particular, we are interested in determining the therapeutic potential of increasing adult hippocampal neurogenesis for the treatment of neurodegenerative diseases such as Alzheimer´s disease (AD), Huntington´s disease, Parkinson´s disease, or ALS, and psychiatric conditions. The hippocampus plays a pivotal role in learning and memory. Furthermore, a unique feature of this structure is the existence of adult neurogenesis. The process of adult hippocampal neurogenesis encompasses the birth and functional integration of newborn neurons throughout lifetime. Adult hippocampal circuit confers and extraordinary degree of plasticity to the circuit. Thus, we work to develop strategies capable of increasing the functionality of newborn neurons.