Scientific Program
Tissue and organ homeostasis
RESEARCH GROUP
Immunometabolism and inflammation
María Mittelbrunn
We aspire to rejuvenate the immune system using cutting-edge nutritional, genetic, cellular, and pharmacological strategies, aiming to prevent chronic inflammation and age-related diseases, thereby redefining the concept of healthy aging.
Research
We have been pioneers proposing that the immune system, particularly T cells, controls tissue senescence and the onset of age-related diseases. We are now investigating how the immune system contributes to systemic senescence as well as to the general aging process. Would the rejuvenation of the immune system compartment suffice to delay organismal aging or at least some of its manifestations? An affirmative response to this question might have vast consequences for improving healthy aging.
Projects
Group members
Enrique Gabandé Rodríguez
Lab.: 126 Ext.: 4529
egabande(at)cbm.csic.es
Eva María Blanco Ruíz
Lab.: 126 Ext.: 4529
eblanco(at)cbm.csic.es
María Mittelbrum Herrero
Lab.: 126 Ext.: 4528
mmittelbrunn(at)cbm.csic.es
Manuel Montero Gómez de las Heras
Lab.: 126 Ext.: 4529
manuel.montero(at)cbm.csic.es
Elisa Carrasco Cerro
Lab.: 126 Ext.: 4529
elisa.carrasco(at)cbm.csic.es
Mario Pérez Manrique
Lab.: 126 Ext.: 4529
mario.perez(at)cbm.csic.es
José Ignacio Escrig Larena
Lab.: 126 Ext.: 4529
jiescrig(at)cbm.csic.es
Isaac Francos Quijorna
Lab.: 126 Ext.: 4529
isaac.francos(at)cbm.csic.es
Álvaro Fernández Almeida
Lab.: 126 Ext.: 4529
alvaro.fernandez(at)cbm.csic.es
Sandra Delgado Pulido
Lab.: 126 Ext.: 4529
sdelgado(at)cbm.csic.es
Marta Villar Castillo
Lab.: 126 Ext.: 4529
marta.villar(at)cbm.csic.es
Carolina P. Villarroya Beltri
Lab.: 126 Ext.: 4529
cvillarroya(at)cbm.csic.es
Pablo Ramirez Ruiz de Erenchun
Lab.: 126 Ext.: 4528
Marta Arjona Blanco
Lab.: 126 Ext.: 4529
Alice Leandri
Lab.: 126 Ext.: 4528
Selected publications
Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Enrique Gabandé-Rodríguez et al.
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
Gabriela Desdín-Micó et al.
The role of T cells in age-related diseases
Elisa Carrasco et al.
Hallmarks of T cell aging
Maria Mittelbrunn et al.
Latest publications
Scientific Programs
