Predoctoral Contract at the CBM – Molecular and Translational Research in Vascular Pathologies Group (Juan Miguel Redondo’s Laboratory)

We are offering a predoctoral position in our group to study the molecular mechanisms driving aortic diseases, particularly familial forms of thoracic aortic aneurysm and dissection (TAAD). Our research focuses on identifying key mediators involved in the pathogenesis of Marfan and Loeys-Dietz syndromes. We use advanced imaging, omics technologies, biochemical and genetic approaches in both mouse models and patient samples to discover risk biomarkers and therapeutic targets.

Candidate Profile

We are seeking a highly motivated individual interested in starting a scientific career and pursuing a PhD within our team. Applicants must have completed a Master’s degree in Biomedicine or a related field by September 2025 at the latest and have a Grade Point Average above 8/10 in their academic record.

The ideal candidate will demonstrate initiative and creativity in formulating hypotheses and solving problems, as well as a proactive attitude toward scientific and experimental challenges. We value openness to continuous learning, strong organizational and communication skills, self-criticism, scientific rigor, and a solid work ethic.

We offer the opportunity to join our team through a predoctoral contract linked to the project aimed at advancing the understanding and treatment of aortic aneurysms in Marfan and Loeys-Dietz syndromes.

Selected Publications from the Last 10 Years:

·              Yunes-Leites PS, et al. Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension. PLoS Biol. 2025

·              Gómez-Del Arco P, et al. The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024

·              Ruíz-Rodríguez MJ, et al. Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation. EMBO Mol Med. 2024

·              Toral M, et al. The Nitric Oxide Signalling Pathway in Aortic Aneurysm and Dissection. Br J Pharmacol. 2021

·              de la Fuente-Alonso A, et al. Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO. Nat Commun. 2021

·              Alfranca A, et al. New Methods for Disease Modeling Using Lentiviral Vectors. Trends Mol Med. 2018

·              Villahoz S, et al. Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Nat Commun. 2018

·              de Cárcer G, et al. Plk regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat Med. 2017

·              Oller J, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017

·              Gómez-Del Arco P, et al. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016

More information about our group’s research activities is available on our website:
https://www.cbm.uam.es/jmredondo