PhD contract: Unraveling TCR Signaling Architecture for Next-Generation Bispecific T-cell Engagers (TCR4BiTEs)

We offer a 4-year predoctoral contract* to join the laboratory of Prof. Balbino Alarcón at the Centro de Biología Molecular Severo Ochoa (CBM) in Madrid, Spain, aimed at investigating the earliest events in signal transduction by the T cell antigen receptor (TCR) and strategies to modulate its signaling in order to selectively inhibit T cell involvement in autoimmune diseases such as psoriasis, multiple sclerosis, rheumatoid arthritis or diabetes, while allowing the formation of a robust immune response against viral and microbial pathogens.

In addition, the project aims at studying the molecular mechanisms of T cell help to B cell during the maturation of the humoral response that allows the generation of high-affinity mature immunoglobulins of diagnostic and therapeutic interest. The laboratory also has an interest in exploring the relevance of the RAS-related GTPase R-RAS2 in human cancer. The estimated start date is in January-February 2027.

*Financed with grant PID2025-167743OB-I00 funded by MCIN/AEI.

Requirements

-Graduated in Biochemistry, Biology, Medicine, Pharmacy or related areas, with master studies already finalized.

How to apply

Candidates please send a CV and a motivation letter to Prof Balbino Alarcon (balarcon@cbm.csic.es) no later than the 22nd of September 2026.