One of the most exciting aspects of our biology is the fact that all our cells share the same genetic information (handbook). The differential reading of this info is key to generate the diversity of cell types during the developmental program of a complex organism. In this frame, the transcription of DNA into RNA constitutes the first stage of that reading and is essential to establish differential gene expression patterns defining the distinct cell lineages. In addition to transcription, the process of mitosis is fundamental to obtain the precise number of cells to build a whole organism while the establishment of most of the cell lineages required the passage of cells through mitosis. Interestingly, transcription is widely silenced during mitosis due the release of RNA polymerases and transcription factors from the condensing chromatin. Once mitosis ends, transcription restart immediately to guarantee the viability and identity of daughter cells. The mechanisms behind transcription restart following mitosis are poorly understood. How daughter cells remember the transcriptional program of the mother or/and how those programs rewire during development are mostly unknown. In our laboratory we aim to answer these questions using the culture of mammalian cells as a model.