CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA
Investigadores del Centro de Biología Molecular Severo Ochoa (CBMSO), UAM/CSIC, y del CIBERCV han descubierto un nuevo mecanismo de detección de nutrientes para modular la autofagia
El grupo de María Llorens, investigadora del CBM, demuestra la existencia de células madre en el hipocampo, que permiten producir neuronas durante toda la vida. Los resultados se han publicado en la revista Science. DOI: 10.1126/science.abl5163
https://www.fbbva.es/equipo/microordesa-microorganismos-y-virus-en-el-parque-nacional-de-ordesa-y-monte-perdido/
El Grupo de José M. Almendral, ha demostrado en modelos de ratón la utilidad de los virus oncolíticos, o virus anti-cáncer, capaces de infectar y destruir células madre malignas de tumores cerebrales humanos. Los resultados se publican en Cell Reports.
El equipo liderado por José Javier Lucas del CBM ha identificado una nueva diana terapéutica para la enfermedad de Huntington, una patología hereditaria que provoca la degradación progresiva o degeneración de las células nerviosas del cerebro.
23 Ciclo de Webinars/Seminars Severo Ochoa. Curso 2021/2022
Investigadores del CBM descubren un nuevo mecanismo para potenciar la secreción de insulina
Investigadores del CBMSO y del CABD, emplean técnicas de secuenciación masiva para caracterizar el programa genético que regula la formación del ojo en el embrión. Los resultados, publicados en la revista Nature Communication, son relevantes para optimizar los protocolos de obtención de células de remplazo, empleadas en terapia celular paliativa para las enfermedades neurodegenerativas del ojo.
El investigador, C. Toma del CBMSO, participa en el mayor estudio genómico en trastorno bipolar realizado hasta la fecha que ha permitido identificar 64 regiones del genoma asociadas con esta condición. Este estudio, publicado en Nature Genetics, ha involucrado a más de 450.000 participantes, de los cuales 40.000 con trastorno bipolar. Sus resultados permitirán avanzar a un mejor diagnostico y tratamiento de las personas que desarrolla este trastorno.
El grupo del CBMSO dirigido por María Yáñez-Mó, en colaboración con Héctor Peinado en el CNIO, ha demostrado que la ruta de formación de exosomas está íntimamente ligada al control de calidad de las mitocondrias, afectando así al metabolismo y crecimiento celular. Sus resultados muestran que tratamientos que bloquean la función de la proteína de exosomas CD9, reducen el crecimiento de células de melanoma en modelos animales.
Investigadores del Centro de Biología Molecular Severo Ochoa (UAM-CSIC) han publicado un trabajo en la revista “Aging US” en el que describen un mecanismo molecular que gobierna el envejecimiento en células eucarióticas. El envejecimiento celular está asociado a la acumulación de proteínas incorrectamente plegadas. Los defectos en los mecanismos de plegamiento o degradación de proteínas incorrectamente plegadas, aceleran el envejecimiento. En este trabajo se demuestra que la traducción, mecanismo por el que se producen estas proteínas, también es clave en la aceleración o retraso del envejecimiento.

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23 Nov
2021

12:00h
23 Severo Ochoa Seminar Cycle In honor to Eladio Viñuela - PRESENTIAL -

Title: Regulation Of Replication Timing And Chromosome Architecture

Speaker: David M. Gilbert (Biological Sciencie, Florida State University. USA)

Host: María Gómez

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24 Nov
2021

10:00h
Seminar Program 4 - Interactions with the Environment

Unit: Microbes in health and welfare

Title: Directed evolution and rational design approaches for the thermostabilisation of an industrially relevant aldolase

Speaker: Sandra Bosch Reñé

Grupo: Aurelio Hidalgo

Internal Seminar

25 Nov
2021

12:00h
Special Seminar    - PRESENTIAL -

Title: Mathematical approaches to RNA virus dynamics and evolution

Speaker: Josep Sardanyés Cayuela (Nonlinear Dynamics and Evolution (NoDE) Lab (Mathematical Biology Group). Centre de Recerca Matemàtica, Barcelona)

Host: Esteban Domingo

Place: Sala Ramón Areces CBM

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26 Nov
2021

12:00h
23 Severo Ochoa Seminar Cycle "Advances in Molecular Biology" - ONLINE -

Title: Fumarate hydratase loss as a paradigm of oncometabolism

Speaker: Christian Frezza (MRC Cancer Unit, University of Cambridge. Cambridge, UK,/ University of Cologne, CECAD, Cologne Germany )

Host: Eduardo Balsa

Connection link: webinar.cbmso.es

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Santander Fondo Solidario Juntos

El Banco Santander ha realizado una donación a la FSO para apoyar la investigación relativa a COVID-19 en el CBMSO, en el marco del "Fondo Solidario Juntos" que han creado para contribuir a la lucha contra la pandemia.

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