Preclinical imagen of small animals

Technical director: Núria Gironès

  ngirones (at) cbm.csic.es
  Second floor - 226

El laboratorio RedLab de imagen óptica BIOLUMLAB, tiene como misión principal ofrecer asesoramiento y consultoría científico-experimental en imagen óptica preclinica de modelos animales, así como la ejecución de dichos experimentos, y el análisis e interpretación de los datos de imagen generados durante los mismos.

Para llevar a cabo nuestro principal objetivo, contamos con un equipo de bioluminiscencia y fluorescencia (IVIS Lumina II, Caliper Life Sciences). Este equipo permite realizar adquisiciones de imágenes seriadas, a tiempo real, y de manera no invasiva en modelos establecidos de animales de laboratorio para enfermedades inflamatorias, cardiovasculares y oncológicas, así como modelos de infección bacteriana, enfermedades autoinmunes (Chagas), y parásitos (Leishmania spp.).

Adicionalmente, proporcionamos un servicio de análisis de las imágenes obtenidas durante el proceso experimental con software especializado, incluyendo cuantificación de sondas fluorescentes y localización anatómica de la señal óptica.

Este servicio también dispone de un equipo Lector de Microplacas Multifuncional (FLUOstar OPTIMA, BMG LABTECH), que realiza lecturas de la intensidad de fluorescencia en tiempo real, absorbancia y luminiscencia.

Recientemente hemos incorporado al servicio un endoscopio para ratones y ratas (Coloview Mainz, Karl Storz), idóneo para estudios en modelos de inflamación intestinal y de cáncer de colon que permite acceso directo y continuado por video al colon de un animal vivo.

En el RedLab Biolumlab estamos abiertos a colaboraciones y proyectos innovadores y creativos en el ámbito de la imagen óptica preclinica.

En principio este servicio es gratuito para los miembros del Programa de INFLAMUNE-CM S-2017/BMD-3671, así como para el personal del Centro de Biología Molecular “Severo Ochoa”.

En caso de no pertenecer a estos organismos se pedirá información detallada del ensayo que se entregará a los comités de animalario y de ética para su estudio. En caso de aprobación se enviará un presupuesto

Al inicio del proyecto se dará de alta en el sistema de reservas online.

Algunas instituciones que utilizan nuestros servicios

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El LabRed BIOLUMLAB pertenece y está financiado por la Red de Laboratorios e Infraesturas de la Comunidad de Madrid dentro del Programa INFLAMUNE-CM S-2017/BMD-3671 PROGRAMA DE ACTIVIDADES I+D EN BIOMEDICINA entre Grupos de la COMUNIDAD DE MADRID

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* For external calls please dial 34 91196 followed by the extension number
Last name Name Laboratory Ext.* e-mail Professional category
Gironès Pujol Núria 226 4593 ngirones(at)cbm.csic.es Profesor Titular Universidad, GA
Equipos
...
IVIS LUMINA II (Caliper Life Sciences)

Ubicación: Sala 49-P2 Animalario (planta sótano -1)

Datos de los ensayos:

  • Biológicos
  • Animales (ratón y rata)
  • Determinación de bioluminiscencia y fluorescencia en tumores y micoroorganismos patógenos
  • Imagen óptica

Datos del equipo:

  • Equipo de imagen óptica por bioluminiscencia y fluorescencia (IVIS Lumina)
  • Bioluminiscencia y fluorescencia con rango de detección hasta un nivel celular
  • Ensayos biológicos en modelos animales para imagen preclínica
...
FLUOstar OPTIMA (BMG LABTECH)

Ubicación: Sala 255 (planta 2)

Datos de los ensayos:

  • Biológicos
  • Cultivos celulares y fluidos biológicos
  • Medición de absorvancia UV/Vis
  • Medición de fluorescencia
  • Cuantificación de macromoléculas

Datos del equipo:

  • Espectrofotómetro/fluorímetro FluoStar Optima
  • Lector de microplacas multimodo para absorvancia UV/Vis y lfuorescencia
  • Cultivos y sobrenadantes celulares y fluidos biológicos
...
Sistema COLOVIEW Mainz
Set para colonoscopias en ratones y ratas

Ubicación: Sala 55 - P2 Animalario (planta -1)

Datos de los ensayos:

  • Biológicos
  • Animales (ratón y rata)
  • Determinación de alteraciones en la organización del colon
  • Imagen óptica

Datos del equipo:

  • Equipo de imagen óptica (COLOVIEW Mainz)
  • Ensayos biológicos en modelos animales para imagen preclínica
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