CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA

Jobs Opportunities

 

 

Job Offers - CBM Research Groups
 
Call for postdoctoral contract: Titulado Superior      

Biomecánica y dinámica de virus humanos para el desarrollo de fármacos antivirales y materiales modificados por ingeniería de proteínas

El tema de investigación a realizar está relacionado con la ingeniería y análisis molecular de virus para el desarrollo de aplicaciones biomédicas o nanotecnológicas.

 
Master Degree  

Deciphering how B cell metabolism shapes Germinal Centrshutdown and its relation with immune system disorders

Deciphering molecular mechanisms controlling Germinal Centre (GC) initiation has attracted the attention of immunologists in the last decade, aiming to understand the stepwise immune response and improve vaccination strategies. However, while a deficient GC initiation can lead to immunodeficiencies, an overactivation of GC can lead to GC-derived lymphomas or autoimmune diseases. Therefore, in addition to GC initiation, the processes leading to the GC reaction and termination of the cellular expansion are also of high scientific and clinical interest. However, the mechanisms for this GC shutdown have been disregarded until now. In our laboratory, we have preliminary results showing that a specific metabolic profile in B lymphocytes triggers the GC shutdown. We are seeking a highly motivated and talented candidate interested in developing a thesis project focused on identifying the metabolic processes that trigger the GC shutdown. The candidate will have to analyze integrative ‘omics’, using mainly RNA-seq, ATAC-seq, metabolomics and proteomics sets of data generated in our laboratory or publicly available in different databases. We offer a fully funded position starting in December 2022 in an excellent and stimulating scientific environment in the CBMSO (Madrid).

 
Call for postdoctoral contract     

Deciphering how B cell metabolism shapes Germinal Centrshutdown and its relation with immune system disorders

Deciphering molecular mechanisms controlling Germinal Centre (GC) initiation has attracted the attention of immunologists in the last decade, aiming to understand the stepwise immune response and improve vaccination strategies. However, while a deficient GC initiation can lead to immunodeficiencies, an overactivation of GC can lead to GC-derived lymphomas or autoimmune diseases. Therefore, in addition to GC initiation, the processes leading to the GC reaction and termination of the cellular expansion are also of high scientific and clinical interest. However, the mechanisms for this GC shutdown have been disregarded until now. In our laboratory, we have preliminary results showing that a specific metabolic profile in B lymphocytes triggers the GC shutdown. We
seek a highly motivated and talented candidate interested in developing a project focused on identifying the metabolic processes that trigger the GC shutdown. The candidate will have to analyze integrative ‘omics’, using mainly RNA-seq, ATAC-seq, metabolomics and proteomics sets of data generated iour laboratory or publicly available in different databases. We offer postdoctoral fully funded position starting in December 2022 in an excellent and stimulating scientific environment in the CBMSO (Madrid). The salary will be commensurated with expertise and qualifications.

 
Ayudante de Investigación     

Mecanismos moleculares de las diferencias sexuales en la fisiología y en las enfermedades del metabolismo

El/la candidata/a será integrado en un estudio sobre las diferencias sexuales mitocondriales y así descifrar su papel en el metabolismo de la glucosa

 
Ayudante de Investigación     

Citrin and Aralar: Role in liver and brain metabolism

We are looking for two highly motivated canditates to start a thesis on mitochondrial metabolism. The candidates will join a proyect to characterize the role of the aspartate-glutamate carriers in different aspects of liver and brain metabolism and their impact on human health, through the use of transgenic mouse models and in vitro models. The contracts, funded by the “Programa Investigo de la CAM 2022 (Posts offers #32 and #75)”, will be carried out at the CBMSO with the supervision of Dr. Beatriz Pardo and Dr. Laura Contreras.

 
Call for postdoctoral contract: Titulado Superior      

Proteolytic activation of lysyl oxidases: Biotechnological applications and contribution to extracellular matrix remodeling in the development of human diseases

Analysis of the mechanisms governing the remodeling of the extracellular matrix, with particular focus on the regulation of the expression and activity of matrix-crosslinking enzymes of the lysyl oxidase (LOX) family

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