Functional organization of the mammalian genome
Research summary:
Copying and decoding the genomic information in a timely and accurate fashion is essential for life. Both tasks (DNA replication and transcription) are remarkably complex in scale and regulation, and the molecular machineries involved in them translocate on the same substrate, the chromatin. The general aim of our laboratory is understanding how the processes of DNA replication and transcription are coordinated in mammalian cells to maintain genome stability. This knowledge is fundamental for basic biology and have enormous implications for cell fate specification in physiology and pathology.
To investigate this we combine the application of genomics, epigenomics, epitranscriptomics, molecular biology and imaging techniques to a variety of cell scenarios with altered chromatin structure and/or transcription dysregulation.
Some of the questions we try to address:
If you are an enthusiastic scientists interested in investigating genome´s functionality and want to join our team, please send an updated cv and motivation letter to María Gómez (mgomez@cbm.csic.es).
Our lab participates in the Horizon Europe Marie Sklodowska-Curie Doctoral Network “RepliFate” (GA101072903)
| Last name | Name | Laboratory | Ext.* | Professional category | |
|---|---|---|---|---|---|
| Gallego Jiménez | Alicia | 405 | 4469 | agallego(at)cbm.csic.es | M2 |
| García Ordóñez | Carlos | 405 | 4702 | Becario JAE Intro | |
| Gómez Vicentefranqueira | María | 405 | 4724/4702 | mgomez(at)cbm.csic.es | E.Científicos Titulares de Organismos Públicos de Investigación |
| Isoler Alcaraz | Javier | 405 | 4702 | jisoler(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
| Segura Martínez | Joana | 405 | 4702 | joana.segura(at)cbm.csic.es | Titulado Superior Grado de Doctor |
| Tong | Ran | 405 | 4724 | ran.tong(at)cbm.csic.es | M3 Predoc.formación |
| Tur Gracia | Sara | 405 | 4724/4702 | sara.tur(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
Relevant publications:
- Jodkowska K, Pancaldi V, Almeida R, Rigau M, Graña O, Fernández-Justel JM, Rodríguez-Acebes S, Rubio-Camarillo M, Carrillo-de Santa Pau E, Pisano D, Al-Sharour F, Valencia A, *Gómez M and *Méndez J. 2019. Three-dimensional connectivity and chromatin environment mediate the stochastic activation of stress-responsive DNA replication origins. BioRxiv 644971 doi:10.1101/644971 *CO-CORRESPONDING AUTHORS
- Almeida, R., Fernández-Justel, J. M., Santa-María, C., Cadoret, J. C., Cano-Aroca, L., Lombraña, R., Herranz, G., Agresti, A. and Gómez, M. 2018. Chromatin conformation regulates the coordination between DNA replication and transcription. Nat Commun, 9:1590. PUBLICACIÓN RECOMENDADA EN FACULTY OF 1000
- Lombraña, R., Álvarez, A., Fernández-Justel, J. M., Almeida, R., Poza-Carrión, C., Gomes, F., Calzada, A., Requena, J. M. and Gómez, M. 2016. Transcriptionally driven DNA replication programme of the human parasite Leishmania major. Cell Rep, 16: 1-13.
- Lombraña, R., Almeida, R., Revuelta, I., Madeira, S., Herranz, G., Saiz, N., Bastolla, U. and Gómez, M. 2013. High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins. EMBO J. 32: 2631-2644.
