CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOACaptura de pantalla 2022 09 14 a las 10.27.10    

Functional organization of the mammalian genome

Research summary:

Copying and decoding the genomic information in a timely and accurate fashion is essential for life. Both tasks (DNA replication and transcription) are remarkably complex in scale and regulation, and the molecular machineries involved in them translocate on the same substrate, the chromatin. The general aim of our laboratory is understanding how the processes of DNA replication and transcription are coordinated in mammalian cells to maintain genome stability. This knowledge is fundamental for basic biology and have enormous implications for cell fate specification in physiology and pathology.

To investigate this we combine the application of genomics, epigenomics, epitranscriptomics, molecular biology and imaging techniques to a variety of cell scenarios with altered chromatin structure and/or transcription dysregulation.


Some of the questions we try to address:


If you are an enthusiastic scientists interested in investigating genome´s functionality and want to join our team, please send an updated cv and motivation letter to María Gómez (mgomez@cbm.csic.es).

Our lab participates in the Horizon Europe Marie Sklodowska-Curie Doctoral Network “RepliFate” (GA101072903)






* For external calls please dial 34 91196 followed by the extension number
Last nameNameLaboratoryExt.*e-mailProfessional category
Gallego JiménezAlicia4054469agallego(at)cbm.csic.esM2
Gómez VicentefranqueiraMaría4054724/4702mgomez(at)cbm.csic.esE.Científicos Titulares de Organismos Públicos de Investigación
Isoler AlcarazJavier4054702jisoler(at)cbm.csic.esTitulado Sup. Actividades Tecn. y Prof.GP1
Martín VírgalaSara4054702sara.martin(at)cbm.csic.esM2 66,66%
Rus MorenoAdrián de4054702adrian.derus(at)cbm.csic.esM3 Predoc.formación
Segura MartínezJoana4054702joana.segura(at)cbm.csic.esTitulado Superior Grado de Doctor
Tong Ran4054724ran.tong(at)cbm.csic.esM3 Predoc.formación
Tur GraciaSara4054724/4702sara.tur(at)cbm.csic.esTitulado Sup. Actividades Tecn. y Prof.GP1


Relevant publications:

  • Jodkowska K, Pancaldi V, Almeida R, Rigau M, Graña O, Fernández-Justel JM, Rodríguez-Acebes S, Rubio-Camarillo M, Carrillo-de Santa Pau E, Pisano D, Al-Sharour F, Valencia A, *Gómez M and *Méndez J. 2019. Three-dimensional connectivity and chromatin environment mediate the stochastic activation of stress-responsive DNA replication origins. BioRxiv 644971 doi:10.1101/644971 *CO-CORRESPONDING AUTHORS
  • Almeida, R., Fernández-Justel, J. M., Santa-María, C., Cadoret, J. C., Cano-Aroca, L., Lombraña, R., Herranz, G., Agresti, A. and Gómez, M. 2018. Chromatin conformation regulates the coordination between DNA replication and transcription. Nat Commun, 9:1590. PUBLICACIÓN RECOMENDADA EN FACULTY OF 1000
  • Lombraña, R., Álvarez, A., Fernández-Justel, J. M., Almeida, R., Poza-Carrión, C., Gomes, F., Calzada, A., Requena, J. M. and Gómez, M. 2016. Transcriptionally driven DNA replication programme of the human parasite Leishmania major. Cell Rep, 16: 1-13.
  • Lombraña, R., Almeida, R., Revuelta, I., Madeira, S., Herranz, G., Saiz, N., Bastolla, U. and Gómez, M. 2013. High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins. EMBO J. 32: 2631-2644.

NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it. Learn more

I understand


What are cookies?

A cookie is a file that is downloaded to your computer when you access certain web pages. Cookies allow a web page, among other things, to store and retrieve information about the browsing habits of a user or their equipment and, depending on the information they contain and the way they use their equipment, they can be used to recognize the user.

Types of cookies

Classification of cookies is made according to a series of categories. However, it is necessary to take into account that the same cookie can be included in more than one category.

  1. Cookies according to the entity that manages them

    Depending on the entity that manages the computer or domain from which the cookies are sent and treat the data obtained, we can distinguish:

    • Own cookies: those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which the service requested by the user is provided.
    • Third party cookies: those that are sent to the user's terminal equipment from a computer or domain that is not managed by the publisher, but by another entity that processes the data obtained through the cookies. When cookies are installed from a computer or domain managed by the publisher itself, but the information collected through them is managed by a third party, they cannot be considered as own cookies.

  2. Cookies according to the period of time they remain activated

    Depending on the length of time that they remain activated in the terminal equipment, we can distinguish:

    • Session cookies: type of cookies designed to collect and store data while the user accesses a web page. They are usually used to store information that only is kept to provide the service requested by the user on a single occasion (e.g. a list of products purchased).
    • Persistent cookies: type of cookies in which the data is still stored in the terminal and can be accessed and processed during a period defined by the person responsible for the cookie, which can range from a few minutes to several years.

  3. Cookies according to their purpose

    Depending on the purpose for which the data obtained through cookies are processed, we can distinguish between:

    • Technical cookies: those that allow the user to navigate through a web page, platform or application and the use of different options or services that exist in it, such as controlling traffic and data communication, identifying the session, access to restricted access parts, remember the elements that make up an order, perform the purchase process of an order, make a registration or participation in an event, use security elements during navigation, store content for the broadcast videos or sound or share content through social networks.
    • Personalization cookies: those that allow the user to access the service with some predefined general characteristics based on a series of criteria in the user's terminal, such as the language, the type of browser through which the user accesses the service, the regional configuration from where you access the service, etc.
    • Analytical cookies: those that allow the person responsible for them to monitor and analyse the behaviour of the users of the websites to which they are linked. The information collected through this type of cookies is used in the measurement of the activity of the websites, applications or platforms, and for the elaboration of navigation profiles of the users of said sites, applications and platforms, in order to introduce improvements in the analysis of the data of use made by the users of the service.

Cookies used on our website

The CBMSO website uses Google Analytics. Google Analytics is a simple and easy to use tool that helps website owners to measure how users interact with the content of the site. You can consult more information about the cookies used by Google Analitycs in this link.

Acceptance of the Cookies Policy

The CBMSO assumes that you accept the use of cookies if you continue browsing, considering that it is a conscious and positive action from which the user's consent is inferred. In this regard, you are previously informed that such behaviour will be interpreted that you accept the installation and use of cookies.

Knowing this information, it is possible to carry out the following actions:

  • Accept cookies: if the user presses the acceptance button, this warning will not be displayed again when accessing any page of the portal.
  • Review the cookies policy: the user can access to this page in which the use of cookies is detailed, as well as links to modify the browser settings.

How to modify the configuration of cookies

Using your browser you can restrict, block or delete cookies from any web page. In each browser the process is different, here we show you links on this particular of the most used browsers: