CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA

Molecular mechanisms of sex-differences in metabolism physiology and disease

Research summary:

It is evident that women and men, female and male animals, are biologically different, resulting from genetic, epigenetic, hormonal, and environmental factors. However, the progress in the understanding of the sex-specific physio-pathology is still marginal. Therefore, it is not surprising that such a limited comprehension of the molecular mechanisms hampers the development of appropriate therapeutic strategies.
Our laboratory aims to understand the molecular mechanisms underlying metabolic sex-differences in health and disease, explicitly exploring mitochondria's role as the central hub where all metabolic functions converge.

We are currently addressing the role of mitochondria leading to a sex-specific response to heart failure and glucose metabolism. Our studies capitalize on in vivo and in vitro analysis combining biochemistry approaches to omics techniques.

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Figure 1.

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Last nameNameLaboratoryExt.*e-mailProfessional category
Cogliati Sara4274514 scogliati(at)cbm.csic.esInvestigador
Garcia-Consuegra MartinezJose4274514Estudiante TFM
González ColmenarejoLucía4274739Estudiante TFG

Relevant publications:

  • Digitonin concentration is determinant for mitochondrial supercomplexes analysis by BlueNative Page. Sara Cogliati*, Fernando Herranz, Jesús Ruiz-Cabello and José Antonio Enríquez* (*co-correspondent authors), BBA-Bioenergetics, 2012 Vol. 1862 pag.1-7.
  • Functional Role of Respiratory Supercomplexes in Mice: SCAF1 Relevance and Segmentation of the Q pool. Enrique Calvo*, Sara Cogliati*, Pablo Hernansanz-Agustín*, Marta Loureiro-López*, Adela Guarás, Rafael A Casuso, Fernando García-Marqués, Rebeca Acín-Pérez, Yolanda Martí-Mateos, J C Silla-Castro, Marta Carro-Alvarellos, Jesús R Huertas, Jesús Vázquez, J A Enríquez. (*equally contribution). Science Adv. 2020 Jun 24;6(26)
  • Scaf1 Promotes Respiratory Supercomplexes and Metabolic Efficiency in Zebrafish. Carolina García-Poyatos, Sara Cogliati, Enrique Calvo, Pablo Hernansanz-Agustín, Sylviane Lagarrigue, Ricardo Magni, Marius Botos, Xavier Langa, Francesca Amati, Jesús Vázquez, Nadia Mercader, José Antonio Enríquez. EMBO Rep. 2020 Jul 3;21(7):e50287.
  • Stay fit, stay young: mitochondria in movement. The role of exercise in the new mitochondrial paradigm. Jesus R. Huertas, Rafael Casuso, Pablo Hernansanz Agustín and Sara Cogliati*. (*corresponding author) Oxidative Medicine and Cellular Longevity, 2019, Vol.2019, pag.1-18.
  • Regulation of Mitochondrial Electron Transport Chain Assembly. Sara Cogliati, Isotta Lorenzi, Giovanni Rigoni, Federico Caicci and Maria Eugenia Soriano. Journal of Molecular Biology, 2018, Vol. 430(24), pag.4849-4873.
  • Mechanism of super-assembly of respiratory complexes III and IV. Sara Cogliati; Enrique Calvo; Marta Loureiro; Adela M. Guaras; Rocio Nieto-Arellano; Carolina Garcia-Poyatos; Iakes Ezkurdia; Nadia Mercader; Jesus Vazquez; Jose Antonio Enriquez. Nature 2016, Vol. 539 (7630), pag. 579-582
  • Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency. Sara Cogliati; Christian Frezza; Maria Eugenia Soriano; Tatiana Varanita; Ruben Quintana-Cabrera; Mauro Corrado; Sara Cipolat; Veronica Costa; Alberto Casarin; Ligia C. Gomes; Ester Perales-Clemente;Leonardo Salviati; Patricio Fernandez-Silva; Jose A. Enriquez; Luca Scorrano. Cell 2013, Vol.155 (1) pag.160-171

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