Molecular basis of Huntington's disease and other central nervous system disorders
Research summary:

Tau Nuclear Rods (TNRs) in neurons of an HD patient.

Expression of the transcription factor ATF5 in mouse hippocampal neurons.

Last name | Name | Laboratory | Ext.* | Professional category | |
---|---|---|---|---|---|
Elorza Peregrina | Ainara | 209 | 4582 | aelorza(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
Lozano Muñoz | David | 209 | 4552 | dlozano(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
Lucas Lozano | José Javier | 209 | 4552 | jjlucas(at)cbm.csic.es | E. Profesores de Investigación de Organismos Públicos de Investigación |
Lucas Santamaría | Miriam | 209 | 4582 | mmlucas(at)cbm.csic.es | Contratado CIBER |
Ollá | Ivana | 209 | 4582 | ivanaolla(at)cbm.csic.es | Contratado CIBER |
Picó del Pino | Sara | 209 | 4582 | sara.pico(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
Rodríguez López | Claudia | 209 | 4582 | crodriguez(at)cbm.csic.es | Titulado Sup. Actividades Tecn. y Prof.GP1 |
Santos Galindo | María | 209 | 4582 | msantos(at)cbm.csic.es | E. Técnicos Superiores Especializados de Organismos Públicos de Investigación |
Relevant publications:
- Elorza A, Marquez Y, Cabrera JR, Sanchez-Trincado JL, Santos-Galindo M, Hernandez IH, Diaz-Hernandez JI, Garcia-Escudero R, Irimia M and Lucas JJ (2021) Huntington’s disease-specific mis-splicing unveils key effector genes and altered splicing factors. Brain (in press) BioRxiv preprint: doi.org/10.1101/2020.05.11.086017
- Hernández IH, Cabrera JR, Santos-Galindo M, Sánchez-Martín M, Domínguez V, García-Escudero R, Pérez-Álvarez MJ, Pintado B and Lucas JJ (2020) Pathogenic SREK1 decrease in Huntington’s disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Brain 143:2207-19
- Parras A, de Diego-Garcia L, Alves M, Beamer E, Conte G, Jimenez-Mateos EM, Morgan J, Ollà I, Hernandez-Santana Y, Delanty N, Farrell MA, O’Brien DF, Ocampo A, Henshall DC, Méndez R, Lucas JJ* and Engel T* (2020) mRNA polyadenylation as a novel regulatory mechanism of gene expression in temporal lobe epilepsy. Brain 143:2139-53
- Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S, Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind DH, Méndez R, Lucas JJ. (2018) Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 560:441-6
- Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. (2017) The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease. Acta Neuropathol. 134:839-50
- McKinnon C, Goold R, Andre R, Devoy A, Ortega Z, Moonga J, Linehan JM, Brandner S, Lucas JJ, Collinge J and Tabrizi SJ. (2015) Prion-mediated neurodegeneration associated with early impairment ofubiquitin-proteasome system. Acta Neuropathol. 131:411-25
- Fernández-Nogales M, Cabrera JR, Santos-Galindo M, Hoozemans JJM, Ferrer I, Rozemuller AJM, Hernández F, Avila J and Lucas JJ (2014) Huntington’s disease is a four-repeat tauopathy with tau-nuclear rods. Nat Med 20, 881-5
- Torres-Peraza JF, Engel T, Martín-Ibañez R, Fernández-Fernández MR, Esgleas M, Canals JM, Henshall DC & Lucas JJ (2013) Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus. Brain 136:1161-76
- Gomez-Sintes R and Lucas JJ (2010) NFAT/Fas-signaling mediates apoptosis and neurological side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest 120:2432-45
- Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Diaz-Hernandez M, Brundin P, Overkleeft H, Li JY, Lucas JJ & Dantuma N (2009) Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment. PNAS 106:13986-91
- Gómez-Sintes R, Hernández F, Bortolozzi A, Artigas F, Avila J, Zaratin P, Gotteland J-P & Lucas JJ (2007) Neuronal apoptosis and reversible motor deficit in dominat-negative GSK-3 conditional transgenic mice. EMBO J. 26: 2743-54
- Lucas JJ, Hernández F, Gómez-Ramos P, Morán MA, Hen R, and Avila J (2001). Decreased nuclear ß-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3ß conditional transgenic mice. EMBO J. 20, 27-39
- Yamamoto A*, Lucas JJ* & Hen R (2000) *These authors contributed equally to the work. Reversal of neuropathology and motor dysfunction in a conditional model of Huntingtron´s Disease. Cell 101: 57-66
Other activities:
- Part of the Networking Research Center on Neurodegenerative Diseases (CIBERNED)
- José Lucas named Member of the National Royal Academy of Pharmacy in June 2011