Tau function and dysfunction in Alzheimer disease

Research summary:

During years a main objective in our group has been the characterization of the function of the cytoskeletal proteins known as microtubule associated proteins (MAPs). One of these MAPs, MAP1B, is a protein that is mainly located at the axon, in neurons. Now, we have found that MAP1B plays an important role in the development of dendritic spines. On the other hand, we are mainly focusing our studies on other MAP, tau protein. Tau protein appears to play a role in Alzheimer disease and other dementias (tauopathies). Tau protein is a suitable substract for GSK3, a protein kinase also known as tau kinase 1 and that is also related to some features of Alzheimer disease. We have several works about tau and GSK3 and we have isolated, some years ago, a transgenic mouse that overexpresses GSK3. Now, using this mouse, we have studied the neurogenesis at the dentate gyrus. Our results have indicated a decrease in that neurogenesis, in the transgenic mouse, that results in degeneration of dentate gyrus. This degeneration is due to cell death but also to the indicated impaired neurogenesis. These features may be the cause of the memory deficits found in the transgenic mouse. Our actual studies will analyze if the memory impairment found in Alzheimer disease patients are also based in a deficient neurogenesis taking place at the dentate gyrus of the patients.


Retrovirus labeled granule neurons in the dentate gyrus of Alzheimer disease mouse model.


Neuroblastoma cells overexpressing tau-GFP (green), stained with anti-EB1 (red). Although both proteins interact with microtubules, tau is a classical MAP that binds along the microtubule lattice, whereas EB1 is a +TIP that associates with microtubule "+" ends.


* For external calls please dial 34 91196 followed by the extension number
Last nameNameLaboratoryExt.*e-mailProfessional category
Anton FernándezAlejandro2084803aanton(at)cbm.csic.esDoctor FC3
Arriba EnríquezJosé de2084564Contratado CIBER
Ávila de GradoJesús2084564javila(at)cbm.csic.esDoctor Vinculado "Ad Honorem"
Bolos JuradoMarta2084803mbolos(at)cbm.csic.esContratado CIBER
Cuadros CatalánRaquel2084592rcuadros(at)cbm.csic.esE.Ayudantes De Invest. De Los Oo.Publicos De Investigacion
García-Escudero BarreraVega2084592vescudero(at)cbm.csic.esProfesor Titular Universidad, GA
García GarcíaEsther2084592esther.garcia(at)csic.esE.Ayudantes De Invest. De Los Oo.Publicos De Investigacion
Gómez RamosAlberto2084592agomez(at)cbm.csic.esContratado CIBER
Medina PadillaMiguel2084592Contratado CIBER
Pallas BazarraNoemí2084592npallas(at)cbm.csic.esContratado CIBER
Peinado CaucholaRocio2084564rpeinado(at)cbm.csic.esTitulado Sup. Actividades Tecn. y Prof.GP1
Perea Úbeda-PortuguésJuan Ramón2084592jrperea(at)cbm.csic.esEstancia/CIBER
Ruiz GabarreDaniel2084592daniel.ruiz(at)cbm.csic.esContratado CIBER
Torre AlonsoNuria de la2084803ndelatorre(at)cbm.csic.esTitulado Medio de Actividades Tecn.y Prof.GP2

Relevant publications:

  • Avila, J., Pallas, N., Bolos, M., Sayas, C. L. & Hernandez, F. (2016) Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies, Expert Opin Ther Targets. 20, 653-61.
  • Jurado-Arjona, J., Llorens-Martin, M., Avila, J. & Hernandez, F. (2016) GSK3beta Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills, J Biol Chem. 291, 8199-213.
  • Leon-Espinosa, G., Garcia, E., Gomez-Pinedo, U., Hernandez, F., DeFelipe, J. & Avila, J. (2016) Decreased adult neurogenesis in hibernating Syrian hamster, Neuroscience. 333, 181-192.
  • Llorens-Martin, M., Jurado-Arjona, J., Bolos, M., Pallas-Bazarra, N. & Avila, J. (2016) Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus, Brain Behav Immun. 53, 242-54.
  • Llorens-Martin, M., Teixeira, C. M., Jurado-Arjona, J., Rakwal, R., Shibato, J., Soya, H. & Avila, J. (2016) Retroviral induction of GSK-3beta expression blocks the stimulatory action of physical exercise on the maturation of newborn neurons, Cell Mol Life Sci. 73, 3569-82.
  • Martin-Maestro, P., Gargini, R., Perry, G., Avila, J. & Garcia-Escudero, V. (2016) PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease, Hum Mol Genet. 25, 792-806.
  • Medina, M., Hernandez, F. & Avila, J. (2016) New Features about Tau Function and Dysfunction, Biomolecules. 6, E21.
  • Bolos, M., Llorens-Martin, M., Perea, J. R., Jurado-Arjona, J., Rabano, A., Hernandez, F. & Avila, J. (2017) Absence of CX3CR1 impairs the internalization of Tau by microglia, Molecular neurodegeneration. 12, 59.
  • Garcia-Ayllon, M. S., Botella-Lopez, A., Cuchillo-Ibanez, I., Rabano, A., Andreasen, N., Blennow, K., Avila, J. & Saez-Valero, J. (2017) HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain, Mol Neurobiol. 54, 188-199.
  • Moreno, H., Morfini, G., Buitrago, L., Ujlaki, G., Choi, S., Yu, E., Moreira, J. E., Avila, J., Brady, S. T., Pant, H., Sugimori, M. & Llinas, R. R. (2016) Tau pathology-mediated presynaptic dysfunction, Neuroscience. 325, 30-8.

Doctoral theses:

  • Noemí Pallas Bazarra (2015).Estudio del papel de la proteína tau en la modulación de la neurogénesis hipocampal adulta. Universidad Autónoma de Madrid. Directores: María Llorens-Martín y Félix Hernández.
  • Patricia Martín-Maestro (2016). Mitophagy dysfunction in peripherasl and neural models of Alzheimer disease. Universidad Autónoma de Madrid. Directores: Vega García-Escudero y Jesús Avila.

NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it. Learn more

I understand


What are cookies?

A cookie is a file that is downloaded to your computer when you access certain web pages. Cookies allow a web page, among other things, to store and retrieve information about the browsing habits of a user or their equipment and, depending on the information they contain and the way they use their equipment, they can be used to recognize the user.

Types of cookies

Classification of cookies is made according to a series of categories. However, it is necessary to take into account that the same cookie can be included in more than one category.

  1. Cookies according to the entity that manages them

    Depending on the entity that manages the computer or domain from which the cookies are sent and treat the data obtained, we can distinguish:

    • Own cookies: those that are sent to the user's terminal equipment from a computer or domain managed by the editor itself and from which the service requested by the user is provided.
    • Third party cookies: those that are sent to the user's terminal equipment from a computer or domain that is not managed by the publisher, but by another entity that processes the data obtained through the cookies. When cookies are installed from a computer or domain managed by the publisher itself, but the information collected through them is managed by a third party, they cannot be considered as own cookies.

  2. Cookies according to the period of time they remain activated

    Depending on the length of time that they remain activated in the terminal equipment, we can distinguish:

    • Session cookies: type of cookies designed to collect and store data while the user accesses a web page. They are usually used to store information that only is kept to provide the service requested by the user on a single occasion (e.g. a list of products purchased).
    • Persistent cookies: type of cookies in which the data is still stored in the terminal and can be accessed and processed during a period defined by the person responsible for the cookie, which can range from a few minutes to several years.

  3. Cookies according to their purpose

    Depending on the purpose for which the data obtained through cookies are processed, we can distinguish between:

    • Technical cookies: those that allow the user to navigate through a web page, platform or application and the use of different options or services that exist in it, such as controlling traffic and data communication, identifying the session, access to restricted access parts, remember the elements that make up an order, perform the purchase process of an order, make a registration or participation in an event, use security elements during navigation, store content for the broadcast videos or sound or share content through social networks.
    • Personalization cookies: those that allow the user to access the service with some predefined general characteristics based on a series of criteria in the user's terminal, such as the language, the type of browser through which the user accesses the service, the regional configuration from where you access the service, etc.
    • Analytical cookies: those that allow the person responsible for them to monitor and analyse the behaviour of the users of the websites to which they are linked. The information collected through this type of cookies is used in the measurement of the activity of the websites, applications or platforms, and for the elaboration of navigation profiles of the users of said sites, applications and platforms, in order to introduce improvements in the analysis of the data of use made by the users of the service.

Cookies used on our website

The CBMSO website uses Google Analytics. Google Analytics is a simple and easy to use tool that helps website owners to measure how users interact with the content of the site. You can consult more information about the cookies used by Google Analitycs in this link.

Acceptance of the Cookies Policy

The CBMSO assumes that you accept the use of cookies if you continue browsing, considering that it is a conscious and positive action from which the user's consent is inferred. In this regard, you are previously informed that such behaviour will be interpreted that you accept the installation and use of cookies.

Knowing this information, it is possible to carry out the following actions:

  • Accept cookies: if the user presses the acceptance button, this warning will not be displayed again when accessing any page of the portal.
  • Review the cookies policy: the user can access to this page in which the use of cookies is detailed, as well as links to modify the browser settings.

How to modify the configuration of cookies

Using your browser you can restrict, block or delete cookies from any web page. In each browser the process is different, here we show you links on this particular of the most used browsers: