Ofertas de Empleo
Predoctoral Position – Fundación La Caixa – INCOMING FELLOWSHIP
The autophagic machinery as a possible target for cancer immunotherapy
Our laboratory has been selected to host a PhD candidate from La Caixa Foundation (Incoming Program) to examine the role of the autophagic machinery in the control of the immunogenic potential of programmed cell death, with the ultimate intention of evaluating its potential as a therapeutic target in cancer
Interested candidates please contact: fxp@cbm.csic.es
Predoctoral Position – Fundación La Caixa – RETAINING FELLOWSHIP
Unconventional autophagic mechanisms and their role in health and disease
The project intends to identify novel unconventional activities carried out by the molecular machinery that regulates mammalian autophagy and establish their role in the prevention of human diseases, with a focus on inflammatory pathologies and cancer
Interested candidates please contact: fxp@cbm.csic.es
Postdoctoral Researcher
Pathophysiology of the Organ Fibrosis
Fibrosis is defined by scarring and tissue hardening caused by excess deposition of extracellular matrix (ECM) components, mainly collagens. A fibrotic response can occur in any tissue of the body and is the final outcome of an unbalanced reaction to inflammation and wound healing induced by a variety of insults, including persistent infections, autoimmune reactions, allergic responses, chemical exposure, radiation, and tissue injury. Intensive research in recent years has identified several pathways involved in the activation and persistence of fibroblasts typically found in fibrotic tissues. However, the treatment options are scarce and ineffective, therefore, there is an urgent need for new pharmacological therapies. Our current research investigates the crosstalk between ECM deposition and stiffness and the cellular responses to hypoxia and metabolic reprogramming in the development of fibrosis.
Fernando Rodríguez Pascual (frodriguez@cbm.csic.es)
Research technician/lab manager
Inhibiting a novel interaction to sensitize breast cancer cells to radiotherapy
The Carreira lab interrogates the mechanisms of the cell to preserve genome integrity using human BRCA2 protein as a model and the consequences of its mutation in breast cancer predisposition. In this project we will leverage the use of a newly identified partner of BRCA2 as a target to sensitize breast cancer cells to radio or chemotherapy. More information about our team at: Carreira-Lab
31st/10/2023
Interested applicants should submit their CV including contact details from 2-3 references to acarreira@cbm.csic.es
Date of publication: 11/10/2023
Predoctoral researcher (application for a predoctoral fellowship from the Fundación Ramón Areces)
Cardioprotective role of the Keap1/Nrf2/ARE pathway in ischemia-reperfusion injury
The antioxidant transcription factor Nrf2 promotes cell survival under oxidative stress conditions. Nrf2 binds to antioxidant response elements (ARE) in the promoters of its target genes, inducing the expression of antioxidant proteins.The aim of this study is to determine the role of Nrf2 in the protection of the heart against ischemia-reperfusion injury and its potential therapeutic value.
11/10/2023
Please send your applications together with an updated CV, a motivation letter and academic record. Lab webpage: https://www.cbm.csic.es/scadenas
Date of publication: 05/10/2023
Predoctoral Investigator (application for a predoctoral fellowship-Fundación Ramón Areces)
Mechanisms of Tumorigenesis in Drosophila
The main focus of our research is the study of tumorigenesis, a phenomenon of great scientific and societal relevance. Because of its sophisticated genetic technology and other experimental advantages, we are using the imaginal discs of the fruitfly Drosophila melanogaster as a model system to investigate molecular and genetic factors behind the appearance and development of tumors. We are focusing on the formation of cells with DNA lesions that cannot execute the apoptotic program and become senescent.
11/10/2023
If interested please send an email with the academic record.
Date of publication: 04/10/2023
Postdoctoral Researcher CBMSO Call
Structure, function and regulation of GlyT2 variants associated to hyperekplexia.
Hyperekplexia (OMIM 149400) is a rare sensorimotor syndrome potentially lethal in newborns. It is caused by defects in the inhibitory glycinergic neurotransmission due to mutations in some human genes such as the neuronal glycine transporter GlyT2 (SLC6A5), responsible for supplying glycine to the presynaptic terminal. In this project, the pathogenic mechanisms of GlyT2 mutations found in hyperekplexia patients will be analyzed in terms of the structure of the transporter, its function, intracellular trafficking, interactome, regulation, as well as its consequences in embryonic or adult life. This study can guide future therapeutic approaches we wish to develop. http://www.cbm.uam.es/blopez
12/01/2023
Date of publication: 04/10/2023
Lab technician
Mitochondrial dysfunction in metabolic diseases
Mitochondria are unique and complex organelles that perform essential functions in many aspects of cell biology. Once considered to be mere sites of ATP generation, it is now evident that these organelles participate in a wide range of cellular processes including calcium homeostasis, apoptosis, redox balance or cell fate. Because of this multifaceted contribution of mitochondria to key biologic and metabolic pathways it is not surprising that mitochondrial dysfunction has been linked to many human disorders including neurodegeneration, diabetes, cancer or aging. The Balsa laboratory seeks to understand the basic molecular components that regulate mitochondrial function and integrate this knowledge in the context of human physiology and disease. Specifically in this project, we aim to elucidate the molecular mechanisms whereby mitochondrial dysfunction compromise cellular fitness and leads to organ failure in the context of human diseases.
Interested applicants should submit their CV, to ebalsa@cbm.csic.es.
30/11/2023
Lab technician
Shaping specialized replisomes to shape cell identity
DNA replication mediates the faithful copy of genetic information of the cell. In this project we want to analyze how the replication machinery is adapted to different chromatin environments and cellular identities, co-ordinating DNA replication dynamics with the transcriptional program in the cells. We are also interested in determining how DNA replication dynamics are modified during cellular transformation to enable the proliferation of cancer cells. In this project we will use different models of cells in culture, combining cell biology and biochemistry approaches to understand how the replication machinery changes DNA replication dynamics to influence cell identity. We are looking for a technician to work part-time to support the general work in the lab and the development of this project.
or related. Research experience in cell and molecular biology, and in mammalian cell culture
will be positively valued. Good knowledge of English is also positively valued.
31/10/2023
Please send your applications together with an updated CV, motivation letter and academic
record.
Lab web page https://www.cbm.uam.es/elecona
Predoctoral lnvestigator (application for a predoctoral fellowship- Fundación Ramón Areces)
Unconventional autophagy in health and disease
Our lab studies the role of unconventional autophagic mechanisms in physiological processes linked to diseases like inflammatory pathologies, antitumor immunity and innate defense against bacteria! infections. More information in the lab web page: https://www.cbm.uam.es/fxpimentel
10/10/2023
lnterested candidates please send CV, academic track record, motivation letter and contact information of possible references to the Principal lnvestigator: fxp@cbm.csic.es
Investigador predoctoral (convocatoria FPI de la UAM)/Predoctoral Researcher (UAM FPI call)
Structure, function and regulation of GlyT2 variants associated to hyperekplexia.
Hyperekplexia (OMIM 149400) is a rare sensorimotor syndrome potentially lethal in newborns. It is caused by defects in the inhibitory glycinergic neurotransmission due to mutations in some human genes such as the neuronal glycine transporter GlyT2 (SLC6A5), responsible for supplying glycine to the presynaptic terminal. In this project, the pathogenic mechanisms of GlyT2 mutations found in hyperekplexia patients will be analyzed in terms of the structure of the transporter, its function, intracellular trafficking, interactome, regulation, as well as its consequences in embryonic or adult life. This study can guide future therapeutic approaches we wish to develop.
19/09/2023
Se ofrece formación multidisciplinar en ambiente dinámico y colaborativo utilizando sistemas de expresión de mutantes en células y cultivos primarios de neuronas para ensayos funcionales de transporte, tráfico intracelular, actividad eléctrica, así como estudios in vivo en pez cebra. Los candidatos deben enviar CV, expediente académico y carta de motivación a la Dra. Beatriz López Corcuera (blopez@cbm.csic.es). / We offer multidisciplinary training in a dynamic and collaborative environment using mutant expression systems in cells and primary neuronal cultures for functional assays of transport, intracellular trafficking, electrical activity, as well as in vivo studies in zebrafish. Candidates must send CV, academic record and motivation letter to Dr. Beatriz López Corcuera (blopez@cbm.csic.es).
FPI, 4 years PhD
Fao impairment in system homeostasis
A four-year Ph.D. contract is offered by the Mitochondria in Pathology group, led by Professor Laura Formentini at the Universidad Autonoma de Madrid (UAM), Centro de Biología Molecular Severo Ochoa (CBMSO), attached to a recently awarded grant funded by the Agencia Estatal de Investigación (contrato FPI). The student will participate in a project aimed at investigating the impact of restrained mitochondrial activity in the development of metabolic disorders and aging.
20/09/2023
Investigador predoctoral (convocatoria FPI de la UAM)/Predoctoral Researcher (UAM FPI call)
Structure, function and regulation of GlyT2 variants associated to hyperekplexia.
Hyperekplexia (OMIM 149400) is a rare sensorimotor syndrome potentially lethal in newborns. It is caused by defects in the inhibitory glycinergic neurotransmission due to mutations in some human genes such as the neuronal glycine transporter GlyT2 (SLC6A5), responsible for supplying glycine to the presynaptic terminal. In this project, the pathogenic mechanisms of GlyT2 mutations found in hyperekplexia patients will be analyzed in terms of the structure of the transporter, its function, intracellular trafficking, interactome, regulation, as well as its consequences in embryonic or adult life. This study can guide future therapeutic approaches we wish to develop.
/Degree in Medicine, Biology, Biochemistry, Biotechnology, Pharmacy or similar. Master completed in the area of Biomedicine. Highly motivated candidates with a good academic record (≥ 8,5) for the completion of the doctorate.
Se ofrece formación multidisciplinar en ambiente dinámico y colaborativo utilizando sistemas de expresión de mutantes en células y cultivos primarios de neuronas para ensayos funcionales de transporte, tráfico intracelular, actividad eléctrica, así como estudios in vivo en pez cebra. Los candidatos deben enviar CV, expediente académico y carta de motivación a la Dra. Beatriz López Corcuera (blopez@cbm.csic.es). / We offer multidisciplinary training in a dynamic and collaborative environment using mutant expression systems in cells and primary neuronal cultures for functional assays of transport, intracellular trafficking, electrical activity, as well as in vivo studies in zebrafish. Candidates must send CV, academic record and motivation letter to Dr. Beatriz López Corcuera
(blopez@cbm.csic.es).
PhD position / Marie-Curie DN Contract (2x)
The role of neonatal enterocytes in gut patterning and development, and their impact on inflammation, and cancer (SurfEx)
Our lab is seeking highly motivated candidates to develop their PhD in the field of Cell Biology and Biomedicine supported by a Marie Curie DN contract (SurfEx-101119504). We are very interested in characterizing the crosstalk between the enterocytes and immune cells during development and pathologies, with particular emphasis In the role that metabolism play during this process. To address these questions, we use in vitro and in vivo techniques, including cutting-edge high-resolution microscopy, engineered organoids, quantitative genomics and proteomics and murine models.
Candidates must not have resided, or carried out main activity, in Spain for more than 12 months in the 36 months immediately before their recruitment date.
Four‐year predoctoral contract OPTI‐CAR‐T
The “Development of the human lymphohematopoietic system” group, led by Marisa Toribio at the Centro de Biología Molecular Severo Ochoa (CBMSO), is looking for a highly motivated candidate to develop her/his thesis in their lab. They offer incorporation via a 4‐year predoctoral contract (FPI programme) linked to the project “Overcoming current challenges of CAR‐T cell immunotherapy for T‐ALL leukemia with optimized CAR constructs (TRuCs) and universal, off‐the‐shelf, effector allogeneic T cells (OPTI‐CAR‐T)” (PID2022‐138880OB‐I00) funded by the Spanish Ministry of Science and Innovation (MICIN) and the State Research Agency (AEI).
• Graduate in biomedical sciences or related areas, with a minimum of 300 ECTS through official university studies, with a minimum of 60 ECTS in master studies.
• Academic record with an average grade over 8 (out of 10).
• Experience in in vivo mouse models, cell culture, immunology and molecular biology will be valued.
• Solid communication skills in English.
Further information:
About the group: http://www.cbm.uam.es/toribiolab
About the CBMSO: http://www.cbm.uam.es
If interested, please send an e‐mail including CV, academic record and 1‐2 reference letters from previous supervisors, no later than September 20th 2023, to:
Marisa Toribio mtoribio@cbm.csic.es
Investigador Predoctoral (convocatoria FPI de la UAM)/ predoctoral Researcher (UAM FPI call)
Alteraciones del ciclo celular y patrones de división de las células tumorales de mama en condiciones de estrés / Cell cycle alterations and division patterns
of breast tumor cells under stress conditions
Principal Investigators: Petronila Penela
Date of publication: 19/07/2023
Deadline: 20/09/2023
Opportunity details
Titulado Superior
Peptide Vaccines, Antiviral Strategies And Viral Immune Evasion Mechanisms. Biotherapeutic Applications
Principal Investigators: Francisco Sobrino and Margarita Sáiz
fsobrino@cbm.csic msaiz@cbm.csisc.es
Date of publication: 08/06/2023
Deadline: 30/06/2023
Opportunity details
Solicitud de contrato INVESTIGADOR PREDOCTORAL
Redes de señalización de receptores acoplados a proteínas G: nuevas vías de
señalización e implicaciones fisopatológicas de los interactomas de Gq y GRK2.
Las líneas de investigación estarán orientadas al estudio de redes de señ alizació n de GPCR, GRK2 y Gq en la homeostasis y comunicació n celular y de sus alteraciones en patologías inflamatorias, cardiovasculares y tumorales https://www.cbm.uam.es/cribas http://www.cbm.uam.es/fmayor
- Convocatoria de ayudas del Subprograma Ramón y Cajal 2021.
En el BOE del 29 de diciembre se publicó el extracto de la Resolución de la Presidencia de la Agencia Estatal de Investigación, por la que se aprueba la convocatoria de ayudas del Subprograma Ramón y Cajal 2021.
La Agencia Estatal de Investigación (AEI) ha realizado una reforma de las convocatorias posdoctorales Ramón y Cajal y Juan de la Cierva. Desaparece la figura de “Juan de la Cierva Incorporación” para hacer la carrera más corta, quedando incluida dicha figura dentro del Contrato Ramón y Cajal. Por ello, de las 647 ayudas convocadas, se han reservado 278 para jóvenes investigadores (grado de doctor obtenido después de 01/01/2017), además de 12 para personal investigador con discapacidad igual o superior al 33% y 10 para el turno RYC-INIA-CCAA.
La finalidad de estas ayudas es promover la incorporación de personal investigador, español y extranjero, con una trayectoria destacada en centros de I+D españoles, con el fin de que adquieran las competencias y capacidades que les permitan obtener un puesto de carácter estable en un organismo de investigación del Sistema Español de Ciencia, Tecnología e Innovación. La duración de las ayudas es de 5 años y este año como novedad la han dividido en dos fases: una primera fase cuyo objetivo es afianzar las capacidades adquiridas durante una primera etapa previa de formación posdoctoral, y una segunda fase a la que se podrá acceder a partir del 4º año una vez hayan obtenido la evaluación positiva de la actividad científico-técnica con criterio para ser investigador R3, dirigida a adquirir las competencias y capacidades que permitan obtener un puesto de carácter estable.
En el siguiente enlace Ayudas para contratos Ramón y Cajal 2021 pueden encontrar la resolución completa de la convocatoria, así como las preguntas frecuentes y modelos de documentos que los investigadores deben presentar en la solicitud.
